LEADER 05659nam 2200685 450 001 9910828715703321 005 20200520144314.0 010 $a0-12-803877-2 010 $a0-12-803876-4 035 $a(CKB)3710000000463840 035 $a(EBL)2189947 035 $a(SSID)ssj0001551748 035 $a(PQKBManifestationID)16169598 035 $a(PQKBTitleCode)TC0001551748 035 $a(PQKBWorkID)14812525 035 $a(PQKB)11521883 035 $a(MiAaPQ)EBC2189947 035 $a(Au-PeEL)EBL2189947 035 $a(CaPaEBR)ebr11091596 035 $a(CaONFJC)MIL823997 035 $a(OCoLC)928738451 035 $a(PPN)192172190 035 $a(EXLCZ)993710000000463840 100 $a20150901d2015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMechanism of the anticancer effect of phytochemicals /$fedited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA 205 $aFirst edition. 210 1$aWaltham, MA :$cElsevier Science,$d2015. 215 $a1 online resource (285 p.) 225 1 $aEnzymes,$x1874-6047 ;$vvolume 37 300 $aDescription based upon print version of record. 320 $aIncludes bibliographical references and indexes. 327 $aFront Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes 327 $a3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. Adjuvant/Combinatorial Therapy; 4. Summary; References 327 $aChapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetins? Effect on Apoptosis 327 $a2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetins? Role as an Anti-Inflammatory Agent; 2.8. Quercetins? Influence on p53; 2.9. Quercetins? Nontoxicity Against Normal Cells; 2.10. Quercetins? Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity 327 $a3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action 327 $aReferences 330 $aVolume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of the Enzyme series was on the topic of Natural Products and Cancer Signaling Targets: Isoprenoids, Polyphenols and Flavonoids), will highlight the significant advance made in the field in elucidating mechanisms of anticancer effect of the major phytochemicals. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field 410 0$aEnzymes ;$vv. 37. 606 $aCancer$xChemoprevention 606 $aCancer$xDiet therapy 606 $aPhytochemicals$xTherapeutic use 615 0$aCancer$xChemoprevention. 615 0$aCancer$xDiet therapy. 615 0$aPhytochemicals$xTherapeutic use. 676 $a616.994061 702 $aBathaie$b S. Zahra 702 $aTamanoi$b Fuyuhiko 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828715703321 996 $aMechanism of the anticancer effect of phytochemicals$94036745 997 $aUNINA