LEADER 04065nam 2200649Ia 450 001 9910826395803321 005 20230803020752.0 010 $a0-674-07473-4 010 $a0-674-07471-8 024 7 $a10.4159/harvard.9780674074712 035 $a(CKB)2550000001039572 035 $a(EBL)3301286 035 $a(SSID)ssj0000859958 035 $a(PQKBManifestationID)11436439 035 $a(PQKBTitleCode)TC0000859958 035 $a(PQKBWorkID)10896155 035 $a(PQKB)11284274 035 $a(MiAaPQ)EBC3301286 035 $a(DE-B1597)209780 035 $a(OCoLC)836870540 035 $a(OCoLC)956975918 035 $a(OCoLC)979953953 035 $a(DE-B1597)9780674074712 035 $a(Au-PeEL)EBL3301286 035 $a(CaPaEBR)ebr10682510 035 $a(EXLCZ)992550000001039572 100 $a20120828d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAdrenaline$b[electronic resource] /$fBrian B. Hoffman 210 $aCambridge, MA $cHarvard University Press$d2013 215 $a1 online resource (304 p.) 300 $aDescription based upon print version of record. 311 $a0-674-05088-6 320 $aIncludes bibliographical references and index. 327 $t Frontmatter -- $tContents -- $tPrologue -- $t1. The Goldilocks Principle -- $t2. Ruled by Glands -- $t3. A Country Doctor's Remarkable Discovery -- $t4. Finding a Needle in a Haystack -- $t5. Adrenaline Zips from Bench to Bedside -- $t6. Mind the Gap: Chemical Transmission from Sympathetic Nerves to Organs -- $t7. How Adrenaline Stimulates Cells -- $t8. Lock and Key: Receptors for Adrenaline -- $t9. New Drugs from Old Molecules -- $t10. Adrenaline Junkies -- $tAppendix: Adrenaline's Nobel Connections: An Extended Cast of Characters -- $tNotes -- $tGlossary -- $tFurther Reading -- $tAcknowledgments -- $tCredits -- $tIndex 330 $aInducing highs of excitement, anger, and terror, adrenaline fuels the extremes of human experience. A rush empowers superhuman feats in emergencies. Risk-taking junkies seek to replicate this feeling in dangerous recreations. And a surge may literally scare us to death. Adrenaline brings us up to speed on the fascinating molecule that drives some of our most potent experiences. Adrenaline was discovered in 1894 and quickly made its way out of the lab into clinics around the world. In this engrossing account, Brian Hoffman examines adrenaline in all its capacities, from a vital regulator of physiological functions to the subject of Nobel Prize-winning breakthroughs. Because its biochemical pathways are prototypical, adrenaline has had widespread application in hormone research leading to the development of powerful new drugs. Hoffman introduces the scientists to whom we owe our understanding, tracing the paths of their discoveries and aspirations and allowing us to appreciate the crucial role adrenaline has played in pushing modern medicine forward. Hoffman also investigates the vivid, at times lurid, place adrenaline occupies in the popular imagination, where accounts of its life-giving and lethal properties often leave the realm of fact. Famous as the catalyst of the "fight or flight" response, adrenaline has also received forensic attention as a perfect poison, untraceable in the bloodstream-and rumors persist of its power to revive the dead. True to the spirit of its topic, Adrenaline is a stimulating journey that reveals the truth behind adrenaline's scientific importance and enduring popular appeal. 606 $aAdrenaline$xHistory 606 $aHistory$y19th century 606 $aHistory$y20th century 606 $aHistory$y21st century 615 0$aAdrenaline$xHistory. 615 0$aHistory 615 0$aHistory 615 0$aHistory 676 $a616.4/5 700 $aHoffman$b Brian B$096326 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910826395803321 996 $aAdrenaline$94029666 997 $aUNINA