LEADER 10564nam 2200637Ia 450 001 9910828353303321 005 20200520144314.0 010 $a1-280-24619-7 010 $a9786610246199 010 $a0-309-56792-0 035 $a(CKB)110986584750618 035 $a(OCoLC)57733176 035 $a(CaPaEBR)ebrary10071445 035 $a(SSID)ssj0000138783 035 $a(PQKBManifestationID)11146111 035 $a(PQKBTitleCode)TC0000138783 035 $a(PQKBWorkID)10100894 035 $a(PQKB)10265321 035 $a(MiAaPQ)EBC3377417 035 $a(Au-PeEL)EBL3377417 035 $a(CaPaEBR)ebr10071445 035 $a(CaONFJC)MIL24619 035 $a(OCoLC)923270430 035 $a(EXLCZ)99110986584750618 100 $a19820910d1982 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDiet, nutrition, and cancer /$fCommittee on Diet, Nutrition, and Cancer, Assembly of Life Sciences, National Research Council 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1982 215 $a1 online resource (xii, 478 pages) $cillustrations 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a0-309-03280-6 320 $aIncludes bibliographies. 327 $aDiet, Nutrition, and Cancer -- Copyright -- Preface -- Contents -- 1 Executive Summary -- SUMMARY AND CONCLUSIONS -- Dietary Patterns and Components of Food -- Total Caloric Intake -- Lipids (Fats and Cholesterol) -- Protein -- Carbohydrates -- Dietary Fiber -- Vitamins -- Minerals -- Inhibitors of Carcinogenesis -- Alcohol -- Naturally Occurring Carcinogens -- Mutagens in Foods -- Food Additives -- Environmental Contaminants -- Contribution of Diet to Overall Risk of Cancer -- INTERIM DIETARY GUIDELINES -- 2 Cancer: Its Nature and Relationship to Diet -- THE NATURE OF CANCER -- The Control of Cell Division During the Growth and Replacement of Normal Tissues -- Various Abnormalities of Cell Behavior -- Cancer and Cell Heredity -- The Varying Incidence of Cancer -- Experimentally Induced Carcinogenesis -- THE CAUSES OF CANCER -- THE INFLUENCE OF DIET ON EXPERIMENTALLY INDUCED CANCERS -- The Early Stages of Carcinogenesis -- The Late Stages of Carcinogenesis -- REFERENCES -- 3 Methodology -- EPIDEMIOLOGICAL METHODS -- General Approaches -- Methods For Determining Dietary Intake -- Overall Assessment of Epidemiological Approaches -- LABORATORY METHODS -- Analysis of Molecular Structure -- Short-Term Tests -- Long-Term Bioassays -- Difficulties in Studying the Carcinogenicity and Mutagenicity of Food Constituents -- COMMITTEE'S APPROACH TO EVALUATION OF THE LITERATURE -- SUMMARY AND CONCLUSIONS -- REFERENCES -- SECTION A THE RELATIONSHIP BETWEEN NUTRIENTS AND CANCER -- CHANGES IN THE FOOD SUPPLY -- SUMMARY AND CONCLUSIONS -- REFERENCES -- 4 Total Caloric Intake -- EPIDEMIOLOGICAL EVIDENCE -- EXPERIMENTS IN ANIMALS -- SUMMARY AND CONCLUSIONS -- Epidemiological Evidence -- Experimental Evidence -- REFERENCES -- 5 Lipids (Fats and Cholesterol) -- EPIDEMIOLOGICAL EVIDENCE -- Fats -- Cholesterol. 327 $aRELATIONSHIP OF FECAL STEROID EXCRETION TO BOWEL CARCINOGENESIS -- EXPERIMENTAL EVIDENCE -- Mammary Tumors -- Hepatic and Pancreatic Cancer -- Intestinal Cancer -- SUMMARY -- Epidemiological Evidence -- Relationship of Fecal Steroid Excretion to Bowel Carcinogenesis -- Experimental Evidence -- CONCLUSIONS -- REFERENCES -- 6 Protein -- EPIDEMIOLOGICAL EVIDENCE -- Breast Cancer -- Large Bowel Cancer -- Pancreatic Cancer -- Other Cancers -- EXPERIMENTAL EVIDENCE -- Spontaneous Tumors -- Chemically