LEADER 05210nam 2200625Ia 450 001 9910830678003321 005 20170810193222.0 010 $a1-282-30663-4 010 $a9786612306631 010 $a3-527-62917-3 010 $a3-527-62918-1 035 $a(CKB)1000000000800002 035 $a(EBL)481630 035 $a(OCoLC)463436674 035 $a(SSID)ssj0000300232 035 $a(PQKBManifestationID)11205934 035 $a(PQKBTitleCode)TC0000300232 035 $a(PQKBWorkID)10251790 035 $a(PQKB)11574585 035 $a(MiAaPQ)EBC481630 035 $a(PPN)194586294 035 $a(EXLCZ)991000000000800002 100 $a20081120d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIntracellular niches of microbes$b[electronic resource] $ea pathogens guide through the host cell /$fedited by Ulrich E. Schaible & Albert Haas 210 $aWeinheim $cWiley-VCH$d2009 215 $a1 online resource (738 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32207-8 320 $aIncludes bibliographical references and index. 327 $aIntracellular Niches of Microbes: A Pathogens Guide Through the Host Cell; Foreword; Contents; List of Contributors; Part I: General Aspects; 1 Introduction: The Evolution of Intracellular Life Forms and their Niches; 1.1 A Short History of Theories and Discoveries; 1.2 A Look Through the Microscope of Evolution; 1.3 Continuous Exchange of Information; 1.4 Evolution of Intracellular Parasitism; 1.5 Intracellular Symbionts: Tamed or Acclimatized Parasites?; 1.6 An Ecological View of Intracellular Life; 1.7 The Immunologist's View; 1.8 The Public Health View; 1.9 The Book; References 327 $a2 Limited Genomes and Gene Transfer in the Evolution of Intracellular Parasitism and Symbiosis2.1 Introduction to Gene Transfer and Evolution; 2.2 Gene Transfer in Intracellular Bacterial Parasites; 2.3 Gene Transfer in Intracellular Symbionts; 2.4 Gene Transfer in Intracellular Parasites and Fungi; 2.5 Summary and Outlook; References; 3 Phagocytosis: Early Events in Particle Recognition and Uptake; 3.1 Phagocytosis: An Overview; 3.2 Recognition of Target Particles; 3.3 Signaling Events Upon Ligand Recognition; 3.4 Membrane Dynamics During Phagocytosis; 3.5 Phagosome Maturation 327 $a3.6 Inflammatory Signals Linked to Phagocytosis3.7 Concluding Remarks; References; 4 Cellular Model Systems Used to Study Phagosome Biogenesis; 4.1 From Grazing to Host Defense; 4.2 Dictyostelium, a Professional Phagocyte at the Border of Multicellularity; 4.3 Dictyostelium, a Surrogate Host for Legionella, Mycobacterium and Other Pathogens; 4.4 Legionella-directed Phagosome Biogenesis; 4.5 The Whole Animal Model Drosophila melanogaster; 4.6 Infection of Drosophila Phagocytes; 4.7 Conclusions; References; 5 Methods Used to Study Phagosome Biogenesis 327 $a5.1 Describing the World Within - Whole-Cell Assays for Phagosome Contents5.2 Biochemical Analysis and Assays with Purified Phagosomes; 5.3 Use of Fluorescence-Activated Cell Sorting (FACS) in Phagosome Research; 5.4 Knockdown, Knockout and Phagosome Research; 5.5 Transcriptomics as a Phagosome Environmental Sensor; References; 6 In Vitro Fusion Assays with Phagosomes; 6.1 Introduction; 6.2 A Variety of Assays; 6.3 Studying Normal Maturation . . .; 6.4 . . . and the Pathogenic Case; References 327 $a7 Phagosome Proteomes Unite! A Virtual Model of Maturation as a Tool to Study Pathogen-Induced Changes7.1 Background; 7.2 A Methods Guide to Phagosome Proteomics; 7.3 Particle-Induced Impact on Phagosome Isolation; 7.4 Comparative Proteomics of Microbe-Containing Vacuoles; 7.5 Conclusions; References; 8 Phagosome-Cytoskeleton Interactions; 8.1 Introduction; 8.2 The Actin Cytoskeleton. General Background; 8.3 The Microtubule Cytoskeleton - General Background; 8.4 Concluding Remarks; References 327 $a9 Intracellular Microbe Whole-Genome Expression Profiling: Methodological Considerations and Biological Inferences 330 $aThe book describes the different and exciting pathways which have been developed by pathogenic microbes to manage living inside host cells. It covers intracellular life styles of all relevant pathogenic but also symbiotic microorganisms with respect to the cell biology of the host-microbe interactions and the microbial adaptations for intracellular survival. It features intracellular trafficking pathways and characteristics of intracellular niches of individual microbes. The book also asks questions on the benefits for the microbe with regard to physiological needs and nutritional aspects such 606 $aHost-parasite relationships 606 $aIntracellular pathogens 615 0$aHost-parasite relationships. 615 0$aIntracellular pathogens. 676 $a577.857 701 $aSchaible$b Ulrich E$01663220 701 $aHaas$b Albert$cProf.$01663221 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830678003321 996 $aIntracellular niches of microbes$94020367 997 $aUNINA