LEADER 05286nam 22006254a 450 001 9910830022803321 005 20170815123355.0 010 $a1-280-72142-1 010 $a9786610721429 010 $a0-470-05550-2 010 $a0-470-05549-9 035 $a(CKB)1000000000354777 035 $a(EBL)281826 035 $a(SSID)ssj0000242286 035 $a(PQKBManifestationID)11215414 035 $a(PQKBTitleCode)TC0000242286 035 $a(PQKBWorkID)10310304 035 $a(PQKB)10947325 035 $a(MiAaPQ)EBC281826 035 $a(OCoLC)86175956 035 $a(EXLCZ)991000000000354777 100 $a20060412d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aScience, society, and the supermarket$b[electronic resource] $ethe opportunities and challenges of nutrigenomics /$fDavid Castle ... [et al.] 210 $aHoboken, N.J. $cWiley-Interscience$dc2007 215 $a1 online resource (177 p.) 300 $aDescription based upon print version of record. 311 $a0-471-77000-0 320 $aIncludes bibliographical references and index. 327 $aSCIENCE, SOCIETY, AND THE SUPERMARKET; CONTENTS; Preface; Acknowledgments; 1 NUTRITIONAL GENOMICS: OPPORTUNITIES AND CHALLENGES; 1.1 Introduction; 1.2 What is Nutritional Genomics?; 1.3 Methodology and Approach of this Book; 1.4 Opportunities and Challenges for Nutrigenomics; 1.4.1 Improved health; 1.4.2 Personalized dietary advice; 1.4.3 Improved diet; 1.4.4 More development of health-enhancing food products; 1.4.5 Consumer empowerment; 1.4.6 Reducing health disparities; 1.4.7 Health care savings; 1.5 Challenges and a Road Map of This Book; References 327 $a2 THE SCIENCE OF NUTRIGENOMICS AND NUTRIGENETICS2.1 Introduction; 2.2 The Scientific Context; 2.2.1 Nutrigenomics; 2.2.2 Nutrigenetics; 2.3 The Case of MTHFR; 2.4 Room for Improvement; 2.4.1 Study design; 2.4.2 Epigenetics; 2.4.3 SNPs and haplotypes; 2.4.4 Dietary intake assessment; 2.4.5 Biomarkers; 2.4.6 Susceptibility and predictions; 2.4.7 Analytical and clinical validity; 2.4.8 Clinical utility; 2.5 Science and Technology Assessment; 2.6 Conclusion; References; 3 THE ETHICS OF NUTRIGENOMIC TESTS AND INFORMATION; 3.1 Introduction; 3.2 Ethical Principles 327 $a3.3 Nutrigenomics Testing in the Clinical Setting3.3.1 Informed consent; 3.3.2 Confidentiality; 3.3.3 Secondary information; 3.3.4 Families; 3.3.5 Genetic testing of children and adolescents; 3.4 Use of Nutrigenomics Information for Research; 3.5 Use of Nutrigenomics Information by Private Third Parties; 3.5.1 Insurance; 3.5.2 Employment; 3.5.3 Legal and social responses to fears of discrimination; 3.6 Conclusion; References; 4 ALTERNATIVES FOR NUTRIGENOMIC SERVICE DELIVERY; 4.1 Introduction; 4.2 Considerations for Nutrigenomic Service Delivery; 4.2.1 Strength of the science 327 $a4.2.2 Regulatory environment4.2.3 Human resource capacity and professional competence; 4.2.4 Funding policy; 4.2.5 Professional politics and culture; 4.2.6 Consumers and patients; 4.3 Four Alternative Models; 4.3.1 Consumer model; 4.3.2 Health practitioner model; 4.3.3 Blended models; 4.3.4 Public health model; 4.4 Conclusion; References; 5 NUTRIGENOMICS AND THE REGULATION OF HEALTH CLAIMS FOR FOODS AND DRUGS; 5.1 Introduction; 5.1.1 Genetic tests, service delivery, and genetic antidiscrimination; 5.2 Food Categories: Functional Foods, Nutraceuticals, Medicinal Foods, and Dietary Supplements 327 $a5.2.1 Functional foods5.2.2 Nutraceuticals; 5.2.3 Medical or medicinal foods; 5.2.4 Dietary supplements; 5.3 Health-Related Claims Associated with Foods Compared to Drugs; 5.3.1 Structure-function claims; 5.3.2 Health claims; 5.3.3 Medical food claims; 5.3.4 Disease risk reduction claims; 5.4 Nutrigenomic Information and the Regulation of Foods Compared to Drugs; 5.4.1 The regulation of foods; 5.4.2 The regulation of drugs; 5.5 Food and Drug Regulations in Japan, the United States, and Canada; 5.5.1 Japan; 5.5.2 United States; 5.5.3 Canada; 5.6 Conclusion; References 327 $a6 NUTRIGENOMICS: JUSTICE, EQUITY, AND ACCESS 330 $aThe new science of nutrigenomics and its ethical and societal challengesGene-diet interactions--which underlie relatively benign lactose intolerance to life-threatening conditions such as cardiovascular disease--have long been known. But until now, scientists lacked the tools to fully understand the underlying mechanisms that cause these conditions. In recent years, however, strides in human genomics and the nutritional sciences have allowed for the advancement of a new science--dubbed nutrigenomics. 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