LEADER 00844nam0-2200301---450 001 990006047250403321 005 20221025173751.0 010 $a3-428-03350-7 035 $a000604725 035 $aFED01000604725 035 $a(Aleph)000604725FED01 100 $a20000112d1975----km-y0itay50------ba 101 0 $ager 102 $aDE 105 $ay---n---001yy 200 1 $aAmtsverbrechen$fvon Heinz Wagner 210 $aBerlin$cDuncker & Humblot$d1975 215 $a423 p.$d23 cm 225 1 $aStrafrechtliche abhandlungen$iNeue Folge$fhrsg. von Eberhard Schmidhäuser$v24 676 $a345$v20$zita 700 1$aWagner,$bHeinz$0403898 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006047250403321 952 $aXII G 125 (24)$b2008*$fFGBC 959 $aFGBC 996 $aAmtsverbrechen$9577605 997 $aUNINA LEADER 04674oam 2201129zu 450 001 9910830570703321 005 20230124181746.0 010 $a1-280-55673-0 010 $a9786610556731 010 $a0-471-65615-1 010 $a0-471-65616-X 035 $a(CKB)1000000000019046 035 $a(SSID)ssj0000303502 035 $a(PQKBManifestationID)11212041 035 $a(PQKBTitleCode)TC0000303502 035 $a(PQKBWorkID)10275576 035 $a(PQKB)10119555 035 $a(MiAaPQ)EBC4957569 035 $a(Au-PeEL)EBL4957569 035 $a(CaONFJC)MIL55673 035 $a(OCoLC)1024283262 035 $a(EXLCZ)991000000000019046 100 $a20160829d2004 uy 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular cancer therapeutics : strategies for drug discovery and development 210 31$a[Place of publication not identified]$cWiley Liss$d2004 215 $a1 online resource (362 pages) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-471-43202-4 330 $aMolecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer.; Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns. 606 $aCancer$xChemotherapy 606 $aCancer$xImmunotherapy 606 $aAntineoplastic agents$xDevelopment 606 $aPharmacogenetics 606 $aAntineoplastic Agents 606 $aDrug Delivery Systems 606 $aDrug Evaluation 606 $aNeoplasms 606 $aDrug Therapy 606 $aEvaluation Studies as Topic 606 $aTherapeutic Uses 606 $aDiseases 606 $aPharmacology 606 $aGenetics 606 $aInvestigative Techniques 606 $aPharmacologic Actions 606 $aTherapeutics 606 $aBiology 606 $aHealth Occupations 606 $aBiological Science Disciplines 606 $aChemical Actions and Uses 606 $aAnalytical, Diagnostic and Therapeutic Techniques and Equipment 606 $aNatural Science Disciplines 606 $aDisciplines and Occupations 606 $aChemicals and Drugs 606 $aOncology$2HILCC 606 $aMedicine$2HILCC 606 $aHealth & Biological Sciences$2HILCC 615 0$aCancer$xChemotherapy 615 0$aCancer$xImmunotherapy 615 0$aAntineoplastic agents$xDevelopment 615 2$aPharmacogenetics 615 2$aAntineoplastic Agents 615 2$aDrug Delivery Systems 615 2$aDrug Evaluation 615 2$aNeoplasms 615 2$aDrug Therapy 615 2$aEvaluation Studies as Topic 615 2$aTherapeutic Uses 615 2$aDiseases 615 2$aPharmacology 615 2$aGenetics 615 2$aInvestigative Techniques 615 2$aPharmacologic Actions 615 2$aTherapeutics 615 2$aBiology 615 2$aHealth Occupations 615 2$aBiological Science Disciplines 615 2$aChemical Actions and Uses 615 2$aAnalytical, Diagnostic and Therapeutic Techniques and Equipment 615 2$aNatural Science Disciplines 615 2$aDisciplines and Occupations 615 2$aChemicals and Drugs 615 7$aOncology 615 7$aMedicine 615 7$aHealth & Biological Sciences 676 $a616.99/4061 702 $aPrendergast$b George C 801 0$bPQKB 906 $aBOOK 912 $a9910830570703321 996 $aMolecular cancer therapeutics : strategies for drug discovery and development$94085324 997 $aUNINA