LEADER 00998nam0-22003251i-450- 001 990000516030403321 005 20070905124010.0 010 $a3-540-54813-0 035 $a000051603 035 $aFED01000051603 035 $a(Aleph)000051603FED01 035 $a000051603 100 $a20020821d1992----km-y0itay50------ba 101 0 $aeng 105 $aa-------001yy 200 1 $aOrdinary differential equations$fVladimir I. Arnol'd 210 $aBerlin ; Heidelberg ; New York$cSpringer-Verlag$dc1992 215 $a334 p.$cill.$d24 cm 225 1 $aSpringer textbook 300 $aSul front.: Trnslated from the Russian by Roger Cooke 610 0 $aEquazioni differenziali 676 $a515'.352 700 1$aArnol'd,$bVladimir Igorevic$f<1937-2010>$022210 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000516030403321 952 $a10 D III 673$bdis 2984$fDINEL 959 $aDINEL 996 $aObyknovennye differentsialnye uravneniya$927524 997 $aUNINA LEADER 05440nam 22006974a 450 001 9910830389103321 005 20170815120509.0 010 $a1-280-40909-6 010 $a9786610409099 010 $a0-470-36036-4 010 $a0-471-73934-0 010 $a0-471-73933-2 035 $a(CKB)1000000000355493 035 $a(EBL)255368 035 $a(OCoLC)304135693 035 $a(SSID)ssj0000200618 035 $a(PQKBManifestationID)11203208 035 $a(PQKBTitleCode)TC0000200618 035 $a(PQKBWorkID)10220744 035 $a(PQKB)10769368 035 $a(MiAaPQ)EBC255368 035 $a(PPN)24326576X 035 $a(EXLCZ)991000000000355493 100 $a20060119d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMedicinal chemistry of bioactive natural products$b[electronic resource] /$fedited by Xiao-Tian Liang, Wei-Shuo Fang 210 $aHoboken, N.J. $cWiley-Interscience/John Wiley$dc2006 215 $a1 online resource (482 p.) 300 $aDescription based upon print version of record. 311 $a0-471-66007-8 320 $aIncludes bibliographical references and index. 327 $aMEDICINAL CHEMISTRY OF BIOACTIVE NATURAL PRODUCTS; CONTENTS; Preface; Contributors; 1 The Chemistry and Biology of Epothilones-Lead Structures for the Discovery of Improved Microtubule Inhibitors; 1.1. Introduction; 1.2. Biological Effects of Epo B; 1.2.1 In Vitro Activity; 1.2.2 In Vivo Antitumor Activity; 1.3. Epothilone Analogs and SAR Studies; 1.3.1 Lactam-Based Analogs; 1.3.2 Modifications in the C9-C11 Region; 1.3.3 Modifications of the Epoxide Moiety; 1.3.4 C-26-Modified Analogs; 1.3.5 Side-Chain Modifications; 1.3.6 Aza-Epothilones 327 $a1.4. Pharmacophore Modeling and Conformational Studies1.5. Epothilone Analogs in Clinical Development; 1.6. Conclusions; Acknowledgments; References; 2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives; 2.1. Introduction; 2.2. Classification of Glycopeptide Antibiotics; 2.3. Mode of Action; 2.4. Glycopeptide Resistance; 2.5. Biosynthesis; 2.6. Total Synthesis; 2.7. Glycopeptides as Chiral Selectors in Chromatography and Capillary Electrophoresis; 2.8. Structural Modifications of Glycopeptide Antibiotics and Structure Activity Relationship (SAR) Studies 327 $a2.8.1 Modifications of Glycopeptide Antibiotics2.8.2 Rational Concepts for the Design of Novel Glycopeptides; 2.8.3 Conclusions; Acknowledgment; References; 3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs; 3.1. Discovery and Research and Development of Taxol; 3.2. Paclitaxel Analogs Active Against Normal Tumor Cells; 3.2.1 C-13 Side Chain; 3.2.2 A Ring and Its Substitutions; 3.2.3 B Ring and Its Substitutions; 3.2.4 C Ring and Its Substitutions; 3.2.5 D Ring; 3.2.6 Macrocyclic Analogs; 3.2.7 Miscellaneous 327 $a3.3. Exploration on Mechanism of Paclitaxel Related to Tubulin Binding and Quest for Its Pharmacophore3.3.1 Biochemical Mechanism of Paclitaxel Related to Tubulin Binding; 3.3.2 Identification of Bioactive Conformations and Quest for a Pharmacophore for Paclitaxel; 3.4. Natural and Semisynthetic Taxoids Overcoming Multidrug Resistance (MDR); 3.4.1 Structure-Modified Taxoids With Better Activity Toward MDR Tumors; 3.4.2 Nonpaclitaxel-Type Taxoids With MDR Reversal Activities; 3.4.3 Factors Contributing to the Resistance to Paclitaxel 327 $a3.5 Design, Synthesis and Pharmacological Activity of Prodrugs of Paclitaxel3.5.1 Prodrugs Prepared to Improve Water Solubility; 3.5.2 Prodrugs Designed for Enhancing Specificity; 3.6 Other Biological Actions of Paclitaxel; 3.7 New Antimicrotubule Molecules Mimicking Action of Paclitaxel; 3.8 Conclusion; Acknowledgments; References; 4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer's Disease; 4.1 Introduction; 4.1.1 Powerful AChEI Originated From Traditional Chinese Medicine; 4.1.2 Alzheimer's Disease; 4.2. Profiles of HA; 4.2.1 Discovery of HA 327 $a4.2.2 Physical Appearance of HA 330 $aCurrent discoveries and research into bioactive natural productsMedicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current rese 606 $aMateria medica, Vegetable 606 $aPharmaceutical chemistry 606 $aNatural products 606 $aBioactive compounds 615 0$aMateria medica, Vegetable. 615 0$aPharmaceutical chemistry. 615 0$aNatural products. 615 0$aBioactive compounds. 676 $a615.321 676 $a615/.321 701 $aLiang$b Xiaotian$01680945 701 $aFang$b Wei-Shuo$01680946 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830389103321 996 $aMedicinal chemistry of bioactive natural products$94050011 997 $aUNINA