LEADER 05440nam 22006974a 450 001 9910830389103321 005 20170815120509.0 010 $a1-280-40909-6 010 $a9786610409099 010 $a0-470-36036-4 010 $a0-471-73934-0 010 $a0-471-73933-2 035 $a(CKB)1000000000355493 035 $a(EBL)255368 035 $a(OCoLC)304135693 035 $a(SSID)ssj0000200618 035 $a(PQKBManifestationID)11203208 035 $a(PQKBTitleCode)TC0000200618 035 $a(PQKBWorkID)10220744 035 $a(PQKB)10769368 035 $a(MiAaPQ)EBC255368 035 $a(PPN)24326576X 035 $a(EXLCZ)991000000000355493 100 $a20060119d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMedicinal chemistry of bioactive natural products$b[electronic resource] /$fedited by Xiao-Tian Liang, Wei-Shuo Fang 210 $aHoboken, N.J. $cWiley-Interscience/John Wiley$dc2006 215 $a1 online resource (482 p.) 300 $aDescription based upon print version of record. 311 $a0-471-66007-8 320 $aIncludes bibliographical references and index. 327 $aMEDICINAL CHEMISTRY OF BIOACTIVE NATURAL PRODUCTS; CONTENTS; Preface; Contributors; 1 The Chemistry and Biology of Epothilones-Lead Structures for the Discovery of Improved Microtubule Inhibitors; 1.1. Introduction; 1.2. Biological Effects of Epo B; 1.2.1 In Vitro Activity; 1.2.2 In Vivo Antitumor Activity; 1.3. Epothilone Analogs and SAR Studies; 1.3.1 Lactam-Based Analogs; 1.3.2 Modifications in the C9-C11 Region; 1.3.3 Modifications of the Epoxide Moiety; 1.3.4 C-26-Modified Analogs; 1.3.5 Side-Chain Modifications; 1.3.6 Aza-Epothilones 327 $a1.4. Pharmacophore Modeling and Conformational Studies1.5. Epothilone Analogs in Clinical Development; 1.6. Conclusions; Acknowledgments; References; 2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives; 2.1. Introduction; 2.2. Classification of Glycopeptide Antibiotics; 2.3. Mode of Action; 2.4. Glycopeptide Resistance; 2.5. Biosynthesis; 2.6. Total Synthesis; 2.7. Glycopeptides as Chiral Selectors in Chromatography and Capillary Electrophoresis; 2.8. Structural Modifications of Glycopeptide Antibiotics and Structure Activity Relationship (SAR) Studies 327 $a2.8.1 Modifications of Glycopeptide Antibiotics2.8.2 Rational Concepts for the Design of Novel Glycopeptides; 2.8.3 Conclusions; Acknowledgment; References; 3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs; 3.1. Discovery and Research and Development of Taxol; 3.2. Paclitaxel Analogs Active Against Normal Tumor Cells; 3.2.1 C-13 Side Chain; 3.2.2 A Ring and Its Substitutions; 3.2.3 B Ring and Its Substitutions; 3.2.4 C Ring and Its Substitutions; 3.2.5 D Ring; 3.2.6 Macrocyclic Analogs; 3.2.7 Miscellaneous 327 $a3.3. Exploration on Mechanism of Paclitaxel Related to Tubulin Binding and Quest for Its Pharmacophore3.3.1 Biochemical Mechanism of Paclitaxel Related to Tubulin Binding; 3.3.2 Identification of Bioactive Conformations and Quest for a Pharmacophore for Paclitaxel; 3.4. Natural and Semisynthetic Taxoids Overcoming Multidrug Resistance (MDR); 3.4.1 Structure-Modified Taxoids With Better Activity Toward MDR Tumors; 3.4.2 Nonpaclitaxel-Type Taxoids With MDR Reversal Activities; 3.4.3 Factors Contributing to the Resistance to Paclitaxel 327 $a3.5 Design, Synthesis and Pharmacological Activity of Prodrugs of Paclitaxel3.5.1 Prodrugs Prepared to Improve Water Solubility; 3.5.2 Prodrugs Designed for Enhancing Specificity; 3.6 Other Biological Actions of Paclitaxel; 3.7 New Antimicrotubule Molecules Mimicking Action of Paclitaxel; 3.8 Conclusion; Acknowledgments; References; 4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer's Disease; 4.1 Introduction; 4.1.1 Powerful AChEI Originated From Traditional Chinese Medicine; 4.1.2 Alzheimer's Disease; 4.2. Profiles of HA; 4.2.1 Discovery of HA 327 $a4.2.2 Physical Appearance of HA 330 $aCurrent discoveries and research into bioactive natural productsMedicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current rese 606 $aMateria medica, Vegetable 606 $aPharmaceutical chemistry 606 $aNatural products 606 $aBioactive compounds 615 0$aMateria medica, Vegetable. 615 0$aPharmaceutical chemistry. 