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010   $a1-282-82246-2
010   $a9786612822469
010   $a0-470-66989-6
010   $a0-470-66980-2
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035   $a(EBL)624794
035   $a(OCoLC)680300617
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035   $a(PQKBTitleCode)TC0000430143
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100   $a20100630d2011      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aTumor microenvironment$b[electronic resource] /$fedited by Dietmar W. Siemann
205   $a2nd ed.
210   $aHoboken $cWiley-Blackwell$d2011
215   $a1 online resource (464 p.)
300   $aDescription based upon print version of record.
311   $a0-470-74996-2 
320   $aIncludes bibliographical references and index.
327   $aTumor Microenvironment; Contents; Preface; List of Contributors; 1 The Microenvironment in Cancer; 2 Establishing the Tumor Microenvironment; 3 Contributions of the Extracellular Matrix to Tumorigenesis; 4 Matrix Metalloproteinases and Their Inhibitors - Friend or Foe; 5 Role of Tumor-Associated Macrophages (TAM) in Cancer Related Inflammation; 6 Bone Marrow Stroma and the Leukemic Microenvironment; 7 Microenvironment Factors Influencing Skeletal Metastases; 8 Premetastatic Niches; 9 Hypoxia, Anerobic Metabolism, and Interstitial Hypertension; 10 Hypoxia and the DNA Damage Response
327   $a11 Non-Invasive Imaging of the Tumor Microenvironment12 Hypoxia-Inducible Factor 1 (HIF1) Mediated Adaptive Responses in the Solid Tumor; 13 Regulation of the Unfolded Protein Response in Cancer; 14 Influence of Hypoxia on Metastatic Spread; 15 Drug Penetration and Therapeutic Resistance; 16 Impact on Radiotherapy; 17 HIF-1 Inhibitors for Cancer Therapy; 18 Vascular-Targeted Molecular Therapy; Index
330   $aThe microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target 
606   $aCancer cells
606   $aCarcinogenesis
615  0$aCancer cells.
615  0$aCarcinogenesis.
676   $a616.99/4071
701   $aSiemann$b Dietmar W$01603413
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910826437803321
996   $aTumor microenvironment$93927778
997   $aUNINA