LEADER 04981nam 22006014a 450 001 9910830409203321 005 20230617040630.0 010 $a1-280-51954-1 010 $a9786610519545 010 $a3-527-60466-9 010 $a3-527-60407-3 035 $a(CKB)1000000000377165 035 $a(EBL)482362 035 $a(OCoLC)68571538 035 $a(SSID)ssj0000119183 035 $a(PQKBManifestationID)11129652 035 $a(PQKBTitleCode)TC0000119183 035 $a(PQKBWorkID)10058034 035 $a(PQKB)10264845 035 $a(MiAaPQ)EBC482362 035 $a(EXLCZ)991000000000377165 100 $a20060808d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCell migration in development and disease$b[electronic resource] /$fedited by Doris Wedlich 210 $aWeinheim $cWiley-VCH$dc2005 215 $a1 online resource (399 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30587-4 320 $aIncludes bibliographical references and index. 327 $aCell Migrationin Development and Disease; Contents; Preface; List of Contributors; Color Plates; I Cell Shape Modulations and Cell Surface-Nucleus Connections: Prerequisites for Cell Migration; 1 Functional Phases in Cell Attachment and Spreading; 1.1 Introduction; 1.2 Fibroblast Spreading on Matrices; 1.3 Summary of Spreading Process; 1.3.1 Steps in Cell Spreading; 1.3.1.1 Basal Motility Phase (Cells in Suspension); 1.3.1.2 Adhesion to the Surface; 1.3.1.3 Initiation of Actin Assembly and Spreading (Rate-limiting Step); 1.3.1.4 Continued Spreading; 1.3.1.5 Transition to Fully Spread State 327 $a1.3.2 Binding to Rigid Matrices Causes Strengthening of Cytoskeleton-Integrin Linkages1.3.2.1 Initial Binding of Fibronectin Multimers at the Leading Edge and Over Actin Cables; 1.3.2.2 Force-dependent Activation of the ECM-Integrin Complexes; 1.3.2.3 Additional Steps in the Spreading Process; 1.3.3 MTs and Motility; 1.3.4 Conclusion; 1.4 References; 2 Polarized Cell Motility: Microtubules Show the Way; 2.1 Introduction; 2.1.1 The Vasiliev Conundrum; 2.1.2 Cell Polarity and Adhesion; 2.2 Microtubules Meet the Actin Cytoskeleton at Focal Adhesions 327 $a2.3 Microtubule Targeting Promotes Focal Adhesion Turnover2.4 Contractility, the Functional Link; 2.5 Kinesin and Signal Transmission; 2.6 Tip Complexes Meet Adhesion Complexes; 2.7 Focal Adhesions Influence Microtubule Dynamics; 2.8 Actin Talks Back: Tension and Microtubule Guidance; 2.9 Conclusions and Perspectives; 2.10 Acknowledgments; 2.11 References; 3 Mechanisms of Eukaryotic Chemotaxis; 3.1 Chemotaxis is a Fundamental Cellular Response; 3.2 Directional Sensing Occurs Downstream of G Protein Activation and Upstream of the Accumulation of PI(3,4,5)P(3) 327 $a3.3 Input-Output Relationships Reveal Gradient Amplification in Polarized and Unpolarized Cells3.4 Increase in Local PI(3,4,5)P(3) Precedes Actin Polymerization Responses; 3.5 Positive Feedback and the Actin Cytoskeleton May Stabilize Directional Sensing and Establish Polarity; 3.6 References; 4 Dual Location Proteins: Communication Between Cell Adhesions and the Nucleus; 4.1 Introduction; 4.2 LIM Protein Family; 4.2.1 Zyxin Subfamily; 4.2.1.1 Zyxin; 4.2.1.2 LPP (Lipoma-Prefered Partner); 4.2.1.3 Trip6; 4.2.1.4 WTIP (Wilms Tumor protein 1 Interaction Protein); 4.2.1.5 Ajuba 327 $a4.2.2 Paxillin Subfamily4.2.2.1 Paxillin; 4.2.2.2 Hic-5; 4.3 MAGUK Protein Family; 4.3.1 ZO-1; 4.3.2 ZO-2; 4.3.3 CASK; 4.4 Armadillo Repeat Protein Family; 4.4.1 ?-catenin Armadillo Repeat Subfamily; 4.4.1.1 ?-catenin; 4.4.1.2 Plakoglobin; 4.4.2 p120 Armadillo Repeat Subfamily; 4.4.2.1 p120; 4.4.2.2 ARVCF; 4.4.2.3 Plakophilins; 4.5 Other Proteins - Symplekin; 4.6 Dual Location; 4.6.1 Sequestration of Transcriptional Regulators; 4.6.2 mRNA Localization; 4.6.3 Scaffolding; 4.7 Conclusion; 4.8 Acknowledgments; 4.9 References; II Classical Examples of Cell Migration in Development 327 $a5 Cell Migration During Zebrafish Gastrulation 330 $aCell Migration matches nearly all research areas in cell and developmental biology, genetics, and biomedicine. The field shows radical progress powered by the combination of new genomic tools, cell labeling techniques and the incorporation of new model systems. This is the first book to comprehensively cover cell migration from the identification of molecular mechanisms to the understanding of certain pathological disorders and cancer development. 606 $aCell migration$xDiseases 615 0$aCell migration$xDiseases. 676 $a571.6 676 $a571.8 676 $a571.835 701 $aWedlich$b Doris$01595386 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830409203321 996 $aCell migration in development and disease$93916311 997 $aUNINA LEADER 01412nam 2200397Ia 450 001 9910698263803321 005 20250511161357.0 035 $a(CKB)5410000000480149 035 $a(OCoLC)70008191 035 $a(EXLCZ)995410000000480149 100 $a20060607d1959 ua 0 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSaratoga National Historical Park, New York /$fby Charles W. Snell and Francis F. Wilshin 205 $aRev. 1959. 210 1$aWashington, D.C. :$cU.S. Dept. of the Interior, National Park Service,$d1959. 215 $a1 electronic text $cHTML file 225 1 $aHistorical handbook series ;$vno. 4 225 $aNational Park Service Historical Handbook Series No. 4 300 $aTitle from title screen (viewed on Apr. 24, 2006). 320 $aIncludes bibliographical references. 606 $aSaratoga Campaign, N.Y., 1777 607 $aSaratoga National Historical Park (N.Y.) 607 $aNew York (State)$xHistory$yRevolution, 1775-1783 615 0$aSaratoga Campaign, N.Y., 1777. 700 $aSnell$b Charles W$01351289 701 $aWilshin$b Francis$01382324 712 02$aUnited States.$bNational Park Service. 801 0$bGPO 801 1$bGPO 906 $aBOOK 912 $a9910698263803321 996 $aSaratoga National Historical Park, New York$93428731 997 $aUNINA