615 0$aNatural products. 615 0$aBioactive compounds. 676 $a615.321 676 $a615/.321 701 $aLiang$b Xiaotian$01680945 701 $aFang$b Wei-Shuo$01680946 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830389103321 996 $aMedicinal chemistry of bioactive natural products$94050011 997 $aUNINA LEADER 12135oam 22005053 450 001 9910823099403321 005 20220831085741.0 010 $a9781118699171$b(electronic bk.) 010 $z9780470659199 035 $a(MiAaPQ)EBC1367693 035 $a(Au-PeEL)EBL1367693 035 $a(CaPaEBR)ebr10753393 035 $a(CaONFJC)MIL514697 035 $a(OCoLC)874399319 035 $a(EXLCZ)9917684653700041 100 $a20220831d2013 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCare of People with Diabetes $eA Manual of Nursing Practice 205 $a4th ed. 210 1$aHoboken :$cJohn Wiley & Sons, Incorporated,$d2013. 210 4$dİ2014. 215 $a1 online resource (610 pages) 311 08$aPrint version: Dunning, Trisha Care of People with Diabetes Hoboken : John Wiley & Sons, Incorporated,c2013 9780470659199 327 $aIntro -- Care of People with Diabetes: A Manual of Nursing Practice -- Copyright -- Contents -- Foreword -- Preface -- Acknowledgements -- List of Abbreviations and Symbols -- 1 Diagnosing and Classifying Diabetes -- Key points -- What is diabetes mellitus? -- Prevalence of diabetes -- Classification of diabetes -- Overview of normal glucose homeostasis -- The metabolic syndrome -- Key features of the metabolic syndrome -- The metabolic syndrome in children and adolescents -- Type 1 and Type 2 diabetes -- Type 1 diabetes -- Latent autoimmune diabetes (LADA) -- Type 2 diabetes -- Type 2 diabetes in Indigenous children and adolescents -- Gestational diabetes -- Maturity onset diabetes of the young (MODY) -- Diagnosing diabetes -- Oral glucose tolerance test (OGTT -- Rationale for (OGIT) -- Preparing the patient for an (OGTT) -- Test protocol -- Screening for diabetes -- Preventing Type 2 diabetes -- Preventing Type 1 diabetes -- Managing diabetes mellitus -- Key points -- The diabetes team -- Aims of management -- Exercise/activity -- Exercise for the person in hospital -- Diabetes education -- Complications of diabetes -- Acute complications -- Long-term complications -- Aim and objectives of nursing care of people with diabetes -- Factors that complicate diabetes management during illness -- Aims and objectives of nursing care -- Aims -- Rationale -- Objectives -- Technology and diabetes management -- A sobering final comment -- References -- Further reading -- 2 Holistic Assessment, Nursing Diagnosis, and Documentation -- Key points -- Rationale -- Holistic nursing -- Care models -- Characteristics of an holistic nursing history -- Nursing history -- Example Health Assessment Chart -- Instruments to measure health status -- Documenting and charting patient care -- Documenting in the health record -- Care plans -- Nursing notes. 327 $aDocumenting metabolic status (`diabetic charts') -- Nursing responsibilities -- Documentation by people with diabetes -- References -- Further reading -- 3 Monitoring Diabetes Mellitus -- Key points -- Rationale -- Introduction -- Monitoring 1: Blood glucose -- Key points -- The role of blood glucose monitoring in the care of diabetes -- Factors that influence blood glucose levels -- Guidelines for the frequency of blood glucose monitoring -- Blood glucose meters -- Continuous glucose monitoring systems -- Continuous glucose monitoring system (CGMS) -- Interpreting different results -- Reasons for inaccurate blood glucose results -- Monitoring blood ketones -- Blood glucose testing checklist -- Monitoring 2: Urine glucose -- Key points -- Indications for urine glucose tests -- Monitoring kidney function -- Methods of screening for microalbuminuria -- Several methods are available and include: -- Monitoring 3: Additional assessment -- Nursing responsibilities -- Blood glucose -- Glycosylated or glycated haemoglobin (HbA1c) -- Fructosamines -- Serum lipids -- C-peptide -- Islet cell antibodies -- Creatinine clearance and urea -- Self-care -- The annual