LEADER 05505nam 22008413u 450 001 9910830200703321 005 20210114201504.0 010 $a1-282-37219-X 010 $a9786612372193 010 $a3-527-62022-2 010 $a3-527-62029-X 035 $a(CKB)1000000000376041 035 $a(EBL)481469 035 $a(SSID)ssj0000398390 035 $a(PQKBManifestationID)11295299 035 $a(PQKBTitleCode)TC0000398390 035 $a(PQKBWorkID)10374387 035 $a(PQKB)11417206 035 $a(MiAaPQ)EBC481469 035 $a(OCoLC)212142028 035 $a(EXLCZ)991000000000376041 100 $a20131104d2008|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aProtein Degradation$b[electronic resource] $eCell Biology of the Ubiquitin-Proteasome System 210 $aHoboken $cWiley$d2008 215 $a1 online resource (254 p.) 225 1 $aProtein Degradation ;$vv.7 300 $aDescription based upon print version of record. 311 $a3-527-31435-0 327 $aProtein Degradation; Contents; Preface; List of Contributors; 1 Ubiquitin: A New Player in the Peroxisome Field; 1.1 Introduction; 1.2 Matrix Protein Import into Peroxisomes is Mediated by Cycling Receptors; 1.3 Pex5p is Monoubiquitinated in Wild-type Cells, but Polyubiquitinated in Late-acting pex Mutants; 1.4 Ubiquitination of Pex18p; 1.5 Role for the RING Finger and AAA Peroxins in Pex5p Ubiquitination and Recycling; 1.6 Pex5p Monoubiquitination: A Role in Receptor Recycling; 1.7 Conclusions/Future Prospects; Acknowledgements; References 327 $a2 The Ubiquitin Proteasome System and Muscle Development2.1 Introduction; 2.2 Muscle Histology; 2.3 UPS and Developing Muscle; 2.3.1 Ubiquitin-dependent Degradation of MyoD; 2.3.2 Degradation of MyoD by SCF(MAFbx); 2.3.3 Other Muscle Regulatory Factors; 2.4 UPS and Organizing Muscle; 2.4.1 Ozz-E3-dependent ?-Catenin Regulation in the Muscle; 2.4.2 Regulation of Myosin Assembly by CHN-1 and UFD-2; 2.5 UPS and Muscle Destruction or Degeneration; 2.5.1 N-end Rule and Muscle Atrophy; 2.5.2 MuRFs, E3 Enzymes in Atrophying Muscles; 2.5.3 Atrogin-1/MAFbx Function in Muscle Atrophy 327 $a2.5.4 Activation of Muscle-atrophy Pathways2.6 Concluding Remarks; References; 3 The COP9 Signalosome: Structural and Biochemical Conservation and Its Roles in the Regulation of Plant Development; 3.1 Introduction; 3.2 The Plant COP9 Signalosome; 3.3 CSN Involvement in the Ubiquitin-Proteasome Pathway; 3.4 Plant CSN Biochemical Activities; 3.4.1 Deneddylation; 3.4.2 Subcellular Partitioning; 3.5 CSN Functions in Plant Development; 3.5.1 Floral Development; 3.5.2 Responses to Plant Hormones; 3.5.3 Disease Resistance; 3.5.4 Photomorphogenesis; 3.6 Conclusions; References 327 $a4 Ubiquitin and Protein Sorting to the Lysosome4.1 Introduction; 4.2 Identification of Ubiquitin as an Endosomal Sorting Signal; 4.3 Ubiquitin-mediated Sorting at the Endosome: The MVB Sorting Machinery; 4.3.1 Endosome-associated Ubiquitin Interacting Domains: Structure and Function; 4.3.2 The Hrs-STAM Complex and the Endosomal Clathrin Coat; 4.3.3 GGA and Tom1: Alternative Sorting Adapters?; 4.3.4 The ESCRT Machinery; 4.3.5 Vps4-SKD1; 4.4 Ubiquitin Ligases and Endosomal Sorting; 4.4.1 Nedd4 Family; 4.4.2 c-Cbl; 4.5 Endosomal DUBs; 4.5.1 Ubp1 and Ubp2; 4.5.2 Doa4; 4.5.3 UBPY; 4.5.4 AMSH 327 $a4.6 Polyubiquitin Linkages and Endocytosis4.6.1 Proteasome Involvement in Endocytic Sorting; 4.6.2 K63-linked Ubiquitin; 4.7 Future Directions; Acknowledgements; References; 5 ISG15-dependent Regulation; 5.1 Introduction and Overview; 5.2 The Discovery of ISG15; 5.3 Structure and Properties of the ISG15 Protein; 5.4 The ISG15 Conjugation Pathway; 5.4.1 Activation of ISG15 by UbE1L; 5.4.2 UbcH8 is an ISG15-specific Conjugating Enzyme; 5.4.3 Candidate ISG15-specific Ligases; 5.5 Regulation of Intracellular ISG15 Pools; 5.6 Functional Roles for ISG15; 5.6.1 ISG15 as an Extracellular Cytokine 327 $a5.6.2 Role of ISG15 in the Antiviral Response 330 $aThe third of four volumes discusses the role of ubiquitin-mediated protein breakdown in cellular regulation and physiology. Required reading for molecular biologists, cell biologists and physiologists with an interest in the topic. 410 0$aProtein Degradation 606 $aCell Physiology 606 $aProteins - Metabolism 606 $aProteins - metabolism 606 $aProteins --Metabolism 606 $aUbiquitin 606 $aUbiquitin - physiology 606 $aUbiquitin 606 $aAnimal Biochemistry$2HILCC 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 615 4$aCell Physiology. 615 4$aProteins - Metabolism. 615 4$aProteins - metabolism. 615 4$aProteins --Metabolism. 615 4$aUbiquitin. 615 4$aUbiquitin - physiology. 615 4$aUbiquitin. 615 7$aAnimal Biochemistry 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 676 $a572.76 676 $a612.3/98 700 $aMayer$b R. John$0723858 701 $aCiechanover$b Aaron J$01663486 701 $aRechsteiner$b Martin$01663487 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910830200703321 996 $aProtein Degradation$94082543 997 $aUNINA