LEADER 03731nam 2200625Ia 450 001 9910829925903321 005 20230421044622.0 010 $a1-282-12249-5 010 $a9786612122491 010 $a0-470-51552-X 010 $a0-470-51553-8 035 $a(CKB)1000000000377314 035 $a(EBL)470649 035 $a(SSID)ssj0000361487 035 $a(PQKBManifestationID)11290280 035 $a(PQKBTitleCode)TC0000361487 035 $a(PQKBWorkID)10366744 035 $a(PQKB)11665246 035 $a(MiAaPQ)EBC470649 035 $a(OCoLC)181186422 035 $a(EXLCZ)991000000000377314 100 $a19980217d1998 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aImmunological tolerance$b[electronic resource] /$f[editors, Gregory R. Bock (organizer) and Jamie A. Goode] 210 $aChichester ;$aNew York $cJ. Wiley & Sons$d1998 215 $a1 online resource (250 p.) 225 1 $aNovartis Foundation symposium ;$v215 300 $a"Symposium on Immunological Tolerance, held at the Novartis Foundation, London, 8-10 July 1997"--P. v. 311 $a0-471-97843-4 320 $aIncludes bibliographical references and indexes. 327 $aIMMUNOLOGICAL TOLERANCE; Contents; Participants; Introduction; Mechanisms of peripheral T cell tolerance; B cell antigen receptor signalling in the balance of tolerance and immunity; General discussion I; The study of self-tolerance using murine haemoglobin as a model self antigen; Tolerance and determinant hierarchy; Molecular genetic studies in lymphocyte apoptosis and human autoimmunity; General discussion II; A role for CTLA-4-mediated inhibitorv J signals in peripheral T cell tolerance? 327 $aAntigen-specific CD4+ T cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defectAntigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease; Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes; Tolerance induction with CD4 monoclonal antibodies; A two-step model for the induction of organ-specific autoimmunity; Cross-presentation of self antigens to CDW T cells: the balance between tolerance and autoimmunity; General discussion III 327 $aTolerance induction in mature T lymphocytesT lymphocyte-mediated control of autoimmunity; Final general discussion; Index of contributors; Subject index 330 $aThis book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during 410 0$aNovartis Foundation symposium ;$v215. 606 $aImmunological tolerance$vCongresses 606 $aAutoimmunity$vCongresses 615 0$aImmunological tolerance 615 0$aAutoimmunity 676 $a571.96 676 $a616.079 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 712 12$aSymposium on Immunological Tolerance$f(1997 :$eNovartis Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910829925903321 996 $aImmunological tolerance$93935832 997 $aUNINA