LEADER 03613 am 2200853 n 450 001 9910137025303321 005 20160602 010 $a2-7535-4938-9 024 7 $a10.4000/books.pur.34338 035 $a(CKB)3710000000731118 035 $a(FrMaCLE)OB-pur-34338 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/49540 035 $a(PPN)194303659 035 $a(EXLCZ)993710000000731118 100 $a20160622j|||||||| ||| 0 101 0 $afre 135 $auu||||||m|||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHommes, cultures et paysages de l'Antiquité à la période moderne $eMélanges offerts à Jean Peyras /$fIsabelle Pimouguet-Pédarros, Monique Clavel-Levêque, Fatima Ouachour 210 $aRennes $cPresses universitaires de Rennes$d2016 215 $a1 online resource (451 p.) 311 $a2-7535-2143-3 330 $aCet ouvrage rend hommage à Jean Peyras, professeur d'histoire ancienne à l'université de Nantes. Il réunit une vingtaine de contributions sur des sujets divers touchant à l'histoire ancienne, médiévale et moderne. Il couvre de nombreux espaces géographiques : l'Afrique romaine, l'Asie Mineure, l'Étrurie, la Grèce et Rome, sans compter les terres du midi, la Vendée ou encore le Rhin. Les questions qui sont abordées touchent à l'organisation et à la défense des territoires (bornes, arpentage, frontières, fortifications), à l'armée, à l'architecture, à l'urbanisme et au pouvoir, aux rapports ville/campagne ou encore à la construction et à l'évolution des sociétés (peuplement, métissage, acculturations). 606 $aHumanities, Multidisciplinary 606 $aHistory 606 $aJean Peyras 606 $agéographie historique 606 $aaménagement 606 $apaysage 610 $aaménagement 610 $agéographie historique 610 $apaysage 610 $aJean Peyras 615 4$aHumanities, Multidisciplinary 615 4$aHistory 615 4$aJean Peyras 615 4$agéographie historique 615 4$aaménagement 615 4$apaysage 700 $aAounallah$b Samir$01282013 701 $aBehrends$b Okko$0184072 701 $aBen Baaziz$b Sadok$01282014 701 $aBois$b Jean-Pierre$01282015 701 $aBrahmi$b Néjat$01282016 701 $aCapogrossi Colognesi$b Luigi$01282017 701 $aChristol$b Michel$0223421 701 $aClavel-Lévêque$b Monique$0205040 701 $aGonzales$b Antonio$0287412 701 $aGuerber$b Éric$01282018 701 $aGuillaumin$b Jean-yves$0387644 701 $aHermon$b Ella$0242057 701 $aJannot$b Jean-René$0488150 701 $aLévêque$b Laure$01102530 701 $aL?Huillier$b Marie-Claude$01282019 701 $aMaurin$b Louis$0241876 701 $aOuachour$b Fatima$01282020 701 $aPiel$b Thierry$01282021 701 $aPimouguet-Pédarros$b Isabelle$0479106 701 $aPortet$b Pierre$01282022 701 $aReduzzi Merola$b Francesca$01282023 701 $aRizakis$b Athanasios$0298683 701 $aRonin$b Marguerite$01282024 701 $aSantrot$b Jacques$0664434 701 $aTolan$b John$0555371 701 $aPimouguet-Pédarros$b Isabelle$0479106 701 $aClavel-Levêque$b Monique$0205040 701 $aOuachour$b Fatima$01282020 801 0$bFR-FrMaCLE 906 $aBOOK 912 $a9910137025303321 996 $aHommes, cultures et paysages de l'Antiquité à la période moderne$93018643 997 $aUNINA LEADER 05577nam 22006854a 450 001 9910830124003321 005 20210811191717.0 010 $a1-280-26932-4 010 $a9786610269327 010 $a0-470-09265-3 010 $a0-470-01419-9 035 $a(CKB)1000000000018864 035 $a(EBL)210565 035 $a(OCoLC)56748823 035 $a(SSID)ssj0000251404 035 $a(PQKBManifestationID)11200725 035 $a(PQKBTitleCode)TC0000251404 035 $a(PQKBWorkID)10247113 035 $a(PQKB)11768588 035 $a(MiAaPQ)EBC210565 035 $a(PPN)137732007 035 $a(EXLCZ)991000000000018864 100 $a20040426d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aStephens' detection of new adverse drug reactions /$fedited by John Talbot, Patrick Waller 205 $a5th ed. 210 $aChichester ;$aHoboken, NJ $cWiley$dc2004 215 $a1 online resource (763 p.) 300 $aRev. ed. of: Detection of new adverse drug reactions / edited by M.D.B. Stephens, J.C.C. Talbot, and P.A. Routledge. 4th ed. 1998. 311 $a0-470-84552-X 320 $aIncludes bibliographical references and index. 