LEADER 05460nam 2200661Ia 450 001 9910830041303321 005 20230330142851.0 010 $a1-280-85473-1 010 $a9786610854738 010 $a0-470-02815-7 010 $a0-470-02814-9 035 $a(CKB)1000000000357336 035 $a(EBL)292555 035 $a(OCoLC)476052453 035 $a(SSID)ssj0000263467 035 $a(PQKBManifestationID)11937511 035 $a(PQKBTitleCode)TC0000263467 035 $a(PQKBWorkID)10273307 035 $a(PQKB)11710775 035 $a(MiAaPQ)EBC292555 035 $a(EXLCZ)991000000000357336 100 $a20060526d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 04$aThe ubiquitous roles of cytochrome P450 proteins$b[electronic resource] /$fedited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel 210 $aChichester $cJohn Wiley$dc2007 215 $a1 online resource (680 p.) 225 1 $aMetal ions in life sciences,$x1559-0836 ;$vv. 3 300 $aDescription based upon print version of record. 311 $a0-470-01672-8 320 $aIncludes bibliographical references and index. 327 $aMetal Ions in Life Sciences; Historical Development and Perspectives of the Series; Preface to Volume 3; Contents; Contributors to Volume 3; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; 1 Diversities and Similarities in P450 Systems: An Introduction; 1. Oxygenases: Mediators of Biochemical Diversity; 2. P450 Superfamily: Diversity at the Sequence Level; 3. Diversity of P450 Structures: Folds and Conformations for Functions; 4. Diversity in P450 Mechanisms; 5. Diversity in Regulation Across the Superfamily 327 $a6. Diversity in the Evolution of Common Metabolic Functions7. Summary and Outlook; Acknowledgments; Abbreviations; References; 2 Structural and Functional Mimics of Cytochromes P450; 1. Introduction; 2. Iron Porphyrins Carrying a Thiolate or Modified Thiolate Ligand; 3. Structurally Remote P450 Mimics; 4. Concluding Remarks; Acknowledgments; Abbreviations; References; 3 Structures of P450 Proteins and Their Molecular Phylogeny; 1. Introduction; 2. P450 Evolution; 3. P450 Families and Subfamilies; 4. P450 Structures; 5. Variation in P450 Function and Fold; 6. Archaeon P450s 327 $a7. Summary and ConclusionsAcknowledgments; Abbreviations; References; 4 Aquatic P450 Species; 1. Introduction. 'P450s Under the Surface'; 2. Diversity of Aquatic Species; 3. P450 Activities in Aquatic Invertebrates; 4. Aquatic P450 Gene Families Identified; 5. How Can We Use Information About P450s in Aquatic Species?; 6. Conclusions and Outlook; Acknowledgments; Abbreviations; References; 5 The Electrochemistry of Cytochrome P450; 1. Introduction; 2. Redox Titration (Potentiometric Equilibrium) Measurements; 3. Voltammetric (Dynamic) Measurements; 4. Conclusions; Acknowledgments 327 $aAbbreviationsReferences; 6 P450 Electron Transfer Reactions; 1. Introduction; 2. Catalytic Cycles; 3. Electron Tunneling Wires; 4. Concluding Remarks; Acknowledgments; Abbreviations; References; 7 Leakage in Cytochrome P450 Reactions in Relation to Protein Structural Properties; 1. Introduction; 2. Protein Structural Parameters; 3. The Reaction Cycle of Cytochrome P450; 4. Protein Structural Parameters and Extent of Competitive Reactions; 5. Concluding Remarks; Acknowledgments; Abbreviations; References; 8 Cytochromes P450 - Structural Basis for Binding and Catalysis; 1. Introduction 327 $a2. Ligand Binding: Substrate Recognition and Access to the Distal Pocket3. Architecture of the Active Site of CYP101; 4. The Distal Acid-Alcohol Pair; 5. Experimental Characterization of Reaction Intermediates. Radiolysis as a Tool to Study Redox Reactions; 6. Crystal Structures of Oxy-Ferrous Complexes; 7. Mechanism: Summary, Conclusions, Speculations; Acknowledgments; Abbreviations; References; 