LEADER 04804nam 2200661Ia 450 001 9910830431203321 005 20230421045203.0 010 $a1-282-02538-4 010 $a9786612025389 010 $a3-527-61605-5 010 $a3-527-61604-7 035 $a(CKB)1000000000578771 035 $a(EBL)482244 035 $a(OCoLC)310352007 035 $a(SSID)ssj0000101645 035 $a(PQKBManifestationID)11127015 035 $a(PQKBTitleCode)TC0000101645 035 $a(PQKBWorkID)10043026 035 $a(PQKB)10542837 035 $a(MiAaPQ)EBC482244 035 $a(EXLCZ)991000000000578771 100 $a19931109d1994 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAlternatives to animal testing$b[electronic resource] $enew ways in the biomedical sciences, trends and progress /$fedited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT 210 $aWeinheim ;$aNew York $cVCH$dc1994 215 $a1 online resource (202 p.) 300 $aPapers from a symposium held at the ETH, Zurich on Nov. 30, 1992, and updated to include developments through fall 1993. 311 $a3-527-30043-0 320 $aIncludes bibliographical references and index. 327 $aAlternatives to Animal Testing; Preface; In memoriam; Foreword; List of contributors; Contents; 1 Looking Back 33 Years to Russell and Burch: The Development of the Concept of the Three Rs (Alternatives); 2 The OECD and International Regulatory Acceptance of the Three Rs; 3 The European Centre for the Validation of Alternative Methods (ECVAM); 4 A Timetable for Replacing, Reducing and Refining Animal Use with the Help of in Vitro Tests: The Limulus Amebocyte Lysate Test (LAL) as an Example 327 $a5 The Fund for the Replacement of Animals in Medical Experiments (FRAME): 23 Years of Campaigning for the Three Rs6 Animal Use and Alternatives: Developments in the Netherlands; 7 The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines; 8 ZEBET: Three Years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin; 9 Reviewed Literature Databank for Alternatives to Animal Experiments - "Gelbe Liste" 327 $a10 The SIAT Research, Teaching and Consulting Program in the Area of in Vitro Toxicology. Experimental Research, Screening and Validation11 Computer-Aided Drug Design and the Three Rs; 12 Computer-Aided Programs in Biomedical Education; 13 Alternatives to Experiments with Animals in Medical Education: A TEMPUS Joint European Project; 14 Replacement of Laboratory Animals in the Management of Blood- Sucking Arthropods; 15 Maintenance of Filarial Cycles in the Laboratory: Approaches to Replacing the Vertebrate Host 327 $a16 Improved Drug Metabolizing Capacity of Hepatocytes Co-Cultured with Epithelial Cells and Maintained in a Perifusion System17 Characterization and Use of Long-Term Liver Cultures to Evaluate the Toxicity of Cyclophosphamide or Benzene to Bone Marrow Cultures; 18 European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin2TM Model ZK1100) Using 18 Chemicals and Formulated Products; 19 Cellular Assays for Testing Peritoneal Dialysis Bags; 20 The Position of the Authorities; Subject index 330 $aOpinion leaders in science and politics examine findings and legislation in alternatives to animal testing!Refine, reduce, replace - These are the three demands that scientists have placed upon themselves in their search for alternatives to animal testing. Indeed much interdisciplinary research is being carried on today, and new fields have emerged, such as in-vitro toxicology. The three R's call for new scientific insights. Moreover, validation and acceptance strategies have to be adapted, a process of much ongoing interest and vital concern to the pharmaceutical and cosmetic 606 $aAlternative toxicity testing$vCongresses 606 $aAnimal experimentation$vCongresses 606 $aTests de toxicitat$2thub 606 $aExperimentació animal$2thub 608 $aCongressos$2thub 608 $aLlibres electrònics$2thub 615 0$aAlternative toxicity testing 615 0$aAnimal experimentation 615 7$aTests de toxicitat 615 7$aExperimentació animal 676 $a619 701 $aReinhardt$b Christoph A$0974294 712 02$aSwiss Institute for Alternatives to Animal Testing. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830431203321 996 $aAlternatives to animal testing$92218145 997 $aUNINA