LEADER 05043nam 2200601 a 450 001 9910830291503321 005 20230725023535.0 010 $a1-282-69064-7 010 $a9786612690648 010 $a3-527-63027-9 010 $a3-527-63028-7 035 $a(CKB)2670000000019016 035 $a(EBL)530454 035 $a(SSID)ssj0000429272 035 $a(PQKBManifestationID)11274771 035 $a(PQKBTitleCode)TC0000429272 035 $a(PQKBWorkID)10430187 035 $a(PQKB)10645653 035 $a(MiAaPQ)EBC530454 035 $a(OCoLC)654787206 035 $a(EXLCZ)992670000000019016 100 $a20100614d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSystems biology in psychiatric research$b[electronic resource] $efrom high-throughput data to mathematical modeling /$fedited by Felix Tretter ... [et al.] 210 $aWeinheim $cWiley-VCH$d2010 215 $a1 online resource (380 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32503-4 320 $aIncludes bibliographical references and index. 327 $aSystems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling; Foreword; Contents; Preface; List of Contributors; Part One: Introduction; 1 Philosophical Aspects of Neuropsychiatry; 1.1 Development of Research Paradigms and Strategies in Psychiatry; 1.2 The Mind-Body Problem - Philosophy of Mind; 1.2.1 Monism and Dualism; 1.2.2 Correlation; 1.2.3 Identity Theory and its Problems; 1.2.4 Causation; 1.2.5 Supervenience; 1.3 The Conditions of Scientific Knowledge - Philosophy of Science; 1.4 Experimental Research - From Observation to Theory 327 $a1.4.1 Hypotheses and Theory1.4.2 The ""Epistemic Cycle""; 1.4.3 Top-Down Analysis - Reductionism?; 1.4.4 Bottom-Up Explanations - Holism?; 1.5 Theoretical (Neuro)psychiatry; 1.6 Systems Thinking; 1.7 Perspectives - Towards a ""Neurophilosophy""; References; 2 Neuropsychiatry - Subject, Concepts, Methods, and Computational Models; 2.1 Introduction; 2.2 Psychiatric Fundamentals of Neuropsychiatry; 2.2.1 General Psychiatry; 2.2.2 Psychopathology; 2.2.2.1 Quantitative Psychopathology; 2.2.2.2 Theoretical Psychopathology; 2.2.3 Psychiatric Diagnoses; 2.2.3.1 Diagnostic Criteria 327 $a2.2.4 Theoretical Psychiatry2.2.4.1 ""Computational Neuropsychiatry""; 2.2.4.2 ""Systems Neuropsychiatry""; 2.3 Neurobiological Fundamentals of Neuropsychiatry; 2.3.1 Basic Findings of (Neuro)biological Psychiatry; 2.3.1.1 Neuropsychopathology; 2.3.1.2 Neurobiological Methods; 2.3.1.3 Experimental Paradigms; 2.3.1.4 Structure and Function of the Brain; 2.3.1.5 Global Circuits and their Connectivities; 2.3.1.6 Local Networks of Neurons; 2.3.1.7 Prefrontal Network in Schizophrenia; 2.3.2 Neuron; 2.3.2.1 Electrical Signaling of the Neuron; 2.3.3 Synapse; 2.3.3.1 Receptors 327 $a2.3.4 The Cell as a System of Interacting Molecules2.3.4.1 Intracellular Signal Cascades - From Receptor to Genome; 2.3.4.2 Modeling Signal Transduction Networks Relevant in Schizophrenia; 2.3.4.3 Genomics and Proteomics; 2.3.4.4 Gene Regulation - Circular Signaling Pathways; 2.3.4.5 Systems Biology of the Neuron; 2.3.5 The Brain as a Neurochemical Oscillator; 2.3.5.1 Neurochemical Interaction Matrix; 2.3.5.2 ""Neurochemical Mobile""; 2.4 Conclusions and Perspectives; References; 3 Introduction to Systems Biology; 3.1 Introduction; 3.1.1 What is Systems Biology?; 3.1.2 Purpose of Modeling 327 $a3.1.3 Levels of Modeling3.2 Data Analysis; 3.2.1 Types of Data; 3.2.1.1 Purification; 3.2.1.2 Detection; 3.2.1.3 Large-Scale Analyses; 3.2.1.4 Identification of Components; 3.2.2 Working with Data; 3.2.2.1 Different Clustering Approaches; 3.2.2.2 Principal Component Analysis; 3.3 ODE Modeling; 3.3.1 Differential Equations; 3.3.2 Stoichiometric Matrix; 3.3.3 Reaction Kinetics; 3.3.4 Steady States; 3.3.5 Metabolic Control Analysis; 3.3.6 Simulating Models; 3.3.7 Parameter Estimation; 3.4 Results Gained from Systems Biology; 3.4.1 Just-in-Time Transcription 327 $a3.5 Standard Formats, Databases, and Tools 330 $aThis first book to provide a comprehensive overview of the recent progress made in this break-through approach includes expert contributions from a variety of disciplines. Particular focus is placed on high-throughput methods and the analysis of data thus obtained, as well as their use in silico experiments so as to gain an insight into the complex biological processes in neuronal systems.A must-have for everyone working in psychiatric research. 606 $aPsychiatry$xResearch 615 0$aPsychiatry$xResearch. 676 $a616.89 676 $a616.890072 686 $a44.91$2bcl 701 $aTretter$b Felix$01613906 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830291503321 996 $aSystems biology in psychiatric research$93943448 997 $aUNINA