9 Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems; 1. Overview of Cytochrome P450 Active Site Structure 327 $a2. Secondary Coordination Sphere on the Proximal Side 330 $aHelmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons launch a new Series "Metal Ions in Life Sciences". There exists a whole range of books on Cytochromes P450, but none with the focus of this volume. This new volume in the Series concentrates on current hot topics in the area and tries to work out the underlying common developments. As a result the reader will find a systematic account of new results in this exciting research area. The table of contents gives an idea on the wide span of chapters, starting with overviews and the presentation of spec 410 0$aMetal ions in life sciences ;$vv. 3. 606 $aCytochrome P-450 606 $aCytochromes 615 0$aCytochrome P-450. 615 0$aCytochromes. 676 $a572.6 676 $a572.7 701 $aSigel$b Astrid$091114 701 $aSigel$b Helmut$091115 701 $aSigel$b Roland K. O$01627877 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830041303321 996 $aThe ubiquitous roles of cytochrome P450 proteins$94049146 997 $aUNINA LEADER 03309nam 2200649 a 450 001 9911019481703321 005 20200520144314.0 010 $a9786613679352 010 $a9781280768583 010 $a1280768584 010 $a9780470719039 010 $a0470719036 010 $a9780470716502 010 $a0470716509 035 $a(CKB)1000000000687501 035 $a(EBL)703749 035 $a(SSID)ssj0000715224 035 $a(PQKBManifestationID)11413551 035 $a(PQKBTitleCode)TC0000715224 035 $a(PQKBWorkID)10701061 035 $a(PQKB)11736048 035 $a(MiAaPQ)EBC703749 035 $a(OCoLC)264621034 035 $a(Perlego)2764509 035 $a(EXLCZ)991000000000687501 100 $a19861010d1957 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMethodology of the study of ageing /$feditors for the Ciba Foundation, G.E.W. Wolstenholme and Cecilia M. O'Connor 210 $aBoston $cLittle, Brown and Co.$d1957 215 $a1 online resource (226 p.) 225 1 $aCiba Foundation colloquia on ageing ;$vv. 3 300 $aDescription based upon print version of record. 311 08$a9780470722466 311 08$a0470722460 320 $aIncludes bibliographical references and indexes. 327 $aCIBA FOUNDATION COLLOQUIA ON AGEING VOLUME 3; CONTENTS; Chairman's opening remarks; The biological approach in the comparative study of ageing; The comparative biology of ageing : a physiological approach; Discussion; The study of the ageing of cells; Discussion; Examples of reactions to standard stimuli at different ages; Studies on adaptation as a method of gerontological research; Discussion; Methods and limitations in studies of human organ system function; Comparative values of studies of the whole organism and of whole tissue ; clinicopathological tests of ageing; Discussion 327 $aNutrition, liver disease and some aspects of ageing in AfricansThe use of inbred strains of animals in experimental gerontology; Discussion; Twin data on the genetics of ageing; Discussion; Methodological problems in the study of changes in human performance with age; Methodology of the study of intelligence and emotion in ageing; Discussion; General Discussion; Chairman's closing remarks 330 8 $aThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. 410 0$aCiba Foundation colloquia on ageing ;$vv. 3. 606 $aAging$vCongresses 606 $aGeriatrics$xMethodology$vCongresses 615 0$aAging 615 0$aGeriatrics$xMethodology 676 $a612.67 701 $aWolstenholme$b G. E. W$g(Gordon Ethelbert Ward)$063039 701 $aO'Connor$b Cecilia M$g(Cecilia Mary),$f1927-$0207754 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019481703321 996 $aMethodology of the study of ageing$91935444 997 $aUNINA