LEADER 05785nam 2200745Ia 450 001 9910826824503321 005 20200520144314.0 010 $a0-470-96296-8 010 $a0-470-96293-3 010 $a0-470-96301-8 035 $a(CKB)3460000000080827 035 $a(EBL)818661 035 $a(OCoLC)829462283 035 $a(SSID)ssj0000622328 035 $a(PQKBManifestationID)12223758 035 $a(PQKBTitleCode)TC0000622328 035 $a(PQKBWorkID)10641712 035 $a(PQKB)10369330 035 $a(SSID)ssj0000597350 035 $a(PQKBManifestationID)11392938 035 $a(PQKBTitleCode)TC0000597350 035 $a(PQKBWorkID)10578103 035 $a(PQKB)11666126 035 $a(MiAaPQ)EBC818661 035 $a(Au-PeEL)EBL818661 035 $a(CaPaEBR)ebr10560510 035 $a(EXLCZ)993460000000080827 100 $a20110606d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSystems biology and livestock science /$fedited by Marinus F.W. te Pas, Henri Woelders, Andre Bannink 205 $a1st ed. 210 $aChichester, West Sussex ;$aAmes, Iowa $cWiley-Blackwell ;$aWageningen $cWageningen UR Livestock Research$d2011 215 $a1 online resource (756 p.) 300 $aDescription based upon print version of record. 311 $a0-8138-1174-0 320 $aIncludes bibliographical references and index. 327 $aCover; Title Page; Copyright; List of Contributors; Preface; From livestock production to biological science: from systems biology to livestock production; Chapter 1: Introduction to Systems Biology for Animal Scientists; Why Should Animal Scientists Be Interested in Learning About Systems Biology?; What Is Systems Biology?; A Systems Biology Paradigm: The Progress in Analysis of the Mammalian Immune Response Network; What Parts of Systems Biology Are in Use in Animal Science Today?; Further Reading; Partial Listing of Online Resources for Systems Biology; Web sites; Acknowledgments 327 $aChapter 2: Modeling Approaches in Systems Biology, Including Silicon Cell ModelsWhat Is Systems Biology; Various Systems Biological Models; Three Strategies to Build a Model: Top-Down, Middle-Out, and Bottom-Up; Perspectives of Silicon Cell Models: Advantages and Concerns; Use of Systems Biological Models, Including Silicon Cell Models; Acknowledgments; Chapter 3: The IUPS Physiome Project: A Worldwide Systems Biology Initiative; Introduction; Fundamental Principles of the Physiome Project; The Framework and Strategies of the Physiome Project; The Current Status of Physiome Modeling 327 $aConclusions and Future DirectionsAcknowledgments; Chapter 4: Systems Biology in Livestock Health and Disease; Introduction; Defining Systems Biology in the Medical Context; Establishing the Need for Systems Biology Approaches in Human and Veterinary Medicine; Systems Biology and Personalized Healthcare in Human Medicine; Areas of Application of Systems Biology to Human Medicine; Barriers to Implementing Personalized Medicine in Human Medical Practice; Systems Biology Techniques; Novel Technologies; Personalized Medicine Versus Livestock Population Health; Molecular Diagnostics 327 $aUsing Systems Biology to Understand Host-Pathogen InteractionsMolecular Epidemiology; Example of Systems Biology Applications in Livestock Health: Mastitis in Dairy Cattle; Conclusion: Challenges of Applying Systems Biology Concepts and Techniques to Livestock Health Management; Chapter 5: Systems Biology of Host-Food-Microbe Interactions in the Mammalian Gut; The Gastrointestinal Tract and Body Homeostasis; The Need for Systems Approaches to Study Diet-Host-Microbiota Interactions; The Gastrointestinal (GI) Tract; Energy Homeostasis; Signaling and Hormone Homeostasis 327 $aHomeostasis of Tolerance and ImmunityNutritional Challenges; The Intestinal Microbiota; Integrated Modeling Approaches; Challenges Ahead; Conclusions; Chapter 6: From Visual Biological Models Toward Mathematical Models of the Biology of Complex Traits; Introduction; Generation of a Biological Model; Association Studies Relating the Expression Levels of Genes or Proteins to Quantitative Traits; Bioinformatics Toward Systems Biology: Biological Models Toward Mathematical Models; Future Expectations; Acknowledgments 327 $aChapter 7: Molecular Networks as Sensors and Drivers of Uterine Receptivity in Livestock 330 $aSystems Biology is an interdisciplinary approach to the study of life made possible through the explosion of molecular data made available through the genome revolution and the simultaneous development of computational technologies that allow us to interpret these large data sets. Systems Biology has changed the way biological science views and studies life and has been implemented in research efforts across the biological sciences. Systems Biology and Livestock Science will be the first book to review the latest advances using this research methodology in efforts to improve the efficie 606 $aVeterinary physiology$xComputer simulation 606 $aLivestock 606 $aLivestock$xGenetics$xComputer simulation 615 0$aVeterinary physiology$xComputer simulation. 615 0$aLivestock. 615 0$aLivestock$xGenetics$xComputer simulation. 676 $a636.089/2 701 $aPas$b M. F. W. te$0286927 701 $aBannink$b Andre$01609233 701 $aWoelders$b Henri$01609234 712 02$aWageningen UR.$bLivestock Research. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910826824503321 996 $aSystems biology and livestock science$93936371 997 $aUNINA