LEADER 05396nam 2200721Ia 450 001 9910830554803321 005 20230721030148.0 010 $a1-281-08796-3 010 $a1-282-11841-2 010 $a9786612118418 010 $a9786611087968 010 $a3-527-61147-9 010 $a3-527-61148-7 035 $a(CKB)1000000000376027 035 $a(EBL)481656 035 $a(OCoLC)181348501 035 $a(SSID)ssj0000156367 035 $a(PQKBManifestationID)11163136 035 $a(PQKBTitleCode)TC0000156367 035 $a(PQKBWorkID)10123604 035 $a(PQKB)11615160 035 $a(MiAaPQ)EBC481656 035 $a(MiAaPQ)EBC4956418 035 $a(Au-PeEL)EBL4956418 035 $a(CaONFJC)MIL108796 035 $a(OCoLC)1027143548 035 $a(EXLCZ)991000000000376027 100 $a20070906d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFoldamers$b[electronic resource] $estructure, properties, and applications /$fedited by Stefan Hecht and Ivan Huc ; foreword by Franc?ois Diederich 210 $aWeinheim $cWiley-VCH$dc2007 215 $a1 online resource (459 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31563-2 320 $aIncludes bibliographical references and index. 327 $aFoldamers; Foreword; Contents; Preface; List of Contributors; Part 1 Structure: Foldamer Design Concepts; 1 Foldamers Based on Local Conformational Preferences; 1.1 Introduction; 1.2 Rigidly Locked Molecules; 1.3 Predictable Foldamers; 1.3.1 Local Conformational Control; 1.3.2 Folded Conformations of ?-conjugated Systems; 1.3.2.1 Crescents and Helices; 1.3.2.2 Linear Strands; 1.3.2.3 Macrocycles; 1.3.3 Partially ?-conjugated Oligomers; 1.4 Semi-rigid Backbones; 1.4.1 Tertiary Aromatic Amides, Imides and Ureas; 1.4.2 Tertiary Aliphatic Amides: Polyprolines and Peptoids 327 $a1.4.3 Hindered Polymer and Oligomer Backbones1.5 Conformational Transitions; 1.6 Conclusion and Perspectives; References; 2 Foldamers Based on Remote Intrastrand Interactions; 2.1 Introduction; 2.2 What can be Learned from Strategies used to Control Conformations of ?-Polypeptides?; 2.3 Helices from Homogeneous Oligomeric Backbones with Periodicity at the Monomer Level: ?-Peptides and their Analogs; 2.3.1 Compact Helices with Large (>10 atoms) H-bonded Rings; 2.3.1.1 The Homologation Strategy: ?- and ?-Peptide Foldamers 327 $a2.3.1.2 Imposing Backbone Conformational Restriction/Pre-organization for Optimal Helical Folding2.3.1.3 Folding in an Aqueous Environment; 2.3.1.4 Dynamics of ?- and ?-Peptide Helices: Evidence for Noncooperative Folding/Unfolding Processes; 2.3.2 Extended Helices with Small H-bonded Rings Centered at a Single Residue; 2.3.2.1 ?-Peptides: the ?-Helix; 2.3.2.2 ?-Peptides with Specific Conformation-stabilizing Elements; 2.3.2.3 Stabilizing Local Backbone Conformation by Inverse-Bifurcation Involving an Additional Heteroatom; 2.4 Oligoamide Mixed Helices 327 $a2.4.1 The ?-Oligopeptide Precedent: from Antibiotic Gramicidin A to Poly-Gln Aggregates in Huntington's Disease2.4.2 Introducing Periodicity at the Level of a Dimer Unit in ?-Peptides leads to a Remarkably Stable Mixed Helical Fold; 2.4.2.1 By Mixing ?(2)- and ?(3)-Amino Acids; 2.4.2.2 Additional Substitution Patterns Stabilizing the Mixed 10/12- (12/10-) Helix; 2.4.3 Extending the Concept of Mixed Helices; 2.5 Nonperiodic Structures: Open Chain ?-Turn-like Motifs and Hairpins in Designed Homo-oligomers; 2.5.1 Sheet-forming ?-peptides; 2.5.2 Turn Segment for Hairpin Formation 327 $a2.6 Expanding Structural Diversity with Heterogeneous Backbones2.6.1 From Discrete ?-Amino Acid Guests in ?-Helices to Helical ?,?- and ?,?-Peptide Hybrids; 2.6.2 Hairpins from ?,?-Peptide Hybrids; 2.6.3 Sculpting New Shapes by Integrating H-Bonding, Aromatic Interactions and Multiple Levels of Pre-organization; 2.7 Conclusion and Outlook; References; 3 Foldamers Based on Solvophobic Effects; 3.1 Introduction; 3.2 Learning from Solvophobically Driven Assemblies - Intermolecular Solvophobic Interactions; 3.3 Learning from Synthetic and Biological Polymers 327 $a3.4 Recent Advances in Foldamers Based on Solvophobic Effects 330 $aThis truly comprehensive treatise of foldamers, from synthesis to applications in bio-, material-, and nanoscience is at once an introduction to the topic, while providing in-depth accounts on various aspects clearly aimed at the specialist.The book is clearly structured, with the first part concentrating on structure and foldamer design concepts, while the second part covers functional aspects from properties to applications. The international team of expert authors provides overviews of synthetic approaches as well as analytical techniques. 606 $aChemistry, Technical 606 $aMolecules$xModels 606 $aOligomers 615 0$aChemistry, Technical. 615 0$aMolecules$xModels. 615 0$aOligomers. 676 $a541 676 $a547.7 701 $aHecht$b Stefan$f1974-$01646627 701 $aHuc$b Ivan$01646628 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830554803321 996 $aFoldamers$93993732 997 $aUNINA