LEADER 05099nam 2200601 450 001 9910827316603321 005 20230615130032.0 010 $a0-12-801753-8 035 $a(CKB)3710000000464058 035 $a(EBL)2167902 035 $a(SSID)ssj0001596061 035 $a(PQKBManifestationID)16295881 035 $a(PQKBTitleCode)TC0001596061 035 $a(PQKBWorkID)14884683 035 $a(PQKB)10894198 035 $a(MiAaPQ)EBC2167902 035 $a(Au-PeEL)EBL2167902 035 $a(CaPaEBR)ebr11091595 035 $a(CaONFJC)MIL823998 035 $a(OCoLC)919002288 035 $a(PPN)198683782 035 $a(EXLCZ)993710000000464058 100 $a20150901h20152015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPrinciples of tumors $ea translational approach to foundations /$fLeon P. Bignold 210 1$aLondon :$cElsevier Science,$d[2015] 210 4$dİ2015 215 $a1 online resource (469 p.) 300 $aDescription based upon print version of record. 311 $a0-12-801565-9 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Principles of Tumors; Copyright Page; Contents; Preface and Acknowledgments; 1 Introduction; 1.1 Essential Aspects of the Nature, Types, and Rates of Incidence of Tumors; 1.1.1 "Tumors" Used in the Sense of "True" Tumors; 1.1.2 Classifications and Terminology of the Tumor Types; 1.1.3 Incidences Especially of Malignant Tumor Types; (a) General; (b) Influence of Ageing Populations; (c) Incidences of Tumor Types According to Kind of Parent Cell; (d) Use in Medical Practice; 1.1.4 Epidemiology of Tumors; 1.1.5 Uses of Animals in Research into the Aspects of Human Tumors 327 $a1.2 Basic Aspects of Etiopathogenesis1.2.1 Etiological Factors; 1.2.2 Pathogenesis: DNA Damage; 1.2.3 "Cancer Genes" in Pathogenesis; (a) When the Genomic Events Occur Entirely in the Somatic Cell (i.e., Without Germ-Line Genomic Alteration); (b) Requiring Germ-Line Alteration as Well as a Somatic Alteration in the Genome; (c) Cell Signaling in Normal Growth Control; 1.3 Abnormalities in Morphology and "Molecular Pathology"; 1.3.1 Background; 1.3.2 Grading of Tumors; (a) General; (b) Grading of Carcinomas of the Lung; (c) Grading of Carcinomas of the Breast 327 $a(d) Grading of Carcinomas of the Large Bowel (Colon and Rectum)(e) Grading of Carcinomas of the Prostate; 1.3.3 Staging of Cases of Tumor; (a) General; (b) Staging of Carcinoma of the Lung; (c) Staging of Carcinoma of the Breast; (d) Staging of Carcinoma of the Large Bowel (Colon and Rectum); (e) Staging of Carcinoma of the Prostate; 1.3.4 Importance of Micro-Metastases; 1.3.5 "Molecular Pathology" and Other Nonmorphological Features of Tumor Cells; 1.4 Fundamental Aspects of Clinical Features and Treatments; 1.4.1 Principles of Symptoms and Signs of Tumors; (a) Skin; (b) Respiratory Tract 327 $a(c) Female Breast(d) Alimentary System; (e) Hematopoietic and Lymphoid Systems; (f) Female Genital; (g) Male Genital; (h) Nervous System; (i) Urinary System; (j) Skeletal System; (k) Other Systems: Including Endocrine and Special Senses; (l) "Progression"; (m) Miscellaneous Clinical Features of Tumors; 1.4.2 Diagnosing Suspected Cases of Tumor; 1.4.3 Surgery; 1.4.4 General Aspects of Nonsurgical Treatments; 1.4.5 Radiation Therapies; 1.4.6 Anticancer Drug Therapies; 1.4.7 Relapses; 1.4.8 Common Side Effects of Nonsurgical Anticancer Therapies 327 $a1.4.9 "Lifetime Limits" of Doses of Certain Anticancer Therapies1.5 Prevention; References; 2 Theories and Definitions of Tumors; 2.1 Distinguishing Tumors from Other Swellings; 2.2 Early Definitions of Tumors Emphasized Uncontrolled Growth; 2.3 Theories Involving Disordered Biological Processes; 2.3.1 Degeneration; 2.3.2 Hypothetical Growth Processes: "Plasias" Including Neoplasia; 2.3.3 Deviations in Actual Biological and Nontumorous Pathological Processes; (a) Early Ideas of Embryonic Development-Related Phenomena; (b) Reduced Specialization; (c) Excessive Angiogenesis 327 $a(d) Abnormalities in Inflammatory Responses 330 $aPrinciples of Tumors covers all of the fundamental aspects of tumors, including their definitions, incidences, causation, pathogenesis, treatments, and prevention. The book provides a unique approach, integrating a wide range of basic bioscience findings with clinico-pathological observations and phenomena encountered in their treatment. As tumors are studied in fairly separate, broad areas, such as basic biological sciences, pathology, oncology, and epidemiology, this book brings together these perspectives, providing an all-inclusive text that benefits all researchers, while also providi 606 $aTumors 615 0$aTumors. 676 $a616.994 700 $aBignold$b Leon P.$f1947-$0903920 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910827316603321 996 $aPrinciples of tumors$93974087 997 $aUNINA