LEADER 05108nam 22006134a 450 001 9910830663803321 005 20230721030036.0 010 $a1-280-91680-X 010 $a9786610916801 010 $a0-470-12938-7 010 $a0-470-12937-9 035 $a(CKB)1000000000356627 035 $a(EBL)302254 035 $a(OCoLC)476081301 035 $a(SSID)ssj0000204941 035 $a(PQKBManifestationID)11187247 035 $a(PQKBTitleCode)TC0000204941 035 $a(PQKBWorkID)10189440 035 $a(PQKB)10128599 035 $a(MiAaPQ)EBC302254 035 $a(EXLCZ)991000000000356627 100 $a20061103d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular nutrition and genomics$b[electronic resource] $enutrition and the ascent of humankind /$fMark Lucock 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2007 215 $a1 online resource (154 p.) 300 $aDescription based upon print version of record. 311 $a0-470-08159-7 320 $aIncludes bibliographical references (p. 123-132) and index. 327 $aMolecular Nutrition and Genomics; Contents; PREFACE; ACKNOWLEDGMENTS; INTRODUCTION; Chapter 1-Defining Important Concepts; 1.1 Key Concepts in Molecular Biology for the Study of Human Nutrition; 1.2 The Inheritance of Genetic Packets of Information; 1.3 A Brief Overview of Evolutionary Biology and the Ascent of Man; 1.4 The -omics Revolution; Chapter 2-Molecular Mechanisms of Genetic Variation Linked to Diet; 2.1 A Brief History of the Human Diet; 2.2 The Role of Milk in Human Evolution; 2.3 Micronutrients and the Evolution of Skin Pigmentation 327 $a2.4 Micronutrients Optimize Gametogenesis and Reproductive Fecundity2.5 Direct Dietary Selection of a Human Metabolomic Profile; 2.6 The Evolution of Taste as a Survival Mechanism; 2.7 The Mystery of Alcohol Dehydrogenase Polymorphisms and Ethanol Toxicity; 2.8 Evolution of Xenobiotic Metabolism in Humans; Chapter 3-Essential Nutrients and Genomic Integrity: Developmental and Degenerative Correlates; 3.1 Micronutrients and Genomic Stability and Function; Chapter 4-Nutrients and Cerebral Function in Human Evolution 327 $a4.1 Human Encephalisation May be Linked to an Evolutionary Reduction in Gut Mass4.2 Weaning and Brain Development; 4.3 Micronutrients and the Cerebral Basis of Spirituality and Social Structure; 4.4 Pharmacotoxicology of Plants and Cultural Evolution; Chapter 5-The Evolution of Micronutrient Metabolism; 5.1 Antioxidants, Evolution, and Human Health; Chapter 6-Evolved Refinement of the Human Lifecycle Based on Nutritional Criteria; 6.1 Human Breast Milk-An Evolved Food; 6.2 Conflict between Parent and Offspring over Nutrient Requirements; 6.3 Natural Selection for Foraging Efficiency 327 $a6.4 Evolution of SenescenceChapter 7-The Evolution of Human Disease; 7.1 The Conflict between Agriculture and Ancestral Genes; 7.2 Obesity: A Chronic Plague of our Affluent Societies; 7.3 Prion Protein Locus and Human Evolution: The Link Between Variant Creutzfeld-Jakob Disease and Cannibalism; Chapter 8-Contemporary Dietary Patterns that Work: The Mediterranean Diet; 8.1 Tomatoes; 8.2 Olive Oil; 8.3 Red Wine; 8.4 Bioflavonoids; 8.5 Fish; Chapter 9-Some Non-Micronutrient Essential and Nonessential Nutrients with Molecular and Possible Evolutionary Impact; 9.1 Lecithins 327 $a9.2 Lipid-Derived First Messengers-The Eicosanoids9.3 Isoflavones-Genomic and Nongenomic Influence at the Estrogen Receptor; 9.4 Phytic Acid; Chapter 10-Natural Food Toxins and the Human Diet; 10.1 Dietary Zootoxins; 10.2 Dietary Phytotoxins; Chapter 11-Nutrigenomics; 11.1 What is Nutrigenomics?; 11.2 Genetic Buffering Underpins Nutrigenomic Relationships; Chapter 12-The Evolution of Protein Function; Chapter 13-Leading Edge Laboratory Tools in Nutrigenomics and Human Evolutionary Studies; 13.1 Denaturing HPLC; 13.2 DNA Sequencing; 13.3 Nucleic Acid Microchip Techniques 327 $a13.4 The Polymerase Chain Reaction 330 $aThis fascinating book draws it subject matter from a range of relevant disciplines that extend from molecular nutrition, nutritional sciences, and nutrition dietetics through to genetics, genomics, and anthropology. It presents a vital portrait of the absolutely fundamental role that nutrition has played and continues to play in shaping who and what human beings are, as well as where they evolved from, and where they may be heading as a species. Molecular Nutrition: Nutrition and the Evolution of Humankind:Blends coverage of the molecular mechanisms that underpin nutrie 606 $aNutrition$xGenetic aspects 606 $aHuman evolution 615 0$aNutrition$xGenetic aspects. 615 0$aHuman evolution. 676 $a599.938 676 $a612.3 700 $aLucock$b Mark$01639444 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830663803321 996 $aMolecular nutrition and genomics$93982437 997 $aUNINA