LEADER 03796nam 2200649Ia 450 001 9910829928703321 005 20230422044838.0 010 $a1-282-34811-6 010 $a9786612348112 010 $a0-470-51558-9 010 $a0-470-51559-7 035 $a(CKB)1000000000377222 035 $a(EBL)470537 035 $a(OCoLC)609849480 035 $a(SSID)ssj0000297206 035 $a(PQKBManifestationID)11223352 035 $a(PQKBTitleCode)TC0000297206 035 $a(PQKBWorkID)10333470 035 $a(PQKB)10729532 035 $a(MiAaPQ)EBC470537 035 $a(EXLCZ)991000000000377222 100 $a19981020d1999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGap junction-mediated intercellular signalling in health and disease$b[electronic resource] 210 $aChichester ;$aNew York $cWiley$d1999 215 $a1 online resource (299 p.) 225 1 $aNovartis Foundation symposium ;$v219 300 $aOrganizer and editor: Gail Cardew. 300 $aBased on a symposium held at the Novartis Foundation, London 2-5 March 1998. 311 $a0-471-98259-8 320 $aIncludes bibliographical references and indexes. 327 $aGAP JUNCTION-MEDIATED INTERCELLULAR SIGNALLING IN HEALTH AND DISEASE; Contents; Participants; Introduction; Molecular biology of the interactions between connexins; Electron cryo-crystallography of a recombinant cardiac gap junction channel; General discussion I; Trafficking pathways leading to the formation of gap junctions; Interactions between growth factors and gap junctional communication in developing systems; Biological functions of connexin genes revealed by human genetic defects, dominant negative approaches and targeted deletions in the mouse 327 $aConnexins in the lens: are they to blame in diabetic cataractogenesis?Neuronal coupling in the central nervous system: lessons from the retina; Gap junctions and connexin expression in the inner ear; Gap junction-mediated communication in the developing and adult cerebral cortex; The role of the gap junction protein connexin32 in the pathogenesis of X-linked Charcot-Marie-Tooth disease; Cardiovascular disease; Misregulation of connexin43 gap junction channels and congenital heart defects; Gap junctional intercellular communication in the mouse ovarian follicle 327 $aConnexins in tumour suppression and cancer therapySummary; Index of contributors; Subject index 330 $aGap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin o 410 0$aNovartis Foundation symposium ;$v219. 606 $aGap junctions (Cell biology)$vCongresses 606 $aConnexins$vCongresses 606 $aCellular signal transduction$vCongresses 615 0$aGap junctions (Cell biology) 615 0$aConnexins 615 0$aCellular signal transduction 676 $a571.6 676 $a611.018 701 $aCardew$b Gail$0857118 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910829928703321 996 $aGap junction-mediated intercellular signalling in health and disease$93976317 997 $aUNINA