Induced Tumors -- Tumor Transplantation Studies -- An Evaluation of the Data from Animal Studies -- SUMMARY -- Epidemiological Evidence -- Experimental Evidence -- CONCLUSION -- REFERENCES -- 7 Carbohydrates -- EPIDEMIOLOGICAL EVIDENCE -- EXPERIMENTAL EVIDENCE -- Sucrose -- Lactose -- Glucose -- Xylitol -- SUMMARY -- Epidemiological Evidence -- Experimental Evidence -- CONCLUSION -- REFERENCES -- 8 Dietary Fiber -- EPIDEMIOLOGICAL EVIDENCE -- EXPERIMENTAL EVIDENCE -- SUMMARY -- Epidemiological Evidence -- Experimental Evidence -- CONCLUSION -- REFERENCES -- 9 Vitamins -- VITAMIN A -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- VITAMIN C (ASCORBIC ACID) -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- VITAMIN E (?-TOCOPHEROL) -- Epidemiological Evidence -- Experimental Evidence -- Summary and Conclusions -- CHOLINE AND SELECTED B VITAMINS -- Epidemiological Studies -- Experimental Studies -- Summary and Conclusions -- REFERENCES -- 10 Minerals -- SELENIUM -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- ZINC -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- IRON -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- COPPER -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- IODINE. 327 $aEpidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- MOLYBDENUM -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- CADMIUM -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- ARSENIC -- Epidemiological Evidence -- Experimental Evidence -- Summary and Conclusions -- LEAD -- Epidemiological Evidence -- Experimental Evidence -- Summary -- Conclusion -- REFERENCES -- 11 Alcohol -- EPIDEMIOLOGICAL EVIDENCE -- Specific Alcoholic Beverages -- Total Alcoholic Beverages -- Synergism Between Alcohol and Smoking -- Effect of Nutritional Status -- EXPERIMENTAL EVIDENCE -- Postulated Mechanisms of Action in Carcinogenesis -- Alcohol and Induction of Microsomal Enzymes -- Occurrence of Putative Carcinogens in Alcoholic Beverages -- SUMMARY AND CONCLUSIONS -- REFERENCES -- SECTION B THE ROLE OF NONNUTRITIVE DIETARY CONSTITUENTS -- FOOD ADDITIVES -- CONTAMINANTS -- THE DELANEY CLAUSE AND OTHER REGULATORY ACTIONS -- EXPOSURE OF HUMANS -- THE CARCINOGENICITY OF FOOD ADDITIVES AND CONTAMINANTS -- ASSESSMENT OF EFFECTS ON HUMAN HEALTH -- REFERENCES -- 12 Naturally Occurring Carcinogens -- MYCOTOXINS -- Aflatoxins -- Other Mycotoxins -- Summary and Conclusions: Aflatoxins and Other Mycotoxins -- HYDRAZINES IN MUSHROOMS -- Agaricus bisporus -- Gyromitra esculenta -- Summary and Conclusions: Hydrazines -- PLANT CONSTITUENTS AND METABOLITES -- Pyrrolizidine Alkaloids -- Allylic and Propenylic Benzene Derivatives -- Bracken Fern Toxin(s) -- Estrogenic Compounds -- Coffee -- Methylxanthines -- Cycasin -- Thiourea -- Tannic Acid and Tannins -- Coumarin -- Parasorbic Acid -- METABOLITES OF ANIMAL ORIGIN -- Tryptophan and Its Metabolites -- Hormones -- FERMENTATION PRODUCT -- Ethyl Carbamate (Urethan) -- NITRATE, NITRITE, AND N-NITROSO COMPOUNDS -- Epidemiological Evidence. 