LEADER 04117nam 22007454a 450 001 9910827527503321 005 20200520144314.0 010 $a9786610272327 010 $a9781280272325 010 $a1280272325 010 $a9780470869123 010 $a0470869127 010 $a9780470869116 010 $a0470869119 035 $a(CKB)1000000000244149 035 $a(EBL)470459 035 $a(OCoLC)57598366 035 $a(SSID)ssj0000218680 035 $a(PQKBManifestationID)11169174 035 $a(PQKBTitleCode)TC0000218680 035 $a(PQKBWorkID)10220613 035 $a(PQKB)10167377 035 $a(DNLM)101218548 035 $a(MiAaPQ)EBC470459 035 $a(Au-PeEL)EBL470459 035 $a(CaPaEBR)ebr10114005 035 $a(CaONFJC)MIL27232 035 $a(OCoLC)55588942 035 $a(FINmELB)ELB179127 035 $a(Perlego)2765637 035 $a(EXLCZ)991000000000244149 100 $a20040521d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPathological pain $efrom molecular to clinical aspects 205 $a1st ed. 210 $aChichester, UK ;$aHoboken, NJ, USA $cJohn Wiley$d2004 215 $a1 online resource (ix, 271 pages) $cillustrations 225 1 $aNovartis Foundation symposium ;$v261 300 $a"Symposium on Pathological pain: from molecular to clinical aspects, held at the Novartis Tsukuba Research Institute, Tsuskuba [sic], Japan, in collaboration with the Novartis Foundation (Japan) for the Promotion of Science, 30 September-2 October 2003; editors, Derek J. Chadwick (organizer) and Jamie Goode"--P. v. 311 0 $a9780470869109 311 0 $a0470869100 320 $aIncludes bibliographical references and indexes. 327 $aPATHOLOGICAL PAIN: FROM MOLECULAR TO CLINICAL ASPECTS; Contents; Participants; Chair's introduction; Regulation mechanisms of vanilloid receptors; Discussion; Sodium channels and neuropathic pain; Discussion; Ion channel activities implicated in pathological pain; Discussion; General discussion I; Chronic pain and microglia: the role of ATP; Discussion; Neurotrophic influences on neuropathic pain; Discussion; Changes in DRG neurons and spinal excitability in neuropathy; Discussion; Functional reorganization of the spinal pain pathways in developmental and pathological conditions; Discussion 327 $aCentral plasticity in pathological pain; Discussion; General discussion II; Anti-opioid systems in morphine tolerance and addiction - locus-specific involvement of nociceptin and the NMDA receptor; Discussion; Chronic morphine-induced plasticity among signalling molecules; Discussion; Opioid tolerance and neuroplasticity; Discussion; General discussion III; A mechanism-based understanding of bone cancer pain; Discussion; Mechanistic and clinical aspects of complex regional pain syndrome (CRPS); Discussion; Cortical pathophysiology of chronic pain; Discussion; Final discussion Translating basic research to the clinicIndex of contributors; Subject index 330 $aThis book brings together contributions from key investigators in the area of pathological pain. It covers the molecular basis of receptors and channels involved in nociception, the possible messages that cause neuropathic plasticity, spinal plasticity in neuropathy, plastic changes in opioid systems in neuropathy and opioid tolerance, and plastic changes related to pathological pain. 410 0$aNovartis Foundation symposium ;$v261. 606 $aPain$xMolecular aspects$vCongresses 606 $aPain$xPathophysiology$vCongresses 615 0$aPain$xMolecular aspects 615 0$aPain$xPathophysiology 676 $a616/.0472 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation (Japan) for the Promotion of Science. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910827527503321 996 $aPathological pain$94120130 997 $aUNINA