LEADER 04294nam 2200613Ia 450 001 9910830647503321 005 20230607221537.0 010 $a1-281-31179-0 010 $a9786611311797 010 $a3-527-62102-4 010 $a3-527-62103-2 035 $a(CKB)1000000000408267 035 $a(EBL)481897 035 $a(OCoLC)609855478 035 $a(SSID)ssj0000290038 035 $a(PQKBManifestationID)11255023 035 $a(PQKBTitleCode)TC0000290038 035 $a(PQKBWorkID)10403753 035 $a(PQKB)11490638 035 $a(MiAaPQ)EBC481897 035 $a(EXLCZ)991000000000408267 100 $a20030613d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiological monitoring$b[electronic resource] $eprospects in occupational and environmental medicine : round table discussions and colloquia /$fedited by Ju?rgen Angerer (Discussion leader) and Tobias Weiss (editing) 210 $aBonn, Germany $cDeutsche Forschungsgemeinschaft ;$aWeinheim, Germany $cWiley-VCH$dc2002 215 $a1 online resource (213 p.) 300 $aDescription based upon print version of record. 311 $a3-527-27795-1 320 $aIncludes bibliographical references. 327 $aBiological Monitoring Prospects in Occupational and Environmental Medicine; Contents; Foreword; 1 The Importance of Biological Monitoring; 1.1 The Development and Importance of Biological Monitoring in the DFG and MAK Commission; 2 Internal Exposure and Haemoglobin Adducts; 2.1 Biological Monitoring in Occupational and Environmental Medicine - The Present State of the Art and Future Prospects; 2.2 Metabolic Profiling - A Way of Better Understanding External and Internal Exposure to Organic Stubstances; 2.3 Biological Monitoring of Arylamines and Nitroarenes; 3 DNA Adducts 327 $a3.1 Genetic Cancer Susceptibility and DNA Adducts: Studies in Smokers and Coke Oven Workers3.2 The Detection of DNA Adducts in Biological Monitoring; 3.3 (32)P-Postlabelling HPLC Analysis of DNA Adducts in Breast Tissue; 3.4 Studies of 8-Hydroxy-2 ?-Deoxyguanosine: A Biomarker for Oxidative DNA Damage in vivo?; 4 Susceptibility; 4.1 Improved Methods of Phenotyping and Effect Monitoring for Evaluating the Risk to the Individual, using GSTT1 as an Example; 4.2 Genetic Polymorphisms of Sulfotransferases as Susceptibility Parameters; 4.3 Genotyping and Phenotyping, Using NAT2 as an Example 327 $a4.4 New High-thoughput Technology in the Diagnostic Screening of Susceptibility Factors5 Cytogenetic Parameters; 5.1 Biological Monitoring with Cytogenetic Methods; 5.2 Examples of the Use of Three-colour Chromosome Painting in Cytogenetic Biomonitoring; 5.3 The Comet Assay as a Biological Monitoring Test; 6 Immunology; 6.1 Immunoglobulins as Markers of Long-term Exposure to Allergenic Substances; 6.2 Immunological Effects of Polymorphic Key Enzymes; 7 Epidemiology; 7.1 Evaluation of Exposure in Epidemiological Studies 327 $a7.2 Possibilities and Limitations of the Molecular Epidemiology of Workplace Exposures8 Summary; 9 Authors and Participants 330 $aAt the invitation of the Deutsche Forschungsgemeinschaft (DFG), a round-table discussion was held on 9 and 10 March 2000, dealing with future possibilities for biomonitoring in occupational and environmental medicine. Biomonitoring has reached a high standard in Germany over the past 30 years, not least due to the fact that the results of the Senate commission on materials hazardous to health at the workplace have been directly implemented as part of the jurisdiction relating to occupational safety.This book combines the expertise gathered from various areas within toxicology, occupati 606 $aBiological monitoring$vCongresses 606 $aIndustrial toxicology$vCongresses 615 0$aBiological monitoring 615 0$aIndustrial toxicology 676 $a613.62 676 $a615.902 701 $aAngerer$b J$098859 701 $aWeiss$b Tobias$01721417 712 02$aDeutsche Forschungsgemeinschaft. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830647503321 996 $aBiological Monitoring$94121022 997 $aUNINA