LEADER 04522nam 2200685Ia 450 001 9910830576303321 005 20230422044848.0 010 $a1-282-34817-5 010 $a9786612348174 010 $a0-470-51573-2 010 $a0-470-51574-0 035 $a(CKB)1000000000377298 035 $a(EBL)470538 035 $a(OCoLC)609849482 035 $a(SSID)ssj0000311935 035 $a(PQKBManifestationID)11925239 035 $a(PQKBTitleCode)TC0000311935 035 $a(PQKBWorkID)10347187 035 $a(PQKB)10116031 035 $a(MiAaPQ)EBC470538 035 $a(EXLCZ)991000000000377298 100 $a19990716d1999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTransport and trafficking in the malaria-infected erthrocyte$b[electronic resource] /$f[editors, Gregory R. Bock and Gail Cardew] 210 $aChichester ;$aNew York $cJohn Wiley$d1999 215 $a1 online resource (306 p.) 225 1 $aNovartis Foundation symposium ;$v226 300 $a"Symposium on Transport and trafficking in the malaria-infected erythrocyte, held at the Novartis Foundation, London, 26-28 January 1999"--p. v. 311 $a0-471-99893-1 320 $aIncludes bibliographical references and index. 327 $aTRANSPORT AND TRAFFICKING IN THE ERYTHROCYTE MALARIA-INFECTED; Contents; Participants; Introduction: host-parasite interrelations in the genomic age; Erythrocyte membrane transport; Chemical and physical in vitro alterations of the erythrocyte membrane: a model for its pathophysiological states?; The effects of transport perturbations on the homeostasis of erythrocytes; Transport properties of the host cell membrane; Transport of phospholipid synthesis precursors and lipid trafficking into malaria-infected erythrocytes; A nutrient-permeable channel on the intraerythrocytic malaria parasite 327 $aThe permeability properties of the parasite cell membraneMacromolecular transport in malaria-infected erythrocytes; Expression of parasite transporters in Xenopus oocytes; Reconstitution of protein transport across the vacuolar membrane in P Zusmodium fu Zc@urum-infected permeabilized erythrocytes; Export of parasite proteins to the erythrocyte cytoplasm: secretory machinery and traffic signals; Transport and trafficking: Toxoplasma as a model for PZasmodium; An alternative secretory pathway in Pkusmodium: more questions than answers 327 $aThe transport of the histidine-rich protein I from Plasmodium falczarum is insensitive to brefeldin AProtein transport in the host cell cytoplasm and ATP-binding cassette proteins in Plasmodium fukiparum- infected erythrocytes; General discussion I; Chloroquine uptake and activity is determined by binding to ferriprotoporphyrin IX in Plasmodium f a lciparum; Chloroquine uptake, altered partitioning and the basis of drug resistance: evidence for chloride- dependent ionic regulation; Surnrnarv; Index of contributors; Subject index 330 $aThere is an urgent need to uncover new therapies that will protect against malaria, as the parasite becomes increasingly resistant to available drugs and this book offers insights into three interrelated aspects of the malaria-infected erythrocyte:* The transport of solutes into and out of the infected cell and the use of specific trafficking pathways in drug targeting* The traffic of proteins produced by the intracellular parasite as an essential process for the biogenesis of transport systems.* The relationship between the transport of drugs into the infected cell and 410 0$aNovartis Foundation symposium ;$v226. 606 $aMalaria$xPathophysiology$vCongresses 606 $aErythrocyte membranes$vCongresses 606 $aBiological transport$vCongresses 606 $aPlasmodium falciparum$vCongresses 615 0$aMalaria$xPathophysiology 615 0$aErythrocyte membranes 615 0$aBiological transport 615 0$aPlasmodium falciparum 676 $a616.9 676 $a616.936207 701 $aBock$b Gregory$0322650 701 $aCardew$b Gail$0857118 712 02$aNovartis Foundation. 712 12$aSymposium on Transport and Trafficking in the Malaria-Infected Erythrocyte$f(1999 :$eLondon, England) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830576303321 996 $aTransport and trafficking in the malaria-infected erthrocyte$94085365 997 $aUNINA