LEADER 03651nam 2200625 a 450 001 9910830059703321 005 20230331005356.0 010 $a1-282-34600-8 010 $a9786612346002 010 $a0-470-51348-9 010 $a0-470-51349-7 035 $a(CKB)1000000000377311 035 $a(EBL)470679 035 $a(OCoLC)609849686 035 $a(SSID)ssj0000289519 035 $a(PQKBManifestationID)11911073 035 $a(PQKBTitleCode)TC0000289519 035 $a(PQKBWorkID)10402998 035 $a(PQKB)10120410 035 $a(MiAaPQ)EBC470679 035 $a(EXLCZ)991000000000377311 100 $a19870402d1987 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAutoimmunity and autoimmune disease$b[electronic resource] 210 $aChichester ;$aNew York $cWiley$d1987 215 $a1 online resource (290 p.) 225 1 $aCiba Foundation symposium ;$v129 300 $aEditors: David Evered (organizer) and Julie Whelan. 300 $a"Symposium on Autoimmunity and Autoimmune Disease, held at the Ciba Foundation, London, 30 September-2 October 1986"--Contents p. 300 $a"A Wiley-Interscience publication." 311 $a0-471-91095-3 320 $aIncludes bibliographical references and indexes. 327 $aAUTOIMMUNITY AND AUTOIMMUNE DISEASE; Contents; Participants; Introduction; Cardiac myosin and autoimmune myocarditis; Intracellular autoantigens: diagnostic fingerprints but aetiological dilemmas; Significance of carbohydrate components of cell surfaces; How is tolerance generated?; Therapeutic immune regulation in experimental interstitial nephritis with suppressor T cells and their soluble factors; Regulation of HL4 class II expression and its role in autoimmune disease; Id iotypes and autoimmunity 327 $aMolecular basis for the cross-reactive idiotypes on human anti-lgG autoanti bodies (rheumatoid factors)Autoimmunity and immunodeficiency disease; Deficiency of the effector mechanisms of the immune response and au toimmu n ity; General discussion; Monoclonal anti-la antibody therapy in animal models of autoimmune disease; Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes; Manipulation of idiotype networks in autoimmunity; Interferons: cytokines in autoimmunity; Specific immunoabsorption; Final general discussion; Chairman's summing-up; Index of contributors 327 $aSubject Index 330 $aThis work focuses on the autoimmune processes that have now been proven to underlie a number of serious diseases, including diabetes mellitus, rheumatoid arthritis and multiple sclerosis. Papers explore the rapidly expanding developments in research on immune response and regulation, and their potential in the development of treatments for autoimmune diseases. The wide range of subjects covered here include: the nature of intracellular and cell surface-derived ``self'' antigens; competing theories of the generation of immune tolerance and their implications of current theories for research and 410 0$aCiba Foundation symposium ;$v129. 606 $aAutoimmune diseases$vCongresses 615 0$aAutoimmune diseases 676 $a616.9 676 $a616.978 701 $aEvered$b David$0857127 701 $aWhelan$b Julie$0322651 712 12$aSymposium on Autoimmunity and Autoimmune Disease$f(1986 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830059703321 996 $aAutoimmunity and autoimmune disease$94116977 997 $aUNINA LEADER 03882nam 22007694a 450 001 9910819123303321 005 20200520144314.0 010 $a9786610264858 010 $a9781280264856 010 $a1280264853 010 $a9780471476641 010 $a0471476641 010 $a9780471476658 010 $a047147665X 035 $a(CKB)1000000000018955 035 $a(EBL)221243 035 $a(OCoLC)606162698 035 $a(SSID)ssj0000214883 035 $a(PQKBManifestationID)11201988 035 $a(PQKBTitleCode)TC0000214883 035 $a(PQKBWorkID)10167641 035 $a(PQKB)11142197 035 $a(DNLM)101175932 035 $a(MiAaPQ)EBC221243 035 $a(Au-PeEL)EBL221243 035 $a(CaPaEBR)ebr10114025 035 $a(CaONFJC)MIL26485 035 $a(Perlego)2765349 035 $a(EXLCZ)991000000000018955 100 $a20030422d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOncogenomics $emolecular approaches to cancer /$fedited by Charles Brenner, David J. Duggan 205 $a1st ed. 210 $aHoboken $cWiley-Liss$dc2004 215 $a1 online resource (411 p.) 300 $aDescription based upon print version of record. 311 08$a9780471225928 311 08$a0471225924 320 $aIncludes bibliographical references and index. 327 $aCONTENTS; Contributors; Preface; Section I INTRODUCTION; 1 AT THE PRECARIOUS CUSP OF ONCOGENOMICS; Section II MOLECULAR PROFILING IN CANCER: DNA, RNA, AND PROTEIN; 2 GENOME-WIDE SEARCHES FOR MUTATIONS IN HUMAN CANCER; 3 MOLECULAR CYTOGENETICS: INCREASING RESOLUTION USING ARRAY-BASED CGH; 4 SNPs AND FUNCTIONAL POLYMORPHISMS IN CANCER; 5 EXPRESSION PROFILING OF BREAST CANCER: FROM MOLECULAR PORTRAITS TO CLINICAL UTILITY; 6 CLASSIFYING HEREDITARY CANCERS AND PHENOCOPIES OF HEREDITARY CANCERS USING EXPRESSION ARRAYS 327 $a7 LINKING DRUGS AND GENES: PHARMACOGENOMICS, PHARMACOPROTEOMICS, BIOINFORMATICS, AND THE NCI-608 TISSUE MICROANALYSIS: PROFILING CANCER STAGES; 9 PROTEOMICS IN BLADDER CANCER; Section III MODEL SYSTEMS; 10 CHEMICAL AND GENETIC METHODS TO VALIDATE TARGETS IN NONMAMMALIAN ORGANISMS; 11 MOUSE MODELS OF CANCER; 12 GENOME-WIDE MODIFIER SCREENS: HOW THE GENETICS OF CANCER PENETRANCE MAY SHAPE THE FUTURE OF PREVENTION AND TREATMENT; Section IV MOLECULARLY TARGETED DRUGS; 13 PROTEIN KINASES AS TARGETS IN CANCER THERAPY: VALIDATED AND EMERGING APPROACHES; 14 RAS SUPERFAMILY-DIRECTED COMPOUNDS 327 $a15 CLINOMICS: POSTGENOMIC CANCER CARESection V CONCLUSION; 16 ONCOGENOMICS AND THE NCI DIRECTOR'S VISION FOR 2015; INDEX 330 $aThis book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets. 606 $aCancer$xGenetic aspects 606 $aCancer$xMolecular aspects 606 $aGenomics 606 $aProteomics 606 $aOncogenes 615 0$aCancer$xGenetic aspects. 615 0$aCancer$xMolecular aspects. 615 0$aGenomics. 615 0$aProteomics. 615 0$aOncogenes. 676 $a616.99/4042 701 $aBrenner$b Charles$f1913-2008.$056577 701 $aDuggan$b David$01714102 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910819123303321 996 $aOncogenomics$94107632 997 $aUNINA