LEADER 02472oam 2200625I 450 001 9910791921003321 005 20230124184349.0 010 $a1-136-68236-8 010 $a1-283-54790-2 010 $a9786613860354 010 $a1-136-68237-6 010 $a0-203-81048-1 024 7 $a10.4324/9780203810484 035 $a(CKB)2560000000089343 035 $a(EBL)995717 035 $a(OCoLC)829462030 035 $a(SSID)ssj0000747446 035 $a(OCoLC)808367362 035 $a(MiAaPQ)EBC995717 035 $a(Au-PeEL)EBL995717 035 $a(CaPaEBR)ebr10592881 035 $a(CaONFJC)MIL386035 035 $a(OCoLC)695856994 035 $a(FINmELB)ELB139614 035 $a(EXLCZ)992560000000089343 100 $a20180706d2011 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe modern state /$fChristopher Pierson 205 $a3rd ed. 210 1$aLondon ;$aNew York :$cRoutledge,$d2011. 215 $a1 online resource (225 p.) 300 $aDescription based upon print version of record. 311 $a0-415-58762-X 311 $a0-415-58761-1 320 $aIncludes bibliographical references and index. 327 $aFront Cover; The Modern State; Copyright Page; Contents; Acknowledgements; Introduction; 1 Modern states; 2 Placing the state in modernity; 3 States and societies; 4 State and economy; 5 States and citizens; 6 States and the international order; 7 States of the twenty-first century; 8 Conclusion; Bibliography; Index 330 $aThe new edition of this well-established and highly regarded textbook continues to provide the clearest and most comprehensive introduction to the modern state. It examines the state from its historical origins at the birth of modernity to its current jeopardized position in the globalized politics of the 21st Century. The book has been entirely revised and updated throughout, including substantial new material on the financial crisis and the environment. 606 $aState, The 606 $aPolitical science 615 0$aState, The. 615 0$aPolitical science. 676 $a320.1 686 $aMD 4000$2rvk 700 $aPierson$b Christopher.$0119365 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910791921003321 996 $aThe modern state$93756885 997 $aUNINA LEADER 05320nam 2200649Ia 450 001 9910830641003321 005 20230721030648.0 010 $a1-281-32024-2 010 $a9786611320249 010 $a0-470-98874-6 010 $a0-470-99422-3 035 $a(CKB)1000000000401063 035 $a(EBL)350928 035 $a(OCoLC)476169700 035 $a(SSID)ssj0000102932 035 $a(PQKBManifestationID)11108581 035 $a(PQKBTitleCode)TC0000102932 035 $a(PQKBWorkID)10061034 035 $a(PQKB)10096807 035 $a(MiAaPQ)EBC350928 035 $a(EXLCZ)991000000000401063 100 $a20060519d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAnalysis of drug impurities$b[electronic resource] /$fedited by Richard J. Smith and Michael L. Webb 210 $aOxford ;$aAmes, Iowa $cBlackwell$d2007 215 $a1 online resource (290 p.) 225 1 $aAnalytical chemistry series 300 $aDescription based upon print version of record. 311 $a1-4051-3358-9 320 $aIncludes bibliographical references and index. 327 $aAnalysis of Drug Impurities; Contents; Preface; List of contributors; 1 Organic impurities in drug substance: origin, control, and measurement; 1.1 Introduction; 1.2 Origin of impurities; 1.2.1 Process impurities; 1.2.2 Degradation impurities; 1.2.3 Contamination impurities; 1.2.4 Other impurities; 1.3 Control of drug substance impurities; 1.3.1 Control of residual solvents; 1.3.2 Control of synthetic impurities; 1.3.3 Control of impurities in biological and botanical products; 1.3.4 Purification processes; 1.3.5 Control of impurities from packaging; 1.3.6 Control of contamination impurities 327 $a1.3.7 Control of degradants on stability1.4 Measurement of drug substance impurities; 1.4.1 HPLC; 1.4.2 GC; 1.4.3 CE; 1.4.4 General considerations; 1.5 Conclusions; Disclaimer; References; 2 Organic impurities in drug products: origin, control and