LEADER 03940nam 2200625Ia 450 001 9910830087503321 005 20230617020214.0 010 $a1-280-26907-3 010 $a9786610269075 010 $a0-470-09082-0 010 $a0-470-09083-9 035 $a(CKB)111090529060254 035 $a(EBL)189446 035 $a(SSID)ssj0000204825 035 $a(PQKBManifestationID)11200636 035 $a(PQKBTitleCode)TC0000204825 035 $a(PQKBWorkID)10188722 035 $a(PQKB)11417548 035 $a(MiAaPQ)EBC189446 035 $a(OCoLC)85820034 035 $a(EXLCZ)99111090529060254 100 $a20030723d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular clocks and light signalling$b[electronic resource] /$f[editors, Derek J. Chadwick and Jamie A. Goode] 210 $aChichester, UK ;$aHoboken, NJ $cWiley$d2003 215 $a1 online resource (308 p.) 225 1 $aNovartis Foundation symposium ;$v253 300 $a"Held at the Novartis Foundation, London, 3-5 September 2002"--p. v. 311 $a0-470-85283-6 320 $aIncludes bibliographical references and indexes. 327 $aMOLECULAR CLOCKS AND LIGHT SIGNALLING; Contents; Participants; Chair's introduction; Non-rod, non-cone photoreception in rodents and teleost fish; Discussion; Cryptochromes and inner retinal non-visual irradiance detection; Discussion; General discussion I; Light signalling in Cryptochrome-deficient mice; Discussion; Circadian light input in plants, flies, and mammals; Discussion; Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators; Discussion; General discussion; SCN: ringmaster of the circadian circus or conductor of the circadian orchestra? 327 $aDiscussionOn the communication pathways between the central pacemaker and peripheral oscillators; Discussion; Central and peripheral circadian oscillators in Drosophila; Discussion; Integration of molecular rhythms in mammalian circadian system; Circadian transcriptional output in the SCN and liver of the mouse; Discussion; The molecular workings of the Neurospora biological clock; Discussion; Expression of clock gene products in the suprachiasmatic nucleus in relation to circadian behaviour; Discussion; Circadian rhythms in Drosophila; Discussion 327 $aThe role of phosphorylation and degradation of hPer proteins oscillation in normal human fibroblastsDiscussion; Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling; Discussion; CK1 and GSK-3 in the Drosophila and mammalian circadian clock; Discussion; Final general discussion; Closing remarks; Index of contributors; Subject index 330 $aThe ability at the molecular level to keep track of time is a property shared by organisms ranging from the simplest unicells to humans. The primary feature of these biological clocks is their ability to entrain to environmental stimuli. The dominant stimulus comes from environmental light cues, which requires the existence of photopigments sensitive to light. The exact identity of the molecules involved in circadian photoreception has remained elusive. The classical view of the circadian system is of diverse physiological rhythms regulated by a centralized clock structure. This book present 410 0$aNovartis Foundation symposium ;$v253. 606 $aCircadian rhythms$vCongresses 606 $aPhotobiochemistry$vCongresses 615 0$aCircadian rhythms 615 0$aPhotobiochemistry 676 $a571.4 676 $a571.7/7 676 $a571.77 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830087503321 996 $aMolecular clocks and light signalling$94036350 997 $aUNINA