LEADER 05107nam 2200637Ia 450 001 9910830140403321 005 20230617021316.0 010 $a1-280-56086-X 010 $a9786610560868 010 $a3-527-60605-X 010 $a3-527-60236-4 035 $a(CKB)1000000000019292 035 $a(EBL)481763 035 $a(SSID)ssj0000111593 035 $a(PQKBManifestationID)11137789 035 $a(PQKBTitleCode)TC0000111593 035 $a(PQKBWorkID)10080398 035 $a(PQKB)10442447 035 $a(MiAaPQ)EBC481763 035 $a(OCoLC)85820383 035 $a(EXLCZ)991000000000019292 100 $a20040412d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBiocatalysis$b[electronic resource] /$fA. S. Bommarius, B. R. Riebel 210 $aWeinheim ;$aCambridge $cWiley-VCH$dc2004 215 $a1 online resource (637 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30344-8 320 $aIncludes bibliographical references (p.591-592) and index. 327 $aBiocatalysis; Preface; Acknowledgments; Contents; 1 Introduction to Biocatalysis; 1.1 Overview: The Status of Biocatalysis at the Turn of the 21st Century; 1.1.1 State of Acceptance of Biocatalysis; 1.1.2 Current Advantages and Drawbacks of Biocatalysis; 1.1.2.1 Advantages of Biocatalysts; 1.1.2.2 Drawbacks of Current Biocatalysts; 1.2 Characteristics of Biocatalysis as a Technology; 1.2.1 Contributing Disciplines and Areas of Application; 1.2.2 Characteristics of Biocatalytic Transformations; 1.2.2.1 Comparison of Biocatalysis with other Kinds of Catalysis 327 $a1.2.3 Applications of Biocatalysis in Industry1.2.3.1 Chemical Industry of the Future: Environmentally Benign Manufacturing, Green Chemistry, Sustainable Development in the Future; 1.2.3.2 Enantiomerically Pure Drugs or Advanced Pharmaceutical Intermediates (APIs); 1.3 Current Penetration of Biocatalysis; 1.3.1 The Past: Historical Digest of Enzyme Catalysis; 1.3.2 The Present: Status of Biocatalytic Processes; 1.4 The Breadth of Biocatalysis; 1.4.1 Nomenclature of Enzymes; 1.4.2 Biocatalysis and Organic Chemistry, or "Do we Need to Forget our Organic Chemistry?" 327 $a2 Characterization of a (Bio-)catalyst2.1 Characterization of Enzyme Catalysis; 2.1.1 Basis of the Activity of Enzymes: What is Enzyme Catalysis?; 2.1.1.1 Enzyme Reaction in a Reaction Coordinate Diagram; 2.1.2 Development of Enzyme Kinetics from Binding and Catalysis; 2.2 Sources and Reasons for the Activity of Enzymes as Catalysts; 2.2.1 Chronology of the Most Important Theories of Enzyme Activity; 2.2.2 Origin of Enzymatic Activity: Derivation of the Kurz Equation; 2.2.3 Consequences of the Kurz Equation; 2.2.4 Efficiency of Enzyme Catalysis: Beyond Pauling's Postulate 327 $a2.3 Performance Criteria for Catalysts, Processes, and Process Routes2.3.1 Basic Performance Criteria for a Catalyst: Activity, Selectivity and Stability of Enzymes; 2.3.1.1 Activity; 2.3.1.2 Selectivity; 2.3.1.3 Stability; 2.3.2 Performance Criteria for the Process; 2.3.2.1 Product Yield; 2.3.2.2 (Bio)catalyst Productivity; 2.3.2.3 (Bio)catalyst Stability; 2.3.2.4 Reactor Productivity; 2.3.3 Links between Enzyme Reaction Performance Parameters; 2.3.3.1 Rate Acceleration; 2.3.3.2 Ratio between Catalytic Constant k(cat) and Deactivation Rate Constant k(d) 327 $a2.3.3.3 Relationship between Deactivation Rate Constant k(d) and Total Turnover Number TTN2.3.4 Performance Criteria for Process Schemes, Atom Economy, and Environmental Quotient; 3 Isolation and Preparation of Microorganisms; 3.1 Introduction; 3.2 Screening of New Enzyme Activities; 3.2.1 Growth Rates in Nature; 3.2.2 Methods in Microbial Ecology; 3.3 Strain Development; 3.3.1 Range of Industrial Products from Microorganisms; 3.3.2 Strain Improvement; 3.4 Extremophiles; 3.4.1 Extremophiles in Industry; 3.5 Rapid Screening of Biocatalysts; 4 Molecular Biology Tools for Biocatalysis 327 $a4.1 Molecular Biology Basics: DNA versus Protein Level 330 $aThe whole range of biocatalysis, from a firm grounding in theoretical concepts to in-depth coverage of practical applications and future perspectives. The book not only covers reactions, products and processes with and from biological catalysts, but also the process of designing and improving such biocatalysts.One unique feature is that the fields of chemistry, biology and bioengineering receive equal attention, thus addressing practitioners and students from all three areas. 606 $aEnzymes$xBiotechnology 606 $aBiosynthesis 606 $aCatalysis 615 0$aEnzymes$xBiotechnology. 615 0$aBiosynthesis. 615 0$aCatalysis. 676 $a660.634 700 $aBommarius$b A. S$g(Andreas Sebastian)$0442347 701 $aRiebel$b B. R$g(Bettina R.)$0442348 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830140403321 996 $aBiocatalysis$985079 997 $aUNINA