measurement; 2.1 Introduction; 2.2 Analytical methodology; 2.3 Drug-excipient compatibility experimental design; 2.4 Degradation mechanisms; 2.5 Excipients' role in drug product destabilisation; 2.6 Processing as a source of moisture; 2.7 Hydrolysis; 2.8 Oxidation; 2.9 Photolysis; 2.10 Impact of processing on photostability 327 $a2.11 Miscellaneous reactions2.12 Container-closure systems; References; 3 Stereochemical impurities; 3.1 Introduction; 3.2 Separation techniques: direct resolution; 3.2.1 HPLC using CSPs; 3.2.2 HPLC using chiral mobile-phase additives; 3.2.3 Capillary electrophoresis using chiral selectors; 3.2.4 Supercritical fluid chromatography using chiral stationary phases; 3.2.5 Gas chromatography using chiral stationary phases; 3.3 Separation techniques: indirect resolution; 3.4 Non-separation techniques; 3.4.1 Chiroptical spectroscopy; 3.4.2 Nuclear magnetic resonance spectroscopy; 3.5 Conclusions 327 $aAcknowledgementsReferences; 4 Low-level measurement of potent toxins; 4.1 Introduction; 4.2 Classes of genotoxic impurity; 4.2.1 Alkylating agents; 4.2.2 Reactive amines; 4.2.3 Fused tricyclics; 4.2.4 Substituted purines and pyrimidines; 4.2.5 Hydroperoxides; 4.3 The analytical challenge of genetic; 4.4 Gas chromatography; 4.4.1 Sample introduction techniques; 4.4.2 Detectors; 4.5 High-performance liquid chromatography; 4.5.1 Separation modes; 4.5.2 Detection techniques; 4.6 Supercritical fluid chromatography; 4.7 Thin-layer chromatography; 4.8 Sample pre-concentration 327 $a4.8.1 Liquid-liquid extraction4.8.2 Solid-phase extraction; 4.8.3 Solid-phase microextraction; 4.8.4 Liquid-phase microextraction; 4.9 Other techniques; 4.9.1 Electrochemical measurements; 4.9.2 Derivatisation methods; 4.10 Adapting analytical methods from fields beyond pharmaceuticalsimpurities analysis; 4.10.1 Antineoplastic agents; 4.10.2 Other fields; 4.11 Validation of trace analytical methods; 4.11.1 Sensitivity; 4.11.2 Specificity; 4.11.3 Accuracy; 4.11.4 Solution stability; 4.11.5 Linearity and precision; 4.12 Conclusions; References; 5 A systematic approach to impurity identification 327 $a5.1 Introduction 330 $aA key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods.Written for both practic 410 0$aAnalytical chemistry series. 606 $aDrugs$xAnalysis 606 $aMateria medica 615 0$aDrugs$xAnalysis. 615 0$aMateria medica. 676 $a615.1901 676 $a615/.1901 701 $aSmith$b Richard J$0118377 701 $aWebb$b Michael L$092608 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830641003321 996 $aAnalysis of drug impurities$92202139 997 $aUNINA LEADER 01404nas 2200469-a 450 001 9910400560303321 005 20240911213022.0 035 $a(DE-599)ZDB2227148-X 035 $a(CKB)110985822452458 035 $a(CONSER)---83644890- 035 $a(EXLCZ)99110985822452458 100 $a19800123b19781979 --- b 101 0 $aspa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEstudios sefardíes $erevista del Instituto "Arias Montano." 210 $aMadrid $cC.S.I.C.$d1978-1979 215 $a1 online resource 311 08$aPrint version: Estudios sefardíes : 0210-9077 (DLC) 83644890 (OCoLC)5907409 517 1 $aESef 531 0 $aEstud. sefard. 606 $aLadino philology$vPeriodicals 606 $aSephardim$vPeriodicals 606 $aLadino philology$2fast 606 $aSephardim$2fast 606 $aLadino philology$vPeriodicals$2nli 606 $aSephardim$vPeriodicals$2nli 608 $aPeriodicals.$2fast 608 $aPeriodicals.$2lcgft 615 0$aLadino philology 615 0$aSephardim 615 7$aLadino philology. 615 7$aSephardim. 615 7$aLadino philology 615 7$aSephardim 712 02$aInstituto "Arias Montano". 906 $aJOURNAL 912 $a9910400560303321 920 $aexl_impl conversion 996 $aEstudios sefardíes$92238724 997 $aUNINA