LEADER 03658nam 2200589Ia 450 001 9910830052503321 005 20170809164724.0 010 $a1-280-26899-9 010 $a9786610268993 010 $a0-470-09048-0 010 $a0-470-09047-2 035 $a(CKB)1000000000356577 035 $a(EBL)232699 035 $a(SSID)ssj0000178876 035 $a(PQKBManifestationID)11197359 035 $a(PQKBTitleCode)TC0000178876 035 $a(PQKBWorkID)10230267 035 $a(PQKB)11698207 035 $a(MiAaPQ)EBC232699 035 $a(OCoLC)85820607 035 $a(EXLCZ)991000000000356577 100 $a20040812d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aInflammatory bowel disease$b[electronic resource] $ecrossroads of microbes, epithelium and immune systems 210 $aChichester, UK ;$aHoboken, NJ $cJ. Wiley$d2004 215 $a1 online resource (240 p.) 225 1 $aNovartis Foundation symposium ;$v263 300 $a"Symposium on Inflammatory bowel disease--crossroads of microbes, epithelium and immune systems, held at the Novartis Foundation, London, 25-27 November 2003. Editors, Dereck Chadwick (organizer) and Jamie Goode"--Contents p. 311 $a0-470-09046-4 320 $aIncludes bibliographical references and indexes. 327 $aINFLAMMATORY BOWEL DISEASE: CROSSROADS OF MICROBES, EPITHELIUM AND IMMUNE SYSTEMS; Contents; Participants; Chair's introduction; Progress towards identifying inflammatory bowel disease susceptibility genes; Discussion; Phenotype-determining genes in inflammatory bowel disease; Discussion; Pharmacogenetics of inflammatory bowel disease; Discussion; Bacterial milieu and mucosal bacteria in ulcerative colitis; Discussion; Defensins and mucosal protection; Discussion; Intestinal mycoplasma in Crohn's disease; Discussion; Probiotics, prebiotics and antibiotics in inflammatory bowel disease 327 $aDiscussionThe epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption; Discussion; Apoptosis or necrosis colonic epithelial cell survival; Discussion; Genetic aspects of intestinal permeability in inflammatory bowel disease; Discussion; Animal models of intestinal inflammation: clues to the pathogenesis of inflammatory bowel disease; Discussion; Homing of intestinal immune cells; Discussion; Anti-TNF therapy in Crohn's disease; Discussion; Final discussion; Index of contributors; Subject index 330 $aInflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as: Epithelial cell and molecular biology, including ap 410 0$aNovartis Foundation symposium ;$v263. 606 $aInflammatory bowel diseases$vCongresses 606 $aGastroenteritis$vCongresses 615 0$aInflammatory bowel diseases 615 0$aGastroenteritis 676 $a616.344 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830052503321 996 $aInflammatory bowel disease$94087587 997 $aUNINA