LEADER 04811nam 2200733 450 001 9910829073803321 005 20230501055453.0 010 $a1-4426-5691-3 010 $a1-4426-3360-3 024 7 $a10.3138/9781442656918 035 $a(CKB)3710000000433164 035 $a(EBL)3432190 035 $a(OCoLC)929153904 035 $a(SSID)ssj0001540140 035 $a(PQKBManifestationID)11902545 035 $a(PQKBTitleCode)TC0001540140 035 $a(PQKBWorkID)11533599 035 $a(PQKB)11464621 035 $a(MiAaPQ)EBC4669417 035 $a(CEL)449967 035 $a(OCoLC)914233179 035 $a(CaBNVSL)thg00930793 035 $a(DE-B1597)465759 035 $a(OCoLC)1002274295 035 $a(OCoLC)1004879929 035 $a(OCoLC)1011463178 035 $a(OCoLC)1013950768 035 $a(OCoLC)979581168 035 $a(OCoLC)999361843 035 $a(DE-B1597)9781442656918 035 $a(Au-PeEL)EBL4669417 035 $a(CaPaEBR)ebr11255950 035 $a(OCoLC)958514066 035 $a(OCoLC)1082817947 035 $a(MdBmJHUP)musev2_107142 035 $a(EXLCZ)993710000000433164 100 $a20160919h19631963 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSelected papers of Charles H. Best 210 1$a[Toronto, Ontario] :$cUniversity of Toronto Press,$d1963. 210 4$dİ1963 215 $a1 online resource (758 p.) 225 0 $aHeritage 311 $a1-4426-5187-3 320 $aIncludes bibliographical references. 327 $aForeword -- Preface -- Introduction -- Insulin and glucagon -- Choline and lipotropic phenomena -- Other physiological studies -- General papers -- Epilogue. 330 $aThe name of Charles H. Best, co-discoverer of insulin, Head of the Department of Physiology and Director of the Banting and Best Department of Medical Research in the University of Toronto, is familiar to medical and lay readers all over the world. The story of his early insulin research with Dr. Frederick Banting, as a result of which men and women and children who forty years ago would have had only months or days to live are now spared, has been one of the most dramatic in the annals of medicine. This volume records the achievements of forty years of medical research, giving direct and easy access to over sixty of Dr. Best's original important research papers in the fields particularly of insulin, heparin, and choline. It opens with the early papers describing the discovery of insulin, and continues with those dealing with its preparation, extraction, physiologic effects and first clinical applications. Dr. Best has also looked back over the record as given in these papers and provided informative and informal bridges between them which place them in historical perspective. Among medical scientists Dr. Best is equally well known for initiating and developing modern knowledge of heparin and its use in controlling unwanted clotting of the blood (thrombosis). The discovery of the nutritional importance of choline as a dietary factor that protects the liver was made by Dr. Best and his colleagues in 1932 and this subject has received continued study in Toronto. A number of papers dealing with choline and its dietary precursors (the so-called lipotropic agents) are reproduced in these pages. Other papers discuss the action of histamine, the pioneer Canadian work on collection and storage of blood serum and early experiences with the preparation of dried serum. A brief account of the contribution of Dr. Best and his colleagues to the Naval Medicine is included. Medical readers will find here a valuable condensation of all the enormous body of information on these subjects. All the references in the original papers have been re-assembled in a master bibliography which is a new and full storehouse of references. Most of the papers collected in this volume have been produced in collaboration with medical colleagues to whom Dr. Best at all times gives full and enthusiastic recognition. Indeed readers will receive a strong impression that while co-operation and collaboration in medicine are nothing new, the various teams assembled by Dr. Best at the University of Toronto have had an especially remarkable dedication and sense of excitement in the adventure of medical research. 606 $aMedicine 608 $aCollected Work 608 $aElectronic books. 615 0$aMedicine. 676 $a610.8 700 $aBest$b Charles Herbert, $4aut$4http://id.loc.gov/vocabulary/relators/aut.$012827 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910829073803321 996 $aSelected papers of Charles H. Best$93965378 997 $aUNINA