LEADER 02447nam 22005534a 450 001 9910830463003321 005 20230721030235.0 010 $a1-282-34870-1 010 $a9786612348709 010 $a0-470-51665-8 010 $a0-470-51664-X 035 $a(CKB)1000000000377226 035 $a(EBL)470311 035 $a(OCoLC)723943532 035 $a(SSID)ssj0000297181 035 $a(PQKBManifestationID)11224577 035 $a(PQKBTitleCode)TC0000297181 035 $a(PQKBWorkID)10328488 035 $a(PQKB)10142932 035 $a(MiAaPQ)EBC470311 035 $a(EXLCZ)991000000000377226 100 $a20070608d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aG protein-coupled receptors$b[electronic resource] $emolecular pharmacology from academic concept to pharmaceutical research /$fGeorges Vauquelin, Bengt von Mentzer 210 $aChichester, England ;$aHoboken, NJ $cJohn Wiley & Sons$dc2007 215 $a1 online resource (266 p.) 300 $aDescription based upon print version of record. 311 $a0-470-51647-X 320 $aIncludes bibliographical references (p. [235]-243) and index. 327 $aChemical messengers and the cell membrane -- Radioligand binding studies -- Functional studies -- G protein-coupled receptors -- Concluding remarks. 330 $aG protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly. G Protein-coupled Receptors: Molecular Pharmacology provi 606 $aG proteins$xReceptors 606 $aMolecular pharmacology 615 0$aG proteins$xReceptors. 615 0$aMolecular pharmacology. 676 $a615.19 700 $aVauquelin$b Georges$01663508 701 $aMentzer$b Bengt von$01663509 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830463003321 996 $aG protein-coupled receptors$94020874 997 $aUNINA