LEADER 05542nam 2200697 450 001 9910826916503321 005 20200520144314.0 010 $a1-5231-1066-X 010 $a1-118-89115-5 010 $a1-118-89109-0 010 $a1-118-89103-1 035 $a(CKB)3710000000117843 035 $a(EBL)1695070 035 $a(SSID)ssj0001222345 035 $a(PQKBManifestationID)11819373 035 $a(PQKBTitleCode)TC0001222345 035 $a(PQKBWorkID)11201193 035 $a(PQKB)10485089 035 $a(OCoLC)865452421 035 $a(MiAaPQ)EBC1695070 035 $a(DLC) 2013049613 035 $a(Au-PeEL)EBL1695070 035 $a(CaPaEBR)ebr10876083 035 $a(CaONFJC)MIL613408 035 $a(PPN)223933392 035 $a(EXLCZ)993710000000117843 100 $a20140615h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEndocrine disruptors in the environment /$fSushil K. Khetan 210 1$aHoboken, New Jersey :$cWiley,$d2014. 210 4$dİ2014 215 $a1 online resource (410 p.) 300 $aDescription based upon print version of record. 311 $a1-118-85293-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title Page; Contents; Foreword; Preface; Acronyms; Glossary; Chapter 1 Environmental Endocrine Disruptors; 1.1 Introduction; 1.1.1 The Endocrine System; 1.1.2 Endocrine Disrupting Chemicals (EDCs); 1.1.3 Sources of EDCs in the Environment; 1.1.4 Deleterious Effects of EDCs on Wildlife and on Humans; 1.1.5 Endocrine Disruption Endpoints; 1.2 Salient Aspects about Endocrine Disruption; 1.2.1 Low-Dose Effects and Nonmonotonic Dose Responses; 1.2.2 Exposures during Periods of Heightened Susceptibility in Critical Life Stages; 1.2.3 Delayed Dysfunction; 1.2.4 Importance of Mixtures 327 $a1.2.5 Transgenerational, Epigenetic Effects1.3 Historical Perspective of Endocrine Disruption; 1.4 Scope and Layout of this Book; 1.5 Conclusion; References; Part I Mechanisms of Hormonal Action and Putative Endocrine Disruptors; Chapter 2 Mechanisms of Endocrine System Function; 2.1 Introduction; 2.2 Hormonal Axes; 2.2.1 Hypothalamus-Pituitary-Gonad (HPG) Axis; 2.2.2 The Hypothalamic-Pituitary-Thyroid (HPT) Axis; 2.2.3 The Hypothalamic-Pituitary-Adrenal (HPA) Axis; 2.3 Hormonal Cell Signaling; 2.3.1 Receptors and Hormone Action; 2.3.2 Genomic Signaling Pathway 327 $a2.3.3 Rapid-Response Pathway (Nongenomic Signaling)2.3.4 Receptor Agonists, Partial Agonists, and Antagonists; 2.4 Sex Steroids; 2.4.1 Physiologic Estrogens; 2.4.2 Androgens; 2.5 Thyroid Hormones; 2.6 Conclusions and Future Prospects; References; Chapter 3 Environmental Chemicals Targeting Estrogen Signaling Pathways; 3.1 Introduction; 3.1.1 Gonadal Estrogen Function Disruptors; 3.2 Steroidal Estrogens; 3.2.1 Physiologic Estrogens; 3.2.2 17alpha-Ethinylestradiol (EE2); 3.2.3 Phytoestrogens; 3.2.4 Mycoestrogen-Zearalenone (ZEN); 3.3 Nonsteroidal Estrogenic Chemicals 327 $a3.3.1 Diethylstilbestrol (DES)3.3.2 Organochlorine Insecticides; 3.3.3 Polychlorinated Biphenyls (PCBs); 3.3.4 Alkyphenols; 3.3.5 Parabens (Hydroxy Benzoates); 3.3.6 Sun Screens (Chemical UV Filters); 3.4 Metalloestrogens; 3.4.1 Cadmium (Cd); 3.4.2 Lead (Pb); 3.4.3 Mercury (Hg); 3.4.4 Arsenic (As); 3.5 Conclusion and Future Prospects; References; Chapter 4 Anti-Androgenic Chemicals; 4.1 Introduction; 4.2 Testosterone Synthesis Inhibitors; 4.2.1 Phthalates; 4.3 Androgen Receptor (AR) Antagonists; 4.3.1 Organochlorine (OC) Pesticides; 4.3.2 Organophosphorus (OP) Insecticides 327 $a4.3.3 Bisphenol A (BPA)4.3.4 Polybrominated Diphenyl Ethers (PBDEs); 4.3.5 Vinclozolin (VZ); 4.3.6 Procymidone; 4.4 AR Antagonists and Fetal Testosterone Synthesis Inhibitors; 4.4.1 Prochloraz; 4.4.2 Linuron; 4.5 Comparative Anti-Androgenic Effects of Pesticides to Androgen Agonist DHT; 4.6 Conclusions and Future Prospects; References; Chapter 5 Thyroid-Disrupting Chemicals; 5.1 Introduction; 5.2 Thyroid Synthesis Inhibition by Interference in Iodide Uptake; 5.2.1 Perchlorate; 5.3 TH Transport Disruptors and Estrogen Sulfotransferases Inhibitors; 5.3.1 Polychlorinated Biphenyls (PCBs) 327 $a5.3.2 Triclosan 330 $aThe book is divided in three parts and 14 chapters. An introductory chapter provides an overview of endocrine system, and endocrine disruptors, discussing their salient features and presenting a historical perspective of endocrine disruption phenomena. The first part includes seven chapters that cover hormone-signalling mechanisms, followed by various broad classes of putative endocrine disruptors and an introduction to environmental epigenetic modifications. The second part in two chapters focuses on removal processes of various EDCs by biotic and abiotic transformation/ degradation. The 606 $aEndocrine disrupting chemicals$xEnvironmental aspects 606 $aEndocrine disrupting chemicals$xToxicity testing 606 $aEndocrine toxicology 615 0$aEndocrine disrupting chemicals$xEnvironmental aspects. 615 0$aEndocrine disrupting chemicals$xToxicity testing. 615 0$aEndocrine toxicology. 676 $a614.5/94 700 $aKhetan$b Sushil K.$01651814 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910826916503321 996 $aEndocrine disruptors in the environment$94002009 997 $aUNINA