LEADER 04406nam 22006374a 450 001 9910830549003321 005 20230617024543.0 010 $a1-280-27406-9 010 $a9786610274062 010 $a0-470-87161-X 010 $a0-470-87162-8 035 $a(CKB)111087027098534 035 $a(EBL)219736 035 $a(SSID)ssj0000161463 035 $a(PQKBManifestationID)11183409 035 $a(PQKBTitleCode)TC0000161463 035 $a(PQKBWorkID)10199258 035 $a(PQKB)10363702 035 $a(MiAaPQ)EBC219736 035 $a(OCoLC)54511024 035 $a(EXLCZ)99111087027098534 100 $a20030724d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGeneration and effector functions of regulatory lymphocytes$b[electronic resource] /$f[editors, Gregory Bock and Jamie Goode] 210 $aHoboken, N.J. $cWiley$dc2003 215 $a1 online resource (327 p.) 225 1 $aNovartis Foundation symposium ;$v252 300 $aDescription based upon print version of record. 311 $a0-470-85074-4 320 $aIncludes bibliographical references and index. 327 $aGENERATION AND EFFECTOR FUNCTIONS OF REGULATORY LYMPHOCYTES; Contents; Participants; Chair's introduction; Thymic generation and selection of CD25(+)CD4(+) regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance; Discussion; Control of T cell activation by CD4(+)CD25(+) suppressor T cells; Discussion; Regulation of experimental autoimmune encephalomyelitis (EAE) by CD4(+)CD25(+) regulatory T cells; Discussion; The role of CD28 and CTLA4 in the function and homeostasis of CD4(+)CD25(+) regulatory T cells 327 $aDiscussionCD4(+)CD25(+) regulatory cells from human peripheral blood express very high levels of CD25 ex vivo; Discussion; Control of immune pathology by regulatory T cells; Discussion; General discussion I TGFB; Type 1 T regulatory cells and their relationship with CD4(+)CD25(+) T regulatory cells; Discussion; (PRO)insulin-specific regulatory T cells; Discussion; CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetes; Discussion 327 $aSeven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune systemDiscussion; Regulatory cells in transplantation; Discussion; CD4(+) regulatory T cells in chronic viral infection; Discussion; General discussion II; Modulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship; Discussion; Dendritic cells: controllers of the immune system and a new promise for immunotherapy; Discussion; Regulation of viral and autoimmune responses; Discussion; General discussion III Active immune regulation 327 $aNotch signalling in the peripheral immune systemDiscussion; CD3 antibody treatment stimulates the functional capability of regulatory T cells; Discussion; The role of dendritic cells in regulating mucosal immunity and tolerance; Discussion; Index of contributors; Subject index 330 $aOver the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are 410 0$aNovartis Foundation symposium ;$v252. 606 $aLymphocytes 606 $aT cells 606 $aImmune response$xRegulation 615 0$aLymphocytes. 615 0$aT cells. 615 0$aImmune response$xRegulation. 676 $a571.96 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830549003321 996 $aGeneration and effector functions of regulatory lymphocytes$93993688 997 $aUNINA