LEADER 04314nam 2200601Ia 450 001 9910828757303321 005 20240313211440.0 010 $a1-84755-809-7 035 $a(CKB)1000000000791372 035 $a(CaPaEBR)ebrary10618686 035 $a(SSID)ssj0000379288 035 $a(PQKBManifestationID)11300118 035 $a(PQKBTitleCode)TC0000379288 035 $a(PQKBWorkID)10365288 035 $a(PQKB)11641078 035 $a(MiAaPQ)EBC1185426 035 $a(Au-PeEL)EBL1185426 035 $a(CaPaEBR)ebr10618686 035 $a(OCoLC)506361067 035 $a(PPN)198467966 035 $a(MiAaPQ)EBC7425035 035 $a(Au-PeEL)EBL7425035 035 $a(EXLCZ)991000000000791372 100 $a20080430d2008 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDynamic stereochemistry of chiral compounds $eprinciples and applications /$fChristian Wolf 205 $a1st ed. 210 $aCambridge, UK $cRSC Publishing$dc2008 215 $a1 online resource (533 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a1-61583-357-9 311 $a0-85404-246-6 320 $aIncludes bibliographical references and index. 327 $a9780854042463 -- i_iv -- v_viii -- ix_xii -- xiii_xviii -- xix_xx -- 001_005 -- 006_028 -- 029_135 -- 136_179 -- 180_203 -- 204_330 -- 331_398 -- 399_443 -- 444_479 -- 480_502 -- 503_512. 330 $aThis book provides an overview of fundamental concepts of asymmetric synthesis highlighting the significance of stereochemical and stereodynamic reaction control. Topics include kinetic resolution (KR), dynamic kinetic resolution (DKR), dynamic kinetic asymmetric transformation (DYKAT), and dynamic thermodynamic resolution (DTR). In-depth discussions of asymmetric synthesis with chiral organolithium compounds, atropisomeric biaryl synthesis, self-regeneration of stereogenicity (SRS), chiral amplification with chiral relays and other commonly used strategies are also provided. Particular emphasis is given to selective introduction, interconversion and translocation of central, axial, planar, and helical chirality. A systematic coverage of stereochemical principles and stereodynamic properties of chiral compounds guides the reader through the book and establishes a conceptual linkage to asymmetric synthesis, molecular devices that resemble the structure and stereomutations of propellers, bevel gears, switches and motors, and topologically chiral assemblies such as catenanes and rotaxanes.Racemization and diastereomerization reactions of numerous chiral compounds are discussed as well as the principles, scope and compatibility of commonly used analytical techniques. Details of analytical methods are provided and discussed as well as topics relating to the design of fascinating topologically chiral assemblies and molecular technomimetic devices in the context of dynamic stereochemistry. Strategies and recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples, applications and detailed mechanisms.This exceptional book includes: - More than 550 figures, schemes and tables illustrating mechanisms of numerous asymmetric reactions and stereomutations of chiral compounds - Technical drawings 330 8 $aillustrating the conceptual linkage between macroscopic devices such as turnstiles, ratchets, brakes, bevel gears or knots and molecular analogs - More than 3000 references to encourage further reading and facilitate additional literature research - A comprehensive glossary with stereochemical definitions and terms which facilitate understanding and reinforce learning This book will be of particular interest to undergraduates, graduates and professionals working and researching in the fields of organic synthetic chemistry and analytical chemistry. 606 $aStereochemistry 606 $aChirality 615 0$aStereochemistry. 615 0$aChirality. 676 $a541.223 700 $aWolf$b Christian$f1968-$01662433 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828757303321 996 $aDynamic stereochemistry of chiral compounds$94019130 997 $aUNINA