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100   $a20071018d2007      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aAcetaldehyde-related pathology$b[electronic resource] $ebridging the trans-disciplinary divide /$f[chair, Peter Emery]
205   $a8th ed.
210   $aChichester ;$aHoboken, N.J. $cJohn Wiley$d2007
215   $a1 online resource (287 p.)
225 1 $aNovartis Foundation symposium ;$v285
300   $aEditors: Derek J. Chadwick and Jamie Goode.
311   $a0-470-05766-1 
320   $aIncludes bibliographical references and indexes.
327   $aAcetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide; Contents; Chair's introduction; Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes; Removal of acetaldehyde from the body; Acetaldehyde, polymorphisms and the cardiovascular system; Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models; Interrelationship between alcohol, smoking, acetaldehyde and cancer; Effects of acetaldehyde on human airway constriction and inflammation
327   $aThe role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tractThe determination of acetaldehyde in exhaled breath; Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain; Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde; Alcoholic myopathy and acetaldehyde; Acetaldehyde adducts in circulation; General discussion; Pancreatic MAP kinase pathways and acetaldehyde; Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes
327   $aEndogenous a-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damageMeasurement of acetaldehyde: what levels occur naturally and in response to alcohol?; Final discussion; Contributors Index; Subject index
330   $aPart of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer's. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of 
410  0$aNovartis Foundation symposium ;$v285.
606   $aAcetaldehyde$xToxicology
610 1 $aAcetaldehyde related pathology
610 1 $aTrans-disciplinary divide
610 2 $aNovartis
615  0$aAcetaldehyde$xToxicology.
676   $a615.952
701   $aEmery$b Peter$f1953-$01612539
701   $aChadwick$b Derek$091632
701   $aGoode$b Jamie$0283336
712 02$aNovartis Foundation.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910830629903321
996   $aAcetaldehyde-related pathology$93941393
997   $aUNINA