327 $aExperimental Evidence: Carcinogenicity -- Experimental Evidence: Mutagenicity -- Summary and Conclusions: Nitrate, Nitrite, and N-Nitroso Compounds -- SUMMARY AND CONCLUSIONS -- REFERENCES -- 13 Mutagens in Food -- MUTAGENS RESULTING FROM COOKING OF FOODS -- Benzo[a]pyrene and Other Polynuclear Aromatic Hydrocarbons -- Mutagens from Pyrolyzed Proteins and Amino Acids -- Mutagens Formed from Meat at Lower Temperatures -- Mutagen Formation Involving Carbohydrates -- PLANT FLAVONOIDS -- MUTAGENIC ACTIVITY IN EXTRACTS OF FOODS AND BEVERAGES -- MODIFIERS OF MUTAGENIC ACTIVITY -- Harman and Norharman -- Hemin -- Fatty Acids -- Nitrite -- Antioxidants -- SUMMARY AND CONCLUSIONS -- REFERENCES -- 14 Additives and Contaminants -- ADDITIVES -- Saccharin -- Cyclamates -- Aspartame -- Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA) -- Vinyl Chloride -- Acrylonitrile -- Diethylstilbestrol (DES) -- ENVIRONMENTAL CONTAMINANTS -- Pesticides -- Polychlorinated Biphenyls (PCB's) -- Polybrominated Biphenyls (PBB's) -- Polycyclic Aromatic Hydrocarbons (PAH's) -- Benzo[a]pyrene -- Dibenz[a,h]anthracene -- Benz[a]anthracene -- OVERALL SUMMARY AND CONCLUSIONS -- Food Additives -- Environmental Contaminants -- REFERENCES -- 15 Inhibitors of Carcinogenesis -- EPIDEMIOLOGICAL STUDIES -- EXPERIMENTAL STUDIES -- Effects of Selected Chemicals -- Effects of Individual Foods on Carcinogen-Metabolizing Enzyme Systems -- Possible Adverse Effects of Inhibitors -- SUMMARY -- Epidemiological Studies -- Experimental Studies -- CONCLUSION -- REFERENCES -- SECTION C PATTERNS OF DIET AND CANCER -- 16 Cancer Incidence and Mortality -- GEOGRAPHICAL DIFFERENCES RELATED TO ETHNICITY -- CHANGES SUBSEQUENT TO MIGRATION -- CHANGING TIME TRENDS IN INCIDENCE AND MORTALITY -- INTERSITE CORRELATIONS OF INCIDENCE -- ASSOCIATIONS WITH SOCIOECONOMIC STATUS. 327 $aRELIGIOUS PRACTICES AND CANCER INCIDENCE AND MORTALITY -- CORRELATIONS OF INCIDENCE AND MORTALITY WITH DIETARY AND OTHER VARIABLES -- ASSOCIATIONS WITH OTHER DISEASES -- SUMMARY -- REFERENCES -- 17 The Relationship of Diet to Cancer at Specific Sites -- ESOPHAGEAL CANCER -- STOMACH CANCER -- COLON AND RECTAL CANCER -- LIVER CANCER -- PANCREATIC CANCER -- GALLBLADDER CANCER -- LUNG CANCER -- BLADDER CANCER -- RENAL CANCER -- BREAST CANCER -- ENDOMETRIAL CANCER -- OVARIAN CANCER -- PROSTATE CANCER -- REFERENCES -- 18 Assessment of Risk to Human Health -- INITIATORS OF CARCINOGENESIS -- MODIFIERS OF CARCINOGENESIS -- USE OF MUTAGENICITY TESTS -- USE OF EPIDEMIOLOGICAL STUDIES -- DIET-RELATED CARCINOGENESIS -- CONTRIBUTION OF DIET TO OVERALL RISK OF CANCER -- REFERENCES -- Glossary -- Appendix A Committee on Diet, Nutrition, and Cancer-Affiliations and Major Research Interests -- CHAIRMAN: -- VICE CHAIRMAN: -- MEMBERS: -- ADVISOR: -- NATIONAL RESEARCH COUNCIL STAFF: -- Index. 330 $aBased on a review of the scientific evidence, this book provides the assessment yet of the relationship between dietary and nutritional factors and the incidence of cancer. It presents dietary guidelines that are likely to reduce the risk of cancer as well as ensure good nutrition. 606 $aCancer$xNutritional aspects 606 $aFood habits 615 0$aCancer$xNutritional aspects. 615 0$aFood habits. 676 $a616.99/4071 712 02$aAssembly of Life Sciences (U.S.).$bCommittee on Diet, Nutrition, and Cancer. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828353303321 996 $aDiet, nutrition, and cancer$93962297 997 $aUNINA