LEADER 03477nam 2200589Ia 450 001 9910830684303321 005 20170815152910.0 010 $a1-280-83870-1 010 $a9786610838707 010 $a0-470-05959-1 010 $a0-470-05958-3 035 $a(CKB)1000000000357108 035 $a(EBL)291030 035 $a(SSID)ssj0000244272 035 $a(PQKBManifestationID)11210408 035 $a(PQKBTitleCode)TC0000244272 035 $a(PQKBWorkID)10164999 035 $a(PQKB)10772566 035 $a(MiAaPQ)EBC291030 035 $a(PPN)243331355 035 $a(OCoLC)86240715 035 $a(EXLCZ)991000000000357108 100 $a20070202d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSepsis$b[electronic resource] $enew insights, new therapies 210 $aChichester, UK ;$aHoboken, NJ $cWiley$d2007 215 $a1 online resource (303 p.) 225 1 $aNovartis Foundation symposium ;$v280 300 $a"Symposium on Sepsis: new insights, new therapies, held at the Novartis Foundation, London, 14-16 February, 2006."--Contents. 311 $a0-470-02798-3 320 $aIncludes bibliographical references and indexes. 327 $aSepsis: New Insights, New Therapies; Contents; Chair's introduction; DISCUSSION; Strategies to modulate cellular energetic metabolism during sepsis; DISCUSSION; Immunostimulation is a rational therapeutic strategy in sepsis; DISCUSSION; Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis; DISCUSSION; Modulating neutrophil apoptosis; DISCUSSION; HMGB1 as a potential therapeutic target; DISCUSSION; Poly (ADP-ribose) polymerase activation and circulatory shock; DISCUSSION; Choosing the right substrate; DISCUSSION; Inhibiting glycogen synthase kinase 3b in sepsis 327 $aDISCUSSIONEthyl pyruvate: a novel treatment for sepsis; DISCUSSION; GENERAL DISCUSSION I; Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models; DISCUSSION; The hypothalamic pituitary adrenal axis in sepsis; DISCUSSION; Modulating the endocrine response in sepsis: insulin and blood glucose control; DISCUSSION; The neuronal strategy for inflammation; DISCUSSION; Beta-blockade in burns; DISCUSSION; System interactions; DISCUSSION; Protecting the permeability pore and mitochondrial biogenesis; DISCUSSION; Contributor index; Subject index 330 $aSepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. Addresses the frequent, b 410 0$aNovartis Foundation symposium ;$v280. 606 $aSepticemia$vCongresses 606 $aBlood$xDiseases$vCongresses 615 0$aSepticemia 615 0$aBlood$xDiseases 676 $a616.944 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830684303321 996 $aSepsis$91757179 997 $aUNINA