LEADER 03404nam 2200625Ia 450 001 9910830148803321 005 20230421044557.0 010 $a1-282-34788-8 010 $a9786612347887 010 $a0-470-51455-8 010 $a0-470-51456-6 035 $a(CKB)1000000000377137 035 $a(EBL)470550 035 $a(OCoLC)609849502 035 $a(SSID)ssj0000304156 035 $a(PQKBManifestationID)11229498 035 $a(PQKBTitleCode)TC0000304156 035 $a(PQKBWorkID)10277867 035 $a(PQKB)11746553 035 $a(MiAaPQ)EBC470550 035 $a(EXLCZ)991000000000377137 100 $a19930831d1994 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNeural tube defects$b[electronic resource] /$f[editors, Gregory Bock and Joan Marsh] 210 $aChichester ;$aNew York $cWiley$d1994 215 $a1 online resource (312 p.) 225 1 $aCiba Foundation symposium ;$v181 300 $a"Symposium on Neural Tube Defects held at the Ciba Foundation, London, 18-20 May 1993"--Contents p.v. 311 $a0-471-94172-7 320 $aIncludes bibliographical references and index. 327 $aNEURAL TUBE DEFECTS; Contents; Participants; Introduction; Normal neurulation in amphibians; Formation and patterning of the avian neuraxis: one dozen hypotheses; Normal neurulation in mammals; Neurulation in the normal human embryo; Molecular genetics of neurulation; Pax genes and neural tube defects in the mouse; Genetic models of mammalian neural tube defects; Valproic acid-induced neural tube defects; Vitamins, folic acid and the cause and prevention of neural tube defects; Folic acid metabolism and mechanisms of neural tube defects 327 $aFolic acid and neural tube defects: the current evidence and implications for preventionPrevention of folic acid-preventable spina bifida and anencephaly; Spina bifida: anticonvulsants and other maternal influences; General discussion; Screening for neural tube defects; Meningomyelocele: management in utero and post natum; Final discussion; Index of contributors; Subject index 330 $aNeural tube defects are the second most common cause of perinatal death from birth defects in the United Kingdom. In this important book, leading scientists evaluate the latest evidence on the causative factors--both genetic and environmental--of these major human congenital malformations. They also discuss prospects for early detection by prenatal screening and for treatment both before and after birth. The extensive coverage encompasses such topics as: formation and patterning of the avian neuraxis, neurulation in mammals and the normal human embryo, folic acid and more. 410 0$aCiba Foundation symposium ;$v181. 606 $aNeural tube$xAbnormalities$vCongresses 606 $aNervous system$xAbnormalities$vCongresses 615 0$aNeural tube$xAbnormalities 615 0$aNervous system$xAbnormalities 676 $a612.6 676 $a612.64018 676 $a616.8 701 $aBock$b Gregory$0322650 701 $aMarsh$b Joan$091633 712 12$aSymposium on Neural Tube Defects$f(1993 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830148803321 996 $aNeural tube defects$94079446 997 $aUNINA