LEADER 05576oam 2200553 450 001 9910826773703321 005 20190911112728.0 010 $a1-299-28136-2 010 $a981-4436-10-0 035 $a(OCoLC)831670001 035 $a(MiFhGG)GVRL8RAE 035 $a(EXLCZ)992560000000099544 100 $a20121228h20132013 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 10$aMethods in research and development of biomedical devices /$fKelvin K. L. Wong, School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Australia, Jiyuan Tu, School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Australia, Zhonghua Sun, Department of Imaging and Applied Physics, Curtin University, Australia, Don W. Dissanayake, School of Electrical and Electronic Engineering, University of Adelaide, Australia 210 $aSingapore ;$aHackensack, NJ $cWorld Scientific$dc2013 210 1$aNew Jersey :$cWorld Scientific,$d[2013] 210 4$d?2013 215 $a1 online resource (xvi, 177 pages) $cillustrations 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a981-4434-99-X 320 $aIncludes bibliographical references and index. 327 $aContents; Foreword; Preface; Acknowledgments; 1 Introduction; 1.1 Overview of Research and Development Processes; 1.2 Questions; 2 Overview of Biomedical Technologies; 2.1 Classification of Biomedical Devices; 2.2 Description of Biomedical Devices; 2.2.1 Aneurysmal Stents; 2.2.2 Endovascular Stents; 2.2.3 Biomedical MEMS Micropump; 2.2.4 Drug Delivery Devices; 2.3 Summary; 2.4 Questions; 3 Conceptualisation and Medical Image-Based Modelling; 3.1 CAD Modelling and Design Realisation; 3.1.1 Prosthetic Heart Valve; 3.1.2 Endovascular Stent Grafts; 3.1.3 Biomedical MEMS Micropump 327 $a3.2 Medical Imaging and Reconstruction3.2.1 Computed Tomography; 3.2.2 Virtual Intravascular Endoscopy; 3.2.3 CT Reconstruction of the Nasal Cavity, Pharynx and Larynx; 3.2.4 Magnetic Resonance Imaging; 3.3 Mechanical Prototyping; 3.3.1 Rapid Prototyping by Stereolithography; 3.3.2 Technical Limitations; 3.4 Summary; 3.5 Questions; 4 Medical Imaging and Visualisation; 4.1 Computed Tomography; 4.2 Virtual Intravascular Endoscopy; 4.2.1 Generation and Presentation of VIE; 4.2.2 Generation of VIE Images; 4.2.3 Threshold Range Along the Abdominal Aorta; 4.2.4 Optimal Threshold Selection 327 $a4.2.5 Generation of VIE Images with Aortic Stent and Artery Lumen Together4.2.6 Aortic Stent Wire Thicknesson VIE Images; 4.2.7 Image Display and Interpretation; 4.3 Optimal CT Scanning Protocols for VIE Visualisation; 4.4 Summary; 4.5 Questions; 5 Treatment of Aneurysms; 5.1 Introduction; 5.2 Open Surgery; 5.3 Minimally Invasive Techniques; 5.4 Medical Image Visualisation; 5.5 Technical Limitations; 5.6 Medical Imaging and Geometrical Reconstruction; 5.7 Conformance with Preliminary Concept; 5.8 Summary; 5.9 Questions; 6 Endovascular Stent Grafts; 6.1 Review of Device 327 $a6.1.1 What Is a Stent Graft?6.1.2 Why Endovascular Repair?; 6.2 Technical Developments; 6.2.1 Suprarenal Stent Grafts; 6.2.2 Fenestrated Stent Grafts; 6.3 Technical Success; 6.4 Long-term Outcomes; 6.5 Computational Modelling; 6.5.1 CFD of Suprarenal Stent Grafts; 6.5.1.1 Configuration of Stent Wires Crossing the Renal Artery Ostium; 6.5.1.2 Segmentation of CT Volume Data; 6.5.1.3 Generation of Aorta Mesh Models; 6.5.1.4 Simulation of Suprarenal Stent Wires Crossing the Renal Artery Ostium; 6.5.1.5 Computational Two-Way Fluid Solid Dynamics; 6.5.1.6 CFD Analysis 327 $a6.5.2 CFD of Fenestrated Stent Grafts6.5.2.1 Simulation o fFenestrated Renal Stents; 6.5.2.2 Numerical Verification; 6.5.2.3 Computational Two-Way Fluid Solid Dynamics and Analysis; 6.6 Summary; 6.7 Questions; 7 Nasal Drug Delivery; 7.1 Review of Device; 7.2 Computational Modelling; 7.2.1 Geometrical Meshing; 7.2.2 Physiological Boundary Conditions; 7.2.3 Simulating Flow in the Nasal Cavity; 7.3 Assessment of Modelling and Optimisation; 7.3.1 Insertion Angle; 7.3.2 Full Spray Cone Angle; 7.3.3 Implications for Nasal Drug Delivery; 7.4 Summary; 7.5 Questions; 8 Biomedical MEMS Micropump 327 $a8.1 Review of Device 330 $aThis book presents a road map for applying the stages in conceptualization, evaluation, and testing of biomedical devices in a systematic order of approach, leading to solutions for medical problems within a well-deserved safety limit. The issues discussed will pave the way for understanding the preliminary concepts used in modern biomedical device engineering, which include medical imaging, computational fluid dynamics, finite element analysis, particle image velocimetry, and rapid prototyping. This book would undoubtedly be of use to biomedical engineers, medical doctors, radiologists, and any other professionals related to the research and development of devices for health care. 606 $aMedical instruments and apparatus 606 $aBiomedical engineering 615 0$aMedical instruments and apparatus. 615 0$aBiomedical engineering. 676 $a610.28 700 $aWong$b Kelvin K. L.$0720729 702 $aTu$b Jiyuan 702 $aSun$b Zhonghua 702 $aDissanayake$b Don W. 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910826773703321 996 $aMethods in research and development of biomedical devices$93933567 997 $aUNINA