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010   $a1-280-65435-X
010   $a0-470-84630-5
010   $a9786610654352
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035   $a(PQKBTitleCode)TC0000148618
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100   $a20160829d2002      uy              
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt
182   $cc
183   $acr
200 00$aEnzyme systems that metabolise drugs and other xenobiotics
205   $a1st ed.
210 31$a[Place of publication not identified]$cJohn Wiley & Sons$d2002
215   $a1 online resource (578 pages)
300   $aBibliographic Level Mode of Issuance: Monograph
311   $a0-471-89466-4 
311   $a0-470-85198-8 
330   $aThis definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:* enzyme function in the metabolism and bioactivation of xenobiotics* substrate specificity* tissue distribution* species distribution (to include laboratory animals and humans)* hormonal regulation* sex differences* modulation by prior exposure to other chemicals* age-dependent expression* pharmacogenetics and modulation by disease.Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.
606   $aPharmaceutical Preparations
606   $aXenobiotics
606   $aEnzymes
606   $aChemicals and Drugs
606   $aEnzymes and Coenzymes
606   $aPharmacy, Therapeutics, & Pharmacology$2HILCC
606   $aHealth & Biological Sciences$2HILCC
615  2$aPharmaceutical Preparations
615  2$aXenobiotics
615  2$aEnzymes
615  2$aChemicals and Drugs
615  2$aEnzymes and Coenzymes
615  7$aPharmacy, Therapeutics, & Pharmacology
615  7$aHealth & Biological Sciences
676   $a615.7
702   $aIoannides$b Costas
801  0$bPQKB
906   $aBOOK
912   $a9910830113403321
996   $aEnzyme systems that metabolise drugs and other xenobiotics$94077780
997   $aUNINA