LEADER 05263nam 2200709 450 001 9910830413303321 005 20170919023051.0 010 $a1-5231-1471-1 010 $a1-118-69629-8 010 $a1-118-69628-X 035 $a(CKB)3710000000603852 035 $a(EBL)4413719 035 $a(SSID)ssj0001624182 035 $a(PQKBManifestationID)16362052 035 $a(PQKBTitleCode)TC0001624182 035 $a(PQKBWorkID)14930352 035 $a(PQKB)10068168 035 $a(PQKBManifestationID)16362213 035 $a(PQKB)20962508 035 $a(MiAaPQ)EBC4413719 035 $a(DLC) 2015024602 035 $a(PPN)226648346 035 $a(EXLCZ)993710000000603852 100 $a20150618d2016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPractical methods for biocatalysis and biotransformations$h3 /$fedited by John Whittall, Manchester Interdisciplinary Biocentre (MIB), The University of Manchester, UK, Peter W. Sutton, GlaxoSmithKline Research and Development Limited, UK, Wolfgang Kroutil, Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria 205 $a3. 210 1$aChichester, West Sussex :$cJohn Wiley & Sons, Limited,$d2016. 215 $a1 online resource (319 p.) 300 $aDescription based upon print version of record. 311 $a1-118-69785-5 311 $a1-118-60525-X 320 $aIncludes bibliographical references and index. 327 $aPractical Methods for Biocatalysis and Biotransformations 3; Contents; List of Contributors; Abbreviations; Chapter 1: Considerations for the Application of Process Technologies in Laboratory- and Pilot-Scale Biocatalysis for Chemical Synthesis; 1.1 Introduction; 1.2 Process Intensification and Proposed Scale-Up Concept; 1.3 Enabling Technologies; 1.3.1 Biocatalyst Immobilization; 1.3.1.1 General Considerations for Implementation; 1.3.1.2 Carrier-Bound Supported Enzymes; 1.3.1.2.1 Adsorption; Considerations for Implementation; 1.3.1.2.2 Covalent Binding; Considerations for Implementation 327 $a1.3.1.2.3 Ionic BindingConsiderations for Implementation; 1.3.1.3 Carrier-Free Immobilization; 1.3.1.3.1 Cross-Linked Enzyme Aggregates (CLEAsTM); Considerations for Implementation; 1.3.2 Reactor Options; 1.3.2.1 Ideal Reactors; 1.3.2.2 Modes of Operation; 1.3.2.3 Well-Mixed Reactor Hydrodynamics; 1.3.2.3.1 Stirred Tanks; Considerations for Implementation; 1.3.2.3.2 Batch Stirred-Tank Reactors (BSTRs); Considerations for Implementation; 1.3.2.3.3 Continuous Stirred-Tank Reactors (CSTRs); Considerations for Implementation; 1.3.2.3.4 Alternative Well-Mixed Reactors 327 $aContinuous Fluidized-Bed Reactors (CFBRs)Considerations for Implementation; Continuous Packed-Bed Reactors (CPBRs); Considerations for Implementation; Continuous Expanded-Bed Reactors (CEBRs); Considerations for Implementation; 1.3.2.3.5 Membrane Bioreactors (MBRs); Considerations for Implementation; 1.4 Enhancing Technologies; 1.4.1 In Situ Product Removal (ISPR); 1.4.1.1 Considerations for Implementation; 1.4.1.2 ISPR by Adsorption on Resins; 1.4.1.2.1 Considerations for Implementation; 1.4.1.3 ISPR Using Expanded-Bed Adsorption (EBA); 1.4.1.3.1 Considerations for Implementation 327 $a1.4.1.4 ISPR by Crystallization1.4.1.4.1 Considerations for Implementation; 1.4.2 Substrate Feeding Strategies; 1.4.2.1 Fed-Batch Operation; 1.4.2.1.1 Considerations for Implementation; 1.4.3 Non-Conventional Media; 1.4.3.1 Single Non-Conventional Liquid Phase Systems; 1.4.3.1.1 Considerations for Implementation; 1.4.3.2 Aqueous-Organic Two-Liquid Phase Systems; 1.4.3.2.1 Considerations for Implementation; 1.4.3.3 Aqueous-Ionic Liquid Two-Liquid Phase Systems; 1.4.3.3.1 Considerations for Implementation; 1.4.4 Oxygen Supply Strategies; 1.4.4.1 Surface Aeration 327 $a1.4.4.1.1 Considerations for Implementation1.4.4.2 Sparged Aeration; 1.4.4.2.1 Considerations for Implementation; 1.4.4.3 Bubble-Column Reactors; 1.4.4.3.1 Considerations for Implementation; 1.5 Conclusion; References; Chapter 2: Cytochrome P450 (CYP) Progress in Biocatalysis for Synthetic Organic Chemistry; 2.1 Introduction; 2.2 CYP Development; 2.3 Recent Developments; 2.4 Conclusion; References; Chapter 3: Use of Hydrolases and Related Enzymes for Synthesis; 3.1 Continuous-Flow Reactor-Based Enzymatic Synthesis of Phosphorylated Compounds on a Large Scale; 3.1.1 Materials and Equipment 327 $a3.1.2 Immobilization of Acid Phosphatase on Immobeads 606 $aEnzymes$xBiotechnology 606 $aBiocatalysis 606 $aBiotransformation (Metabolism) 606 $aOrganic compounds$xSynthesis 615 0$aEnzymes$xBiotechnology. 615 0$aBiocatalysis. 615 0$aBiotransformation (Metabolism) 615 0$aOrganic compounds$xSynthesis. 676 $a660.6/34 702 $aWhittall$b John 702 $aSutton$b Peter$g(Peter W.), 702 $aKroutil$b Wolfgang$f1972- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830413303321 996 $aPractical methods for biocatalysis and biotransformations$93916340 997 $aUNINA