LEADER 03952nam 2200673Ia 450 001 9910830425403321 005 20230721030215.0 010 $a1-282-12387-4 010 $a9786612123870 010 $a0-470-98557-7 010 $a0-470-98556-9 035 $a(CKB)1000000000377303 035 $a(EBL)470483 035 $a(SSID)ssj0000360016 035 $a(PQKBManifestationID)11244187 035 $a(PQKBTitleCode)TC0000360016 035 $a(PQKBWorkID)10317795 035 $a(PQKB)10624946 035 $a(MiAaPQ)EBC470483 035 $a(OCoLC)184983387 035 $a(EXLCZ)991000000000377303 100 $a20070626d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFatty acids and lipotoxicity in obesity and diabetes$b[electronic resource] /$feditors: Gregory Bock and Jamie Goode 210 $aLondon $cJohn Wiley$d2007 215 $a1 online resource (223 p.) 225 1 $aNovartis Foundation symposium ;$v286 300 $aDescription based upon print version of record. 311 $a0-470-05764-5 320 $aIncludes bibliographical references and index. 327 $aFATTY ACIDS AND LIPOTOXICITY IN OBESITY AND DIABETES; Contents; Chair's introduction; Transcriptional control of energy homeostasis through the PGC1 coactivators; DISCUSSION; Human obesity and insulin resistance: lessons from experiments of nature; DISCUSSION; Lipid-induced metabolic dysfunction in skeletal muscle; DISCUSSION; Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes; DISCUSSION; The role of lipin 1 in adipogenesis and lipid metabolism; DISCUSSION; The role of the AMP-activated protein kinase in the regulation of energy homeostasis; DISCUSSION 327 $aEndoplasmic reticulum stress and inflammation in obesity and type 2 diabetesDISCUSSION; The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis; DISCUSSION; Fatty acid transport in adipocytes and the development of insulin resistance; DISCUSSION; Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking; DISCUSSION; Lipid storage and mobilization pathways in yeast; DISCUSSION; Cide proteins and the development of obesity; DISCUSSION; General discussion I; Visualizing brown adipose tissue with FDG-PET 327 $aAdiponectin and adiponectin receptors in obesity-linked insulin resistanceDISCUSSION; Anti-inflammatory and antidiabetic roles of PPARy; DISCUSSION; Final Discussion; Nutrition, ageing and lipotoxicity; Contributor Index; Subject Index 330 $aThe potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic ß cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics in 410 0$aNovartis Foundation symposium ;$v286. 606 $aLipids$xMetabolism$vCongresses 606 $aFatty acids$vCongresses 606 $aAdipose tissues$vCongresses 606 $aObesity$vCongresses 606 $aDiabetes$vCongresses 615 0$aLipids$xMetabolism 615 0$aFatty acids 615 0$aAdipose tissues 615 0$aObesity 615 0$aDiabetes 676 $a612.397 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830425403321 996 $aFatty acids and lipotoxicity in obesity and diabetes$94013865 997 $aUNINA