LEADER 05328nam 2200745Ia 450 001 9910830142903321 005 20170815154012.0 010 $a1-282-30164-0 010 $a9786612301643 010 $a0-470-18688-7 010 $a0-470-18836-7 035 $a(CKB)1000000000376544 035 $a(EBL)469645 035 $a(OCoLC)814416086 035 $a(SSID)ssj0000388137 035 $a(PQKBManifestationID)11284268 035 $a(PQKBTitleCode)TC0000388137 035 $a(PQKBWorkID)10411423 035 $a(PQKB)10636340 035 $a(SSID)ssj0000360399 035 $a(PQKBManifestationID)11253385 035 $a(PQKBTitleCode)TC0000360399 035 $a(PQKBWorkID)10326196 035 $a(PQKB)10906194 035 $a(MiAaPQ)EBC469645 035 $a(PPN)241443156 035 $a(EXLCZ)991000000000376544 100 $a20070725d1971 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFused pyrimidines$hPart two$b[electronic resource] /$fedited by D. J. Brown 205 $a99th ed. 210 $aNew York $cWiley-Interscience$d1971 215 $a1 online resource (684 p.) 225 1 $aChemistry of heterocyclic compounds ;$vv. 24, pt. 2 300 $aDescription based upon print version of record. 311 $a0-471-38205-1 320 $aIncludes bibliographical references and index. 327 $aFUSED PYRIMIDINES: PURINES; Contents; Tables; I. Introduction to the Purines; 1. History; TABLE 1. Trivial Names of Purines; 2. Nomenclature and Notation; 3. The Basis of Purine Chemistry; A. The Electrophilic Character of the 2-, 6- and 8-Carbon Atoms; B. The Nucleophilic Character of the 8-Carbon Atom; C. Tautomeric Groups; 4. General Summary of Purine Chemistry; A. Electrophilic Substitution; (a) Nitration; (b) Diazo Coupling; (c) Halogenation; (d) Alkylation; B. Nucleophilic Substitution; (a) Halogen Replacement by Amino Groups; (b) Halogen Replacement by Methoxy and Other Alkoxy Groups 327 $a(c) Halogen Replacement by Oxo Group(d) Halogen Replacement by Alkylthio Groups; (e) Halogen Replacement by Thio Group; (f) Halogen Replacement by Thiocyanato and Cyano Groups; (g) Halogen Replacement by Sulpho Groups; (h) Replacement of Methoxy, Methylthio, and Methylsulphonyl Groups; C. Group Interconversion; (a) Interchange of Halogen Atoms; (b) Oxo- to Aminopurines; (c) Oxo- to Chloropurines; (d) Oxo- to Thiopurines; (e) Thio- (and Methylthio-) to Oxopurines; (f) Thio- (and Methylthio-) to Halogenopurines; (g) Thio- to Aminopurines; (h) Interchange of Amino Groups 327 $a(i) Amino- to Oxopurines(j) Amino- to Halogenopurines; D. Addition Reactions; (a) The Michael Reaction; (b) Quaternisation; (c) Formation of N-Oxides; (d) Addition of Water and Alcohols; E. Modification of Substituents; (a) Amino Groups; (b) Oxo Groups; (c) Thio Groups; (d) Methyl Groups; F. Reductive Reactions; (a) Nuclear Reduction; (b) Removal of Groups; (c) Reductive Modification of Groups; G. Oxidative Reactions; (a) Chemical Oxidation; (b) Free Radical Attack; (c) Enzymic Oxidation; 5. Physical Properties of Purines; A. Electronic Considerations; B. Ionisation Constants 327 $aC. Crystal StructureD. Dipole Moments; E. Polarography; F. Solubility and Melting Point; G. Spectra; Chapter II. Syntheses from Pyrimidines; 1. Use of 4,5-Diaminopyrimidines (The Traube Synthesis); A. History and General Application; B. Cyclisation with Formic Acid; C. Cyclisation with Dithioformic Acid; D. Cyclisation with Other Carboxylic Acids; E. Cyclisation with Acid Anhydride; F. Cyclisation with Acid Chlorides; G. Cyclisation with Orthoesters and Diethoxymethyl Acetate 327 $aTABLE 2. Cyclisation of 4,5-Diamino-6-dimethylamino-2-methylthiopyrimidine to 6-dimethylamino-2-methylthiopurine with OrthoestersH. Cyclisation with Formamide; I. Cyclisation with Other Amides; J. Cyclisation with NN-Dialkylamides and Phosphoryl Chloride; K. Cyclisation with Amidines; L. Cyclisation with Guanidines; M. Cyclisation with Urea; N. Cyclisation with Thiourea; O. Cyclisation with Cyanates, Isocyanates, and Derivatives; P. Cyclisation with lsothiocyanates; Q. Cyclisation with Carbon Dioxide; R. Cyclisation with Carbon Disulphide; S. Cyclisation with Phosgene 327 $aT. Cyclisation with Thiophosgene 330 $aChemistry of Heterocyclic Compounds publishes articles, letters to the Editor, reviews, and minireviews on the synthesis, structure, reactivity, and biological activity of heterocyclic compounds including natural products. The journal covers investigations in heterocyclic chemistry taking place in scientific centers of all over the world, including extensively the scientific institutions in Russia, Ukraine, Latvia, Lithuania and Belarus. 410 0$aChemistry of heterocyclic compounds ;$vv. 24, pt. 2. 606 $aPyrimidines 606 $aChemistry 615 0$aPyrimidines. 615 0$aChemistry. 676 $a547.593 676 $a547/.59/05 676 $a547/.596 700 $aLister$b John H$g(John Henry)$0958395 701 $aBrown$b D. J$0383088 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830142903321 996 $aFused pyrimidines$93984779 997 $aUNINA