review -- References -- Further reading -- 4 Nutrition, Obesity and Exercise -- Key points -- Rationale -- The importance of good nutrition -- Obesity -- Overview of the pathogenesis of obesity -- The significance of abdominal obesity -- Nutrition, obesity and stress -- Methods of measuring weight -- Crude weight -- Body mass index -- Waist-hip ratio -- Other ways of measuring body fat include -- Managing obesity and diabetes -- Malnutrition and under-nutrition -- Dietary management: diabetes -- Method of screening for dietary characteristics and problems -- Nutritional status -- Dietary characteristics -- Screening tools -- Principles of dietary management for people with diabetes. 327 $aGoals of Dietary Management -- Dietary management: obesity -- Bariatric surgery -- Complementary weight loss programmes -- Factors associated with making dietary changes -- Nursing responsibilities -- 'Sugar-free' foods -- Alternative sweeteners -- Food additives -- Alcohol -- Exercise/activity -- References -- Further reading -- 5 Medicines Management -- Key points -- Introduction -- Quality Use of Medicines (QUM) -- Quality Use of Medicines and Diabetes -- Oral Glucose-Lowering Medicines (GLM) -- Biguanides -- Practice points -- Possible side effects -- Sulphonylureas -- Possible side effects -- Meglitinides -- Thiazolidinediones -- Side effects -- Alpha-glucosidase inhibitors -- The incretin hormones -- Side effects -- New medicines for type 2 diabetes -- Sodium-glucose cotransporter-2 (SGLT2) inhibitors -- Medicine interactions -- Combining GLMs and insulin -- When should insulin be initiated in Type 2 diabetes? -- Barriers to insulin therapy -- Some strategies to overcome the barriers -- Insulin therapy -- Overview of insulin action -- Objectives of insulin therapy -- Types of insulin available -- Rapid-acting insulin -- Short-acting insulin -- Intermediate-acting insulin -- Long-acting insulin -- Ultra-long acting insulin -- Biphasic insulins -- Storing insulin -- Injection sites and administration -- How to inject -- Mixing short- and intermediate-acting insulins -- General points -- Commonly used insulin regimens -- Daily injection -- BD regimens -- Basal bolus regimen -- Interpreting morning hyperglycaemia -- Continuous subcutaneous insulin infusion (CSII) -- Continuous blood glucose sensors -- Subcutaneous insulin sliding scales and top-up regimes -- Top-up or stat doses of insulin -- Intravenous insulin infusions -- Preparing the insulin solution to be infused -- Uses of insulin infusions -- General use (during surgical procedures). 327 $aSpecial needs -- Risks associated with insulin infusions -- Mistakes associated with insulin infusions -- Insulin allergy -- Transplants -- Stabilising diabetes -- Rationale -- Stabilising diabetes in hospital -- Nursing responsibilities -- Community and outpatient stabilisation -- Objectives of outpatient stabilisation onto insulin -- Short-term objectives: -- Long-term objectives -- Rationale for choosing community/outpatient stabilisation -- Patient criteria -- The process of stabilisation -- Lipid-lowering agents -- Side effects -- Monitoring lipid medicines -- Antihypertensive agents -- Antiplatelet agents -- Medication safety, adherence and medication self-management -- Enhancing medication self-care -- Strategies that can be used to monitor medicine adherence -- Example protocol for outpatient stabilisation onto insulin -- References -- 6 Hypoglycaemia -- Key points -- Rationale -- Introduction -- The counter-regulatory response -- Definition of hypoglycaemia -- Recognising hypoglycaemia -- Counter-regulatory hormonal response to hypoglycaemia -- Causes of hypoglycaemia -- Preventing and managing hypoglycaemia -- Hypoglycaemic unawareness -- Prevalence of hypoglycaemic unawareness -- Nocturnal hypoglycaemia -- Indicators of nocturnal hypoglycaemia -- Managing nocturnal hypoglycaemia -- Relative hypoglycaemia -- Medicine interactions -- Objectives of care -- Treatment -- Mild hypoglycaemia -- Severe hypoglycaemia with impaired conscious state -- Prolonged hypoglycaemia -- Patients most at risk of hypoglycaemia -- Psychological effects of hypoglycaemia -- Consequences of hypoglycaemia -- Guidelines for administering glucagon -- Indication -- Instructions for use -- Dosage -- Adverse reactions -- References -- 7 Hyperglycaemia, Acute Illness, Diabetic Ketoacidosis (DKA), Hyperosmolar Hyperglycaemic States (HHS), and Lactic Acidosis -- Key points. 