LEADER 04530nam 2200637Ia 450 001 9910826471703321 005 20240417001049.0 010 $a0-309-18368-5 010 $a1-280-18544-9 010 $a9786610185443 010 $a0-309-56958-3 010 $a0-585-32064-0 035 $a(CKB)110986584753104 035 $a(OCoLC)45843189 035 $a(CaPaEBR)ebrary10071320 035 $a(SSID)ssj0000202003 035 $a(PQKBManifestationID)11200186 035 $a(PQKBTitleCode)TC0000202003 035 $a(PQKBWorkID)10245955 035 $a(PQKB)10282384 035 $a(MiAaPQ)EBC3377297 035 $a(Au-PeEL)EBL3377297 035 $a(CaPaEBR)ebr10071320 035 $a(CaONFJC)MIL18544 035 $a(OCoLC)923269609 035 $a(EXLCZ)99110986584753104 100 $a20001013d2000 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMethyl bromide risk characterization in California /$fSubcommittee for the Review of the Risk Assessment of Methyl Bromide, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d2000 215 $a1 online resource (111 p.) 225 1 $aCompass series 300 $a"This project was supported by Agreement No. 98-0316 between the National Academy of Sciences and the California Department of Pesticide Regulation"--T.p. verso. 311 $a0-309-07087-2 320 $aIncludes bibliographical references (p. 76-83). 327 $aMETHYL BROMIDE RISK CHARACTERIZATION IN CALIFORNIA -- Copyright -- Preface -- Contents -- Executive Summary -- THE SUBCOMMITTEE'S TASK -- THE SUBCOMMITTEE'S EVALUATION -- Toxicology -- Recommendations -- Exposure -- Recommendations -- Risk Characterization -- Recommendations -- 1 Introduction -- BACKGROUND -- CALIFORNIA REGULATIONS -- THE SUBCOMMITTEE'S TASK -- ORGANIZATION OF THE REPORT -- 2 Toxicology and Hazard Identification -- PHARMACOKINETICS -- GENOTOXICITY -- ACUTE TOXICITY -- SUBCHRONIC TOXICITY -- CHRONIC INHALATION AND ONCOGENICITY -- REPRODUCTIVE TOXICITY -- DEVELOPMENTAL TOXICITY -- NEUROTOXICITY -- SELECTION OF CRITICAL EFFECTS FOR ACUTE TOXICITY -- 3 Exposure Assessment -- BACKGROUND -- LIKELY EXPOSURE SCENARIOS -- QUALITY OF DATA AVAILABLE FOR CHARACTERIZING EXPOSURES -- Analytical Methods -- Representativeness of Available Exposure Measurements -- Appropriateness of Normalizing Assumptions for Different Application Rates -- Appropriateness of Exposure-Duration Assumptions -- ACCURACY AND APPROPRIATENESS OF AVAILABLE MODELING TOOLS -- Exposure Estimates Based on Modeling -- Exposure of Residents in a Fumigated House -- Exposure of Residents Downwind from Soil Fumigations -- SUMMARY -- 4 Risk Characterization -- RISK CHARACTERIZATION GOALS -- HAZARD IDENTIFICATION -- Acute Toxicity Database -- Subchronic Toxicity Database -- Chronic Toxicity Database -- Developmental Neurotoxicity -- EXPOSURE ASSESSMENT -- Appropriateness of Acute-Exposure Definition -- Subchronic Exposure -- Chronic Exposure -- MARGIN-OF-EXPOSURE ANALYSIS -- Categories with More than Two Data Points -- Categories with One or Two Data Points -- UNCERTAINTY ISSUES -- Derivation of Reference Concentrations -- Sensitive Subpopulations -- Multiple Exposures -- SUMMARY -- 5 Conclusions and Recommendations -- TOXICOLOGICAL INFORMATION -- Conclusions -- Recommendations. 327 $aEXPOSURE ASSESSMENT -- Conclusions -- Recommendations -- RISK CHARACTERIZATION -- Conclusions -- Recommendations -- References -- Appendix A Biographical Information on the Subcommittee for the Review of the Risk Assessment of Methyl Bromide -- Appendix B Public Access Materials -- Appendix C Calculation of Air Exchange Rates -- ILLUSTRATIVE LOGNORMAL TREATMENT OF DATA FOR SELECTED OCCUPATIONAL EXPOSURES. 410 0$aCompass series (Washington, D.C.) 606 $aBromomethane$xToxicology$zCalifornia 606 $aHealth risk assessment$zCalifornia 615 0$aBromomethane$xToxicology 615 0$aHealth risk assessment 676 $a615.9/512 712 02$aNational Research Council (U.S.)$bSubcommittee for the Review of the Risk Assessment of Methyl Bromide. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910826471703321 996 $aMethyl bromide risk characterization in California$93946342 997 $aUNINA