LEADER 04239oam 2200649I 450 001 9910828038703321 005 20240404202154.0 010 $a1-317-83776-2 010 $a1-138-98775-1 010 $a1-315-82540-6 010 $a1-317-83777-0 024 7 $a10.4324/9781315825403 035 $a(CKB)2550000001313519 035 $a(EBL)1702106 035 $a(SSID)ssj0001223925 035 $a(PQKBManifestationID)12484160 035 $a(PQKBTitleCode)TC0001223925 035 $a(PQKBWorkID)11232892 035 $a(PQKB)11772643 035 $a(MiAaPQ)EBC1702106 035 $a(OCoLC)88224=7767 035 $a(EXLCZ)992550000001313519 100 $a20180706e19911991 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBehavioral and biochemical issues in substance abuse /$fFrank R. George, Doris Clouet, guest editors ; Barry Stimmel, editor 205 $a1st ed. 210 1$aNew York :$cRoutledge,$d1991. 215 $a1 online resource (260 p.) 300 $a"Has also been published as Journal of addictive diseases, volume 10, numbers 1/2, 1991"--T.p. verso. 311 $a1-56024-088-1 311 $a1-306-85521-7 320 $aIncludes bibliographical references at the end of each chapters. 327 $aCover; Half Title; Title Page; Copyright Page; Table of Contents; Editorial: Behavioral and Biochemical Genetic Issues in Substance Abuse; Genetic Selections for Nicotine and Cocaine Sensitivity in Mice; Where Are the mu Receptors That Mediate Opioid Analgesia? An Autoradiographic Study in the HAR and LAR Selection Lines; Behavioral and Neurochemical Studies in Diazepam-Sensitive and -Resistant Mice; Animal Models for the Study of Alcoholism: Utility of Selected Lines; Use of Recombinant Inbred Strains to Assess Vulnerability to Drug Abuse at the Genetic Level 327 $aThe Use of Recombinant Inbred Strains to Study Mechanisms of Drug ActionProgress Towards the Development of Animal Models of Smoking-Related Behaviors; Is There a Common Biological Basis for Reinforcement from Alcohol and Other Drugs?; Genetic Determinants of Susceptibility to the Rewarding and Other Behavioral Actions of Cocaine; Issues Surrounding the Assessment of the Genetic Determinants of Drugs as Reinforcing Stimuli; Establishment of Drug Discrimination and Drug Reinforcement in Different Animal Strains: Some Methodological Issues 327 $aBiochemical Genetic Differences in Vulnerability to Drug Effects: Is Statistically Significant Always Physiologically Important and Vice Versa?Genetic Influences in Human Substance Abuse; Methodological Issues in Genetic Studies of Human Substance Abuse; The Use of Nonneuronal Cells as an In Vitro Model System for Studying the Genetic Component of Cellular Response to Opiates and Other Drugs of Abuse; Selective Guide to Current ReferenceSources on Topics Discussed in ThisVolume; Behavioral and Biochemical Issues in Substance Abuse 330 $aThis excellent book is a concise yet thorough examination of the important and emerging field of the study of biological risk factors in drug abuse. Historically, drug abuse research has concentrated on the contributions of environmental and behavioral factors as the major influences on addiction. The revelatory studies in this volume examine the genetic contributions to drug taking behavior through the use of animal models, cellular experiments and human clinical studies. Behavioral and Biochemical Issues in Substance Abuse provides for the first time in one volume, up-to-date, easily digeste 606 $aSubstance abuse$xGenetic aspects$vCongresses 606 $aNeuropsychopharmacology$vCongresses 615 0$aSubstance abuse$xGenetic aspects 615 0$aNeuropsychopharmacology 676 $a616.86/042 676 $a616.86042 676 $a616.86042 701 $aClouet$b Doris H$01180841 701 $aGeorge$b Frank Richard$01642592 701 $aStimmel$b Barry$f1939-$0893301 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828038703321 996 $aBehavioral and biochemical issues in substance abuse$93987381 997 $aUNINA