LEADER 05553nam 2200757Ia 450 001 9910828472103321 005 20200520144314.0 010 $a9786610541614 010 $a9781280541612 010 $a128054161X 010 $a9780470094099 010 $a0470094095 010 $a9780470011744 010 $a0470011742 035 $a(CKB)1000000000018869 035 $a(EBL)228340 035 $a(OCoLC)559997245 035 $a(SSID)ssj0000119185 035 $a(PQKBManifestationID)11136322 035 $a(PQKBTitleCode)TC0000119185 035 $a(PQKBWorkID)10057926 035 $a(PQKB)10962925 035 $a(MiAaPQ)EBC228340 035 $a(Au-PeEL)EBL228340 035 $a(CaPaEBR)ebr10113937 035 $a(CaONFJC)MIL54161 035 $a(OCoLC)1171619220 035 $a(FINmELB)ELB178947 035 $a(Perlego)2754210 035 $a(EXLCZ)991000000000018869 100 $a20040223d2004 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCell motility $efrom molecules to organisms /$fedited by Anne Ridley, Michelle Peckham, Peter Clark 205 $a1st ed. 210 $aChichester $cWiley$dc2004 215 $a1 online resource (374 p.) 300 $aDescription based upon print version of record. 311 08$a9780470848722 311 08$a0470848723 320 $aIncludes bibliographical references and index. 327 $aCell Motility From molecules to organisms; Contents; Preface; List of Contributors; 1 Molecular Mechanisms Regulating Actin Filament Dynamics at the Leading Edge of Motile Cells; Inventory of components; The ground state of the system; Signalling pathways; Activation of the Arp2/3 complex; Growth of the branched actin filament network; Filament ageing, remodeling and disassembly; Recycling ADP-actin subunits; Reaction to a chemoattractant; Reaction to the withdrawal of a chemoattractant; Acknowledgements; References; 2 The Role of Talin and Myosin VII in Adhesion - A FERM Connection 327 $aAdhesion receptors in Dictyostelium Links between the Dictyostelium cytoskeleton and adhesion; A link between M7 and talin?; The relationship of DdM7 to another FERM myosin, M10; Conclusions; Acknowledgements; References; 3 Do Class I Myosins exert their Functions through Regulation of Actin Dynamics?; Introduction; Structure function analysis of Class I myosins; Phenotypes resulting from manipulation of class I myosins; Class I myosins and the actin dynamics connection; Conclusions and outlook; Acknowledgements; References; 4 Ephrin-regulated Contact Repulsion of Growth Cones; Introduction 327 $aEph receptor and ephrin families Eph recepinductor/ephrin regulation of axon guidance; Eph receptor/ephrin mediated control of cell segregation; Eph receptor/ephrin signalling; Eph receptor activation by soluble ephrins rapidly stimulates the assembly of filamentous actin structures in fibroblast cells; EphB2 and EphA7 ed lamellipodial protrusion is mediated by the small GTPase Rac; Role of Rho GTPases in ephrin induced growth cone collapse; Conclusions; References; 5 Interplay between the Actin Cytoskeleton, Focal Adhesions and Microtubules; Introduction 327 $aActin, microtubules and cell-matrix adhesions in crawling cell locomotion Mechanosensory function of focal adhesion's and its modulation by microtubules; mDia1 as a possible coordinator of actin, focal adhesion's and microtubule assembly; Conclusion and perspectives; References; 6 Initial Steps from Cell Migration to Cell-cell Adhesion; Introduction; Epithelial cell-cell adhesion complexes; Molecular interactions and functions of classical cadherins; Examining E-cadherin distribution during cell-cell adhesion in live cells; Mechanistic insights into E-cadherin function during cell-cell adhesion 327 $aThe role of Rho family small GTPases and membrane dynamics in cell-cell adhesion Rac1-containing lamellipodia drive cell-cell contact formation between MDCK cells; Cell-cell contact induces changes in Rac1 complexes; Effects of Rac1 mutant expression on endogenous Rac 1 complexes and cell behaviour; Linking Rac1 complexes back to mechanisms of cell-cell adhesion; Acknowledgements; References; 7 Using Bioprobes to follow Protein Dynamics in Living Cells; Fluorescence resonance energy transfer (FRET); Fluorescence lifetime imaging microscopy (FLIM) 327 $aTotal internal reflection fluorescence (TIRF)/evanescent wave microscopy 330 $aRecent advances in molecular and biophysical techniques, particularly fluorescence and live cell imaging, are revolutionizing the study of cell motility. New bioprobes not only reveal simple intracellular localization, but also contain details of post-translational modifications, conformational state and protein-protein interactions. Coupling these insights with complementary advances in genetic and biochemical methods is enabling scientists to understand the processes involved in cell motility - from molecular motors to cell movements in vivo in a range of organisms and cell types. 606 $aCells$xMotility 606 $aCells 615 0$aCells$xMotility. 615 0$aCells. 676 $a571.67 701 $aRidley$b Anne$01621463 701 $aPeckham$b Michelle$01621464 701 $aClark$b Peter$f1956-$0319304 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828472103321 996 $aCell motility$93954739 997 $aUNINA