LEADER 05459nam 2200673Ia 450 001 9910830161903321 005 20230617035347.0 010 $a1-280-51948-7 010 $a9786610519484 010 $a3-527-60375-1 010 $a3-527-60384-0 035 $a(CKB)1000000000376379 035 $a(EBL)481511 035 $a(OCoLC)69243366 035 $a(SSID)ssj0000211433 035 $a(PQKBManifestationID)11201930 035 $a(PQKBTitleCode)TC0000211433 035 $a(PQKBWorkID)10293010 035 $a(PQKB)11149194 035 $a(MiAaPQ)EBC481511 035 $a(EXLCZ)991000000000376379 100 $a20040716d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNitric oxide donors$b[electronic resource] $efor pharmaceutical and biological applications /$fedited by Peng George Wang, Tingwei Bill Cai, Naoyuki Taniguchi 210 $aWeinheim ;$a[Great Britain] $cWiley-VCH$dc2005 215 $a1 online resource (414 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31015-0 320 $aIncludes bibliographical references and index. 327 $aNitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer 327 $a1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates 327 $a2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines 327 $a3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates 327 $a3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs 327 $a4.2.1 Regulation of Blood Flow by HbSNO 330 $aNitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes.In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances. 606 $aNitric oxide 606 $aNitric oxide$xPhysiological effect 606 $aDrugs$xDesign 606 $aPharmaceutical chemistry 615 0$aNitric oxide. 615 0$aNitric oxide$xPhysiological effect. 615 0$aDrugs$xDesign. 615 0$aPharmaceutical chemistry. 676 $a572.54 701 $aWang$b Peng George$0738023 701 $aCai$b Tingwai Bill$01611266 701 $aTaniguchi$b Naoyuki$f1942-$01611267 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830161903321 996 $aNitric oxide donors$93939433 997 $aUNINA