LEADER 02971nam  22005774a 450 
001 9910830085003321
005 20230721033134.0
010   $a1-281-93868-8
010   $a9786611938680
010   $a0-470-40910-X
010   $a0-470-40905-3
035   $a(CKB)1000000000551811
035   $a(EBL)380501
035   $a(OCoLC)437241459
035   $a(SSID)ssj0000212701
035   $a(PQKBManifestationID)11173616
035   $a(PQKBTitleCode)TC0000212701
035   $a(PQKBWorkID)10138878
035   $a(PQKB)10551139
035   $a(MiAaPQ)EBC380501
035   $a(EXLCZ)991000000000551811
100   $a20080703d2009      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aNuclear receptors in drug metabolism$b[electronic resource] /$fedited by Wen Xie
210   $aHoboken, NJ $cJohn Wiley & Sons$dc2009
215   $a1 online resource (362 p.)
300   $aDescription based upon print version of record.
311   $a0-470-08679-3 
320   $aIncludes bibliographical references and index.
327   $aDrug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes.
330   $aThis book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.
606   $aDrugs$xMetabolism
606   $aNuclear receptors (Biochemistry)
606   $aGenetic regulation
615  0$aDrugs$xMetabolism.
615  0$aNuclear receptors (Biochemistry)
615  0$aGenetic regulation.
676   $a615.19
676   $a615/.7
701   $aXie$b Wen$f1967-$01672776
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910830085003321
996   $aNuclear receptors in drug metabolism$94036335
997   $aUNINA