LEADER 04552nam 2200589 450 001 9910830561803321 005 20211014220407.0 010 $a3-527-65269-8 010 $a3-527-65272-8 010 $a3-527-65271-X 010 $a9783527652693 035 $a(CKB)3710000000636677 035 $a(EBL)4462555 035 $a(MiAaPQ)EBC4462555 035 $a(PPN)204498791 035 $a(EXLCZ)993710000000636677 100 $a20160413h20162016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aDisordered pharmaceutical materials /$fedited by Marc Descamps 210 1$aWeinheim, Germany :$cWiley-VCH Verlag GmbH & Company KGaA,$d[2016] 210 4$d©2016 215 $a1 online resource (646 p.) 300 $aDescription based upon print version of record. 311 1 $a9783527331253 311 $a3-527-33125-5 320 $aIncludes bibliographical references and index. 327 $aTitle Page; Copyright; Table of Contents; List of Contributors; Chapter 1: Some Facets of Molecular Disorder in Crystalline and Amorphous Pharmaceuticals; 1.1 The Crystal/Amorph Alternative; 1.2 Characteristics of the Disorder in Glass Formers; Acknowledgments; References; Chapter 2: Influence of Disorder on Dissolution; 2.1 Introduction; 2.2 Approaches to Enhance Solubility; 2.3 Measuring the Solubility Advantage of Amorphous Compounds; 2.4 Solid Dispersions; 2.5 Polymer Properties; 2.6 Drug-Polymer Interactions; 2.7 Polymer Concentration; 2.8 Other Formulation Components 327 $a2.9 Formulation Variables2.10 Reliable Measurement of Supersaturation; 2.11 Conclusion; References; Chapter 3: Crystal Imperfections in Molecular Crystals: Physical and Chemical Consequences; 3.1 Introduction; 3.2 General Aspects of Defects in Crystals; 3.3 Role of Imperfections in Reactivity and Stability - Chemistry in the Perfect and Imperfect Lattice; 3.4 Role in Physical Processes; 3.5 Concluding Remarks; References; Chapter 4: Observation and Characterization of Crystal Defects in Pharmaceutical Solids; 4.1 Introduction; 4.2 Techniques for Characterizing Defects within Crystals 327 $a4.3 Techniques for Characterizing Defects Emergent at Crystal Surfaces4.4 Techniques for Quantifying Defect Densities within Crystals; 4.5 The Complementarity of Techniques for Characterizing Defects; 4.6 Summary and Outlook; Acknowledgment; References; Chapter 5: "Enantiomeric Disorder" Pharmaceutically Oriented; 5.1 Introduction; 5.2 Introduction and Lexicon of Specific Terms Used among Chiral Molecules and Chiral Molecular Associations; 5.3 Restrictions in Symmetry Operations Inside Crystal Lattices with an Enantiomeric Excess Different from Zero 327 $a5.4 Impact of Chirality on Phase Diagrams and the Gibbs-Scott Phase Rule5.5 Competitions between Solid Solutions (Impact of Polymorphism on Solid Solutions) Application: Preferential Enrichment; 5.6 Disorder at Level 3 Multiepitaxy between Enantiomers; 5.7 Conclusion and Perspectives; Acknowledgments; References; Chapter 6: Conformational Disorder and Atropisomerism in Pharmaceutical Compounds; 6.1 Premise: Conformational Energy Barriers in Flexible Molecules; 6.2 Conformational Topology and Crystallization of Chain Molecules 327 $a6.3 Conformational Polymorphism and Crystallization of Flexible Molecules6.4 Conformational Flexibility of Ring Molecules: Carbohydrates; 6.5 Hindered Conformational Isomerism: Atropisomerism; 6.6 Conclusion; Acknowledgments; References; Chapter 7: Tautomerism in Drug Delivery; 7.1 Broadband Dielectric Spectroscopy as a Powerful Tool for Investigating the Tautomerization Process in Condensed Materials; 7.2 Tautomerization Kinetics of Supercooled Pharmaceuticals; Acknowledgment; References; Chapter 8: Disorders in Pharmaceutical Polymers; 8.1 Polymers Architectures - Structural Disorders 327 $a8.2 Structural States and Phases Transitions 606 $aMaterials biomèdics$2lemac 606 $aBiotecnologia farmacèutica$2lemac 606 $aPharmaceutical biotechnology 606 $aBiomedical materials 615 7$aMaterials biomèdics. 615 7$aBiotecnologia farmacèutica 615 0$aPharmaceutical biotechnology. 615 0$aBiomedical materials. 702 $aDescamps$b Marc 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830561803321 996 $aDisordered pharmaceutical materials$93939284 997 $aUNINA