327 $aStephens' Detection of New Adverse Drug Reactions Fifth Edition; Contents; Foreword; Preface; List of Contributors; 1 Introduction; Mercury; Introduction to pharmacovigilance; The history of pharmacovigilance; Under-reporting of adverse drug reactions; Incidence of adverse drug reactions; The financial cost of adverse drug reactions; Preventability of adverse drug reactions; Risk-benefit ratio; The changing risks with new drugs; Expression of risk; The risks we are prepared to take; Definitions; Classification of adverse drug reactions; Adverse reaction profile 327 $aAdverse events in a patient's lifeSymptoms in healthy persons; Adverse reactions to placebo; Infectiousness of adverse drug reactions; Herbal medicines; Some final food for thought; References; Further reading; 2 Adverse Drug Reactions and Interactions: Mechanisms, Risk Factors, Detection, Management and Prevention; Introduction; Classification of adverse drug reactions; Risk factors for type A adverse reactions; Risk factors for type B adverse reactions; Detection of adverse drug reactions; Management of adverse drug reactions; Prevention of adverse drug reactions; Drug interactions 327 $aConclusionsReferences; 3 Toxicology and Adverse Drug Reactions; Introduction; Toxicity testing; Drug development; Data interpretation and risk assessment; Adverse drug reactions detected after authorization; Examples of toxicological investigation of adverse drug reactions; Conclusions; Acknowledgements; References; 4 Clinical Trials: Collection of Safety Data and Establishing the Adverse Drug Reaction Profile; Introduction; Adverse events; Final analysis of data; Inadequate reporting of safety data from clinical trials; Conclusions; Future aspirations; Acknowledgements; References 327 $a5 Clinical Laboratory Safety Data in Drug StudiesIntroduction; Factors that influence interpretation of clinical laboratory data; Sample collection procedure; Analytical variation; Reference ranges; Intra-individual biological variation; Safety testing in drug development; Test selection; Exclusion criteria and 'panic levels'; Harmonization of data from different laboratories; Data analysis and presentation; Conclusion; References; 6 Statistics: Analysis and Presentation of Safety Data; Introduction and background; Analysis and presentation of data from trials 327 $aMeasures that take time into accountStatistical tests utilizing time since start of treatment; Combining data from several trials: meta-analysis; Analysis and presentation of data from observational studies; Use of statistical methods for signal detection with spontaneous reports; Summary and conclusions; Acknowledgements; References; 7 Causality and Correlation in Pharmacovigilance; Introduction and historical background; The notions of necessary and sufficient causes; Factors to be considered in causality assessment; Methods for causality assessment; When to assess causality 327 $aAssessing causality from multiple information sources: the Bradford-Hill criteria 330 $aA key text for all those involved in pharmacovigilance. Detection of new adverse drug reactions is fundamental to the protection of patients from harm that may occur as a result of medication. This book explores the methods used to investigate new adverse drug reactions, discussing all elements from the scientific background and animal toxicology through to worldwide regulatory and ethical issues. Stephens' Detection of New Adverse Drug Reactions provides comprehensive and up-to-date coverage of material fundamentally important to all those active in the field, whether they w 606 $aDrugs$xSide effects 606 $aDrugs$xToxicology 606 $aDrugs$xSide effects$vHandbooks, manuals, etc 615 0$aDrugs$xSide effects. 615 0$aDrugs$xToxicology. 615 0$aDrugs$xSide effects 676 $a615.7042 676 $a615/.7042 701 $aStephens$b M. D. B.$f1930-$01637510 701 $aTalbot$b J. C. C$01637511 701 $aWaller$b Patrick$0521105 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830124003321 996 $aStephens' detection of new adverse drug reactions$93979375 997 $aUNINA