LEADER 04994nam 2200781 a 450 001 9910828254603321 005 20240516065100.0 010 $a9786613694416 010 $a9781280784026 010 $a1280784024 010 $a9780470720769 010 $a047072076X 010 $a9780470718469 010 $a0470718463 035 $a(CKB)1000000000688149 035 $a(EBL)703915 035 $a(OCoLC)797918499 035 $a(SSID)ssj0000715494 035 $a(PQKBManifestationID)11400817 035 $a(PQKBTitleCode)TC0000715494 035 $a(PQKBWorkID)10703767 035 $a(PQKB)10330227 035 $a(MiAaPQ)EBC703915 035 $a(Au-PeEL)EBL703915 035 $a(CaPaEBR)ebr10575609 035 $a(CaONFJC)MIL369441 035 $a(Perlego)2753489 035 $a(EXLCZ)991000000000688149 100 $a19830426d1983 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBrush border membranes 205 $a1st ed. 210 $aLondon $cPitman$dc1983 215 $a1 online resource (352 p.) 225 1 $aCiba Foundation symposium ;$vv. 95 300 $aEditors: Ruth Porter (Organizer) and Geralyn M. Collins. 300 $aProceedings of Symposium on: Brush border membranes held at the Ciba Foundation, London, 8-10 June 1982. 311 08$a9780470664131 311 08$a0470664134 311 08$a9780272796597 311 08$a027279659X 320 $aIncludes bibliographical references and indexes. 327 $aBrush border membranes; Contents; Chairman's introduction; Introductory remarks on the brush border; Microvillar endopeptidase, an enzyme with special topological features and a wide distribution; Discussion; Aminopeptidases and proteolipids of intestinal brush border; Discussion; Structure of microvillar enzymes in different phases of their life cycles; Discussion; Specific labelling of the hydrophobic domain of rat renal y-glutamyl transferase; Discussion; Biosynthesis and assembly of the largest and major intrinsic polypeptide of the small intestinal brush borders; Discussion 327 $aUse of monoclonal antibodies in the study of intestinal structure and function Discussion; Biosynthesis and transport of plasma membrane glyco- proteins in the rat intestinal epithelial cell: studies with sucrase- isomaltase; Discussion; GENERAL DISCUSSION I Biosynthesis and assembly of brush border proteins: (i) some co-translational models for protein insertion into membranes; molecular sizes of brush border enzymes during assembly; Distribution of enteropeptidase and aminopeptidase to non-brush border sites; General functions of the enterocyte 327 $aMolecular architecture of the microvillus cytoskeleton Discussion; Structure of human placental microvilli; Discussion; Regulation of cytoskeletal structure and contractility in the brush border; Discussion; Characterization of membrane glycoproteins involved in attachment of microfilaments to the microvillar membrane; Discussion; Structural and functional relationship between the membrane and the cytoskeleton in brush border microvilli; Discussion; GENERAL DISCUSSION II A pathological condition due to congenital disorganization of the brush border 327 $aConformational changes in the a-subunit, and cation transport by Na+, K+-ATPase Discussion; Properties of immunoglobulin G-Fc receptors from neonatal rat intestinal brush borders; Immunoglobulin G receptors of intestinal brush borders from neonatal rats; Discussion after the preceding two papers; Cotransport systems in the brush border membrane of the human placenta; Discussion; GENERAL DISCUSSION III Cytoskeleton and membrane-cytoskeleton interactions; The importance of structure for understanding the biosynthetic process; Future advances in study of brush border cytoskeleton 327 $aPhoto-affinity labeling to identify components of the neutral amino acid carrier in the intestinal microvillar membrane Chairman's closing remarks; Index to contributors; Subject index 330 8 $aThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. 410 0$aCiba Foundation symposium ;$vv. 95. 606 $aCell membranes$vCongresses 606 $aCell physiology$vCongresses 615 0$aCell membranes 615 0$aCell physiology 676 $a611.0181 676 $a611/.0181 701 $aPorter$b Ruth$064811 701 $aCollins$b Geralyn M$0868426 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828254603321 996 $aBrush border membranes$91991734 997 $aUNINA