LEADER 05463nam 2200721Ia 450 001 9910829885503321 005 20170810183230.0 010 $a1-282-46293-8 010 $a9786612462931 010 $a3-527-62954-8 010 $a3-527-62955-6 035 $a(CKB)2550000000006859 035 $a(EBL)481266 035 $a(OCoLC)609687946 035 $a(SSID)ssj0000357794 035 $a(PQKBManifestationID)11269937 035 $a(PQKBTitleCode)TC0000357794 035 $a(PQKBWorkID)10358985 035 $a(PQKB)10401334 035 $a(MiAaPQ)EBC481266 035 $a(NjHacI)992550000000006859 035 $a(EXLCZ)992550000000006859 100 $a20090911d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aChiral amine synthesis$b[electronic resource] $emethods, developments and applications /$fedited by Thomas C. Nugent 210 $aWeinheim $cWiley-VCH Verlag GmbH & Co.$d2010 215 $a1 online resource (522 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32509-3 320 $aIncludes bibliographical references and index. 327 $aChiral Amine Synthesis; Foreword; Contents; Preface; List of Contributors; 1 Stereoselective Synthesis of a-Branched Amines by Nucleophilic Addition of Unstabilized Carbanions to Imines; 1.1 Introduction; 1.2 Overview of the Methods for the Preparation of Imines; 1.2.1 N-Aryl and N-Alkyl Imines and Hydrazones; 1.2.2 N-Sulfinyl Imines; 1.2.3 N-Sulfonyl Imines; 1.2.4 N-Phosphinoyl Imines; 1.2.5 N-Acyl and N-Carbamoyl Imines; 1.3 Chiral Auxiliary-Based Approaches; 1.3.1 Imines Derived from Chiral Aldehydes; 1.3.2 Imines Bearing a Chiral Protecting/Activating Group 327 $a1.4 Catalytic Asymmetric Nucleophilic Addition to Achiral Imines1.4.1 Catalytic Asymmetric Addition of sp3 Hybridized Carbanions; 1.4.1.1 Copper-Catalyzed Dialkylzinc Additions; 1.4.1.2 Zinc Alkoxide-Catalyzed Dialkylzinc Additions; 1.4.1.3 Early Transition Metal (Zr, Hf)-Catalyzed Dialkylzinc Additions; 1.4.1.4 Rhodium-Catalyzed Dialkylzinc Addition Reactions; 1.4.2 Catalytic Asymmetric Allylation of Imines; 1.4.3 Catalytic Asymmetric Addition of sp2 Hybridized Carbanions; 1.4.3.1 Catalytic Asymmetric Vinylation; 1.4.3.2 Catalytic Asymmetric Arylation 327 $a1.4.3.2.1 Amino Alcohol-Catalyzed Addition of Organozinc Reagents1.4.3.2.2 Rhodium Phosphine-Catalyzed Arylation of Imines; 1.4.3.2.3 Rhodium Diene-Catalyzed Arylation of Imines; 1.4.4 Catalytic Asymmetric Addition of sp Hybridized Carbanions; 1.5 Conclusion; References; 2 Asymmetric Methods for Radical Addition to Imino Compounds; 2.1 Background and Introduction; 2.2 Intermolecular Radical Addition Chiral N-Acylhydrazones; 2.2.1 Design of Chiral N-Acylhydrazones; 2.2.2 Preparation of Chiral N-Acylhydrazones; 2.2.3 Tin-Mediated Addition of Secondary and Tertiary Radicals 327 $a2.2.4 Tin-Free Radical Addition2.2.5 Manganese-Mediated Radical Addition; 2.2.6 Manganese-Mediated Coupling with Multifunctional Precursors; 2.2.6.1 Hybrid Radical-Ionic Annulation; 2.2.6.2 Precursors Containing Hydroxyl or Protected Hydroxyl Groups; 2.2.6.3 Ester-Containing N-Acylhydrazones; 2.2.6.4 Additions to Ketone Hydrazones; 2.3 Asymmetric Catalysis of Radical Addition; 2.4 Closing Remarks; References; 3 Enantioselective Synthesis of Amines by Chiral Brønsted Acid Catalysts; 3.1 Introduction; 3.2 Carbon-Carbon Bond Forming Reactions; 3.2.1 Mannich and Related Reactions 327 $a3.2.1.1 Mannich Reaction3.2.1.2 Nucleophilic Addition of Diazoacetates to Aldimine; 3.2.1.3 Vinylogous Mannich Reaction; 3.2.1.4 Aza-Petasis-Ferrier Rearrangement; 3.2.2 One-Carbon Homologation Reactions; 3.2.2.1 Strecker Reaction; 3.2.2.2 Aza-Henry Reaction; 3.2.2.3 Imino-Azaenamine Reaction; 3.2.3 Friedel-Crafts and Related Reactions; 3.2.3.1 Friedel-Crafts Reaction via Activation of Aldimines; 3.2.3.2 Friedel-Crafts Reaction via Activation of Electron-Rich Alkenes; 3.2.3.3 Pictet-Spengler Reaction; 3.2.4 Cycloaddition Reactions 327 $a3.2.4.1 Hetero-Diels-Alder Reaction of Aldimines with Siloxydienes 330 $aThis first comprehensive presentation of this hot and important topic compiles the most up-to-date methods for chiral amine synthesis. The international list of authors reads like a ""Who's Who"" of the subject, providing a large array of highly practical information concentrated into the useful and essential methods.Following an introductory chapter devoted to helping readers quickly determine which strategies to choose for their investigation, this handbook and ready reference focuses on the examination of methods that are reliable and simultaneously efficient for the synthesis of struc 606 $aChirality 606 $aAmines 608 $aHandbook 608 $ahandbooks.$2aat 608 $aReference works$2fast 608 $aHandbooks and manuals$2fast 608 $aHandbooks and manuals.$2lcgft 608 $aReference works.$2lcgft 608 $aGuides et manuels.$2rvmgf 608 $aOuvrages de re?fe?rence.$2rvmgf 615 0$aChirality. 615 0$aAmines. 676 $a547.042 686 $a540$2sdnb 702 $aHartwig$b John 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910829885503321 996 $aChiral amine synthesis$94106609 997 $aUNINA