327 $aRationale -- Prevention: proactively managing intercurrent illness -- Self-care during illness -- Hyperglycaemia -- Diabetic ketoacidosis (DKA) -- Late signs of severe DKA -- Differential diagnosis -- Assessment -- Aims of treatment of DKA -- Objectives of nursing care -- Preparing the unit to receive the patient -- Nursing care/observations -- Initial patient care -- Nursing observations (1-2 hourly) -- Subsequent care -- Brittle diabetes and hyperglycaemia -- Complications that can occur as a result of DKA -- Euglycaemic DKA -- Hyperosmolar Hyperglycaemic States -- Presenting signs and symptoms -- Lactic acidosis -- Signs and symptoms -- Lactic acidosis associated with Metformin -- Management -- References -- 8 Long-Term Complications of Diabetes -- Key points -- Introduction -- Pathophysiology of diabetes complications -- Cardiovascular Disease and Diabetes -- Key points -- Rationale -- Medicines and cardiovascular disease -- Complementary medicines (CAM) -- Other management considerations -- Mental health and cardiovascular disease -- Objectives of care in hospital -- Nursing responsibilities -- Medical tests/procedures (see Chapter 9) -- Rehabilitation -- Modifying risk factors associated with the development of cardiac disease -- Telephone coaching -- Cerebrovascular disease -- Signs and symptoms -- Management -- Diabetes and Eye Disease -- Key points -- Rationale -- Introduction -- Risk factors for retinopathy -- Eye problems associated with diabetes -- Resources for people with visual impairment -- Aids for people with low vision -- Nursing care of visually impaired patients -- Aims of care -- People confined to bed -- People who are mobile -- Meal times -- Diabetes and Renal Disease -- Key points -- Introduction -- Stages of chronic kidney disease -- Risk factors for renal disease -- Renal failure -- Renal disease and anaemia. 327 $aDiet and renal disease. 330 $aCare of People with Diabetes is an essential guide to the care and management of people with diabetes mellitus, with particular emphasis on the acute care setting. Written by an experienced clinical nurse specialist with extensive knowledge of evidence-based diabetes care, this fully updated fourth edition serves as an essential companion to clinical practice for nurses and healthcare professionals. People with diabetes experience a high symptom and self-care burden associated with managing their condition, and require appropriate support, advice and regular monitoring. Similarly, health professionals need to maintain and keep up-to-date with an ever-increasing body of knowledge in order to help people with diabetes incorporate new research into their self-care. Care of People with Diabetes provides an extensive overview of the knowledge base all health professionals require to work effectively with people with diabetes. Special features: Comprehensive clinical manual on an ever-more prevalent condition, written to meet the needs of nurses and healthcare professionals Includes new material on evaluating education programmes, cystic fibrosis-related diabetes, diabetes and sleep apnoea, and end-of-life care Provides key evidence for best practice Includes protocols for consistent care and improving patient outcomes. 606 $aDiabetes Mellitus - nursing 608 $aElectronic books. 615 0$aDiabetes Mellitus - nursing. 676 $a616.4/620231 700 $aDunning$b Trisha$0867094 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910823099403321 996 $aCare of people with diabetes$92126812 997 $aUNINA