LEADER 04616nam 2200745 a 450 001 9910828254803321 005 20240516065040.0 010 $a9786613694393 010 $a9781280784002 010 $a1280784008 010 $a9780470720691 010 $a0470720697 010 $a9780470718384 010 $a0470718382 035 $a(CKB)1000000000688140 035 $a(EBL)703908 035 $a(OCoLC)797918484 035 $a(SSID)ssj0000715483 035 $a(PQKBManifestationID)11400816 035 $a(PQKBTitleCode)TC0000715483 035 $a(PQKBWorkID)10706051 035 $a(PQKB)11381396 035 $a(MiAaPQ)EBC703908 035 $a(Au-PeEL)EBL703908 035 $a(CaPaEBR)ebr10575608 035 $a(CaONFJC)MIL369439 035 $a(Perlego)2771421 035 $a(EXLCZ)991000000000688140 100 $a19820514d1982 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMetabolic acidosis /$f[editors, Ruth Porter, Geralyn Lawrenson] 205 $a1st ed. 210 $aLondon $cPitman ;$aSummit, N.J. $cdistributed in North America by CIBA Pharmaceutical Co.$d1982 215 $a1 online resource (406 pages) 225 1 $aCiba Foundation symposium ;$v87 (new ser.) 300 $aSymposium on Metabolic Acidosis, held at the Ciba Foundation, London, 12-14 May 1981. 311 0 $a9780470663974 311 0 $a0470663979 311 0 $a9780272796511 311 0 $a0272796514 320 $aIncludes bibliographical references and indexes. 327 $aMetabolic acidosis; Contents; The hydrogen ion in normal metabolism; Discussion; The techniques and uses of intracellular pH measurements; Discussion; Energy metabolism and cellular pH in normal and pathological conditions. A new look through 31phosphorus nuclear magnetic resonance; Discussion; Acidosis and contractility of heart muscle; Discussion; Lactic acidosis in the brain: occurrence, triggering mechanisms and pathophysiological importance; Discussion; Glutamine metabolism in metabolic acidosis; Discussion; The regulation of ketogenesis; Discussion; General discussion I 327 $aFasting and ketone body metabolism Metabolic acidosis in exercise: (i) The fate of carboxylate ions during exercise; (ii) Clinical measurements of lactate loads; Preliminary observations on the metabolic responses to exercise in humans, using 31phosphorus nuclear magnetic resonance; Discussion; Metabolic acidosis and changes in water and electrolyte balance after maximal exercise; Some hormonal influences on glucose and ketone body metabolism in normal human subjects; Discussion; Effects of free fatty acids, insulin, glucagon and adrenaline on ketone body production in humans; Discussion 327 $aQuantitative aspects of L(+)-lactate metabolism in human beings Discussion; The role of catecholamines in metabolic acidosis; Discussion; Acid-base balance in diabetic ketoacidosis; Discussion; Isotope turnover studies in uncontrolled diabetes and the effects of insulin; Discussion; Metabolic acidosis in the critically ill; Discussion; The role of altered lactate kinetics in the pathogenesis of Type B lactic acidosis; Discussion; Organic acidurias: approach, results and clinical relevance; Discussion; Problems in the congenital lactic acidoses; Discussion; GENERAL DISCUSSION II 327 $aRegulation of energy metabolism, gluconeogenesis and ketogenesis The role of lactate in exercise; The relationship between intracellular and extracellular pH; Hormonal regulation of ketogenesis; Treatment of metabolic acidosis; Chairman's summary; Appendix; Index of contributors; Subject index 330 8 $aThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. 410 0$aCiba Foundation symposium ;$vnew ser. 87. 606 $aAcidosis$vCongresses 606 $aMetabolism$xDisorders$vCongresses 615 0$aAcidosis 615 0$aMetabolism$xDisorders 676 $a616.3/99 701 $aPorter$b Ruth$064811 701 $aCollins$b Geralyn M$0868426 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828254803321 996 $aMetabolic acidosis$92150525 